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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Other
Aluminum Chlorohydrate Anhydrous is a potent topical aluminum salt used as an antiperspirant. It belongs to the class of astringent drug products that temporarily block sweat ducts to manage hyperhidrosis.
Name
Aluminum Chlorohydrate Anhydrous
Raw Name
ALUMINUM CHLOROHYDRATE ANHYDROUS
Category
Other
Drug Count
14
Variant Count
14
Last Verified
February 17, 2026
About Aluminum Chlorohydrate Anhydrous
Aluminum Chlorohydrate Anhydrous is a potent topical aluminum salt used as an antiperspirant. It belongs to the class of astringent drug products that temporarily block sweat ducts to manage hyperhidrosis.
Detailed information about Aluminum Chlorohydrate Anhydrous
References used for this content
This page is for informational purposes only and does not replace medical advice. Consult a qualified healthcare professional before using any medication containing Aluminum Chlorohydrate Anhydrous.
Aluminum Chlorohydrate Anhydrous is a specialized, water-free (anhydrous) form of aluminum chlorohydrate, a group of specific aluminum salts that function as the primary active ingredients in over-the-counter (OTC) antiperspirant products. According to the FDA OTC Monograph for Antiperspirant Drug Products (21 CFR Part 350), this compound is classified as a topical astringent (a substance that shrinks or constricts body tissues). While many consumers associate aluminum salts strictly with cosmetic deodorants, Aluminum Chlorohydrate Anhydrous is pharmacologically distinct; it is an active drug ingredient designed to reduce the production of sweat (perspiration), whereas deodorants merely mask odor or target odor-causing bacteria.
Historically, the use of aluminum-based compounds for perspiration control dates back to the early 20th century, with the first patent for an aluminum-based antiperspirant granted in 1921. Aluminum Chlorohydrate Anhydrous represents a more refined, stable version of these early salts, optimized for modern delivery systems such as aerosols, roll-ons, and solid sticks. The 'anhydrous' designation is critical for formulation science, particularly in aerosol sprays where the presence of water could lead to corrosion of the container or instability of the propellant system.
In clinical practice, healthcare providers typically recommend Aluminum Chlorohydrate Anhydrous for the management of primary hyperhidrosis (excessive sweating not caused by another medical condition). It is one of the most widely used antiperspirant actives due to its balance of efficacy and a relatively low potential for skin irritation compared to more aggressive salts like aluminum chloride hexahydrate.
The mechanism of action for Aluminum Chlorohydrate Anhydrous is a physical-chemical process rather than a systemic biological interaction. When the product is applied to the skin surface, the aluminum salt dissolves in the sweat or moisture present on the skin and within the sweat duct. This dissolution triggers a chemical reaction where the aluminum ions undergo polymerization, forming a bulky, gelatinous hydroxide gel.
This gel complex migrates into the terminal portion of the eccrine sweat gland duct (the acrosyringium). As the pH of the sweat increases (moving from the acidic environment of the skin surface to the more neutral environment of the duct), the gel precipitates, forming a temporary 'plug.' This physical obstruction prevents the outward flow of sweat to the skin surface. Over time, as the skin naturally exfoliates (desquamation), these plugs are shed, which is why regular reapplication is necessary to maintain efficacy. It is important to note that this process does not 'stop' the body from producing sweat internally; rather, it redirects the fluid or allows it to be reabsorbed by the surrounding tissues.
Unlike oral or injectable medications, Aluminum Chlorohydrate Anhydrous is designed for minimal systemic absorption. Its pharmacokinetics are characterized by local action with very limited entry into the bloodstream.
Aluminum Chlorohydrate Anhydrous is primarily indicated for the following:
Aluminum Chlorohydrate Anhydrous is available in several topical delivery formats, usually ranging in concentration from 8% to 25%:
> Important: Only your healthcare provider can determine if Aluminum Chlorohydrate Anhydrous is right for your specific condition, especially if you have underlying kidney disease or chronic skin conditions.
For the treatment of excessive sweating, Aluminum Chlorohydrate Anhydrous is typically applied once daily.
Aluminum Chlorohydrate Anhydrous is generally considered safe for use in children and adolescents who have reached puberty and are experiencing increased body odor or perspiration.
Patients with severe renal impairment (typically defined as a GFR < 30 mL/min) must exercise caution. While systemic absorption is low, the kidneys are the primary route for aluminum excretion. The FDA requires a specific warning for these patients to consult a physician before use to prevent potential aluminum accumulation.
No dosage adjustments are required for patients with liver disease, as the drug is not metabolized by the liver.
Elderly patients may have thinner, more fragile skin (atrophy). Healthcare providers may recommend less frequent application or lower concentrations to avoid skin breakdown and irritation.
To maximize the efficacy of Aluminum Chlorohydrate Anhydrous and minimize side effects, follow these specific clinical guidelines:
If you miss an application, simply apply the next dose at your usual time. Do not apply a double amount to 'make up' for the missed dose, as this significantly increases the risk of skin irritation.
Systemic overdose from topical application is virtually impossible in individuals with normal kidney function. However, accidental ingestion can occur, particularly in children.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose or frequency without medical guidance, especially if you are using clinical-strength products.
Most side effects associated with Aluminum Chlorohydrate Anhydrous are localized to the site of application. These are typically mild and self-limiting:
> Warning: Stop using Aluminum Chlorohydrate Anhydrous and call your doctor immediately if you experience any of these serious reactions.
Prolonged use of Aluminum Chlorohydrate Anhydrous is generally considered safe for the general population. However, some patients may develop a 'tolerance' where the product seems less effective over several years, requiring a switch to a different aluminum salt or a higher concentration. There has been significant public debate regarding the long-term risk of breast cancer and Alzheimer's disease associated with aluminum antiperspirants.
According to the American Cancer Society (2023) and the Alzheimer's Association (2024), there is currently no consistent, peer-reviewed scientific evidence that links the use of aluminum-based antiperspirants to the development of breast cancer or Alzheimer's disease. The amount of aluminum absorbed through the skin is a tiny fraction of what is naturally absorbed from food and water.
No FDA black box warnings exist for Aluminum Chlorohydrate Anhydrous. However, the FDA mandates a specific warning for individuals with kidney disease due to the theoretical risk of aluminum accumulation when renal clearance is severely compromised.
Report any unusual symptoms or persistent skin changes to your healthcare provider to ensure continued safe use of the product.
Aluminum Chlorohydrate Anhydrous is for external use only. It should never be applied to mucous membranes (eyes, mouth, or genitals). If the product comes into contact with the eyes, rinse thoroughly with water for several minutes. Patients should be aware that while this medication is effective for sweat reduction, it does not treat the underlying cause of secondary hyperhidrosis (e.g., hyperthyroidism or infection), which requires a separate medical diagnosis.
There are no FDA black box warnings for Aluminum Chlorohydrate Anhydrous. It is classified as safe and effective for over-the-counter use when used according to label directions.
For the average healthy consumer, no specific lab tests or monitoring are required. However, for patients using high-concentration clinical-strength products under medical supervision:
There are no known effects of topical Aluminum Chlorohydrate Anhydrous on the ability to drive or operate heavy machinery. It does not cause drowsiness or impair motor skills.
There are no direct contraindications regarding alcohol consumption and the use of topical Aluminum Chlorohydrate Anhydrous. However, alcohol can cause vasodilation (widening of blood vessels) and increase sweating in some individuals, which may temporarily counteract the effectiveness of the antiperspirant.
There is no 'withdrawal' syndrome associated with stopping Aluminum Chlorohydrate Anhydrous. However, users should expect a return of original sweating levels within 48 to 72 hours after the last application as the aluminum plugs are naturally shed from the sweat ducts.
> Important: Discuss all your medical conditions, especially any history of kidney disease or chronic skin rashes, with your healthcare provider before starting a regimen with Aluminum Chlorohydrate Anhydrous.
There are no documented 'never-use' drug-drug interactions for topical Aluminum Chlorohydrate Anhydrous because systemic absorption is so minimal. However, it should not be used simultaneously with other topical medications on the same area of skin unless directed by a doctor.
There are no known food interactions (such as grapefruit or dairy) with topical Aluminum Chlorohydrate Anhydrous. Because the drug does not enter the digestive system or undergo hepatic metabolism, diet does not affect its efficacy or safety.
There are no documented interactions between Aluminum Chlorohydrate Anhydrous and herbal supplements like St. John's Wort or Ginkgo Biloba. Systemic supplements that increase sweating (such as certain thermogenic 'fat burners' containing high caffeine or ephedra-like compounds) may make the antiperspirant feel less effective.
Most interactions with Aluminum Chlorohydrate Anhydrous are pharmacodynamic and localized. They occur because two substances are applied to the same skin surface, leading to additive irritation or physical-chemical interference. There are no known pharmacokinetic interactions involving CYP450 induction or inhibition.
> Important: Tell your doctor about ALL medications, including topical creams, supplements, and herbal products you are taking, especially if you are undergoing diagnostic imaging like a mammogram.
Aluminum Chlorohydrate Anhydrous must NEVER be used in the following circumstances:
Conditions requiring a careful risk-benefit analysis by a healthcare provider include:
Patients who are allergic to one form of aluminum salt (e.g., Aluminum Zirconium Tetrachlorohydrex Gly) are highly likely to be cross-sensitive to Aluminum Chlorohydrate Anhydrous. If a reaction occurs with one brand of antiperspirant, it is vital to check the active ingredients of other brands, as most use related aluminum salts.
> Important: Your healthcare provider will evaluate your complete medical history, including kidney function and skin sensitivity, before recommending high-strength Aluminum Chlorohydrate Anhydrous.
Aluminum Chlorohydrate Anhydrous is generally considered safe for use during pregnancy.
There are no special considerations for patients with liver disease. Aluminum Chlorohydrate Anhydrous does not interact with liver enzymes or require hepatic clearance.
> Important: Special populations, particularly those with advanced kidney disease, require an individualized medical assessment before using aluminum-based products.
Aluminum Chlorohydrate Anhydrous functions as a topical astringent and antiperspirant. At the molecular level, the salt consists of complex polymers of aluminum, oxygen, and hydrogen. When applied to the skin, these polymers react with the water in sweat and the higher pH environment of the sweat duct. This causes the aluminum to precipitate into a metal-free hydroxide gel. This gel forms a physical 'plug' in the acrosyringium (the superficial part of the sweat duct). This blockage is temporary and does not damage the sweat gland itself; it merely prevents the secretion of fluid onto the skin surface.
| Parameter | Value |
|---|---|
| Bioavailability | < 0.02% (Topical) |
| Protein Binding | N/A (Negligible systemic levels) |
| Half-life | N/A (Primarily eliminated via skin shedding) |
| Tmax | N/A (Local action) |
| Metabolism | None (Not hepatically metabolized) |
| Excretion | Renal (for the < 0.02% absorbed) |
Aluminum Chlorohydrate Anhydrous belongs to the class of Topical Antiperspirants / Astringents. It is related to other aluminum salts such as Aluminum Zirconium Trichlorohydrex Gly and Aluminum Chloride Hexahydrate, though it is generally considered less irritating than the latter.
Medications containing this ingredient
Gillette Dryshield Cool Wave Dry
Secret Original Dry Powder Fresh
Sure Regular Antiperspirant And Deodorant
Old Spice Fresh High Endurance Dry
Secret Outlast Dry Protecting Powder
Old Spice Oasis With Vanilla Notes Dry
Gillette Dryshield Power Rush Dry
Secret Original Dry Shower Fresh
Sure Unscented Antiperspirant And Deodorant
Old Spice Pure Sport Scent Of Citrus Zest Dry
Secret Weightless Dry Brown Sugar Plus Argan Oil
Gillette Dryshield Arctic Ice Dry
+ 2 more drugs
Common questions about Aluminum Chlorohydrate Anhydrous
Aluminum Chlorohydrate Anhydrous is primarily used as the active ingredient in antiperspirants to reduce underarm wetness and manage excessive sweating (hyperhidrosis). It works by forming temporary physical plugs in the sweat ducts, preventing sweat from reaching the skin's surface. Unlike deodorants, which only mask odor, this compound actively reduces the volume of perspiration produced. It is commonly found in aerosol sprays, roll-ons, and solid sticks. Healthcare providers may also recommend it for off-label use on the hands or feet for patients with localized hyperhidrosis.
The most common side effects are localized skin reactions, including mild stinging, burning, or itching at the application site. These symptoms are most frequent if the product is applied to skin that is damp or recently shaved. Some users may also experience dry, flaky skin or mild redness (contact dermatitis) in the treated area. These effects are usually temporary and can be managed by ensuring the skin is completely dry before application. If severe irritation or a persistent rash develops, you should discontinue use and consult a healthcare provider.
There is no known direct interaction between alcohol consumption and the topical use of Aluminum Chlorohydrate Anhydrous. Because the medication is applied to the skin and has negligible systemic absorption, it does not interact with alcohol in the bloodstream or liver. However, alcohol is a known vasodilator that can increase body temperature and stimulate sweating in some people. This might make your antiperspirant feel less effective, but it does not pose a safety risk. Always follow the application instructions regardless of alcohol intake.
Yes, Aluminum Chlorohydrate Anhydrous is generally considered safe for use during pregnancy. Clinical studies show that less than 0.02% of the aluminum applied to the skin is absorbed into the bloodstream, which is a negligible amount compared to aluminum found naturally in the diet. There is no evidence suggesting that topical aluminum salts cause birth defects or other pregnancy complications. Most obstetricians allow the continued use of standard OTC antiperspirants. However, if you have concerns, it is always best to discuss them with your healthcare provider during a prenatal visit.
While you may notice a slight reduction in sweat after the first application, it typically takes 3 to 7 days of consistent daily use to reach maximum effectiveness. This is because the 'plugs' in the sweat ducts need time to build up and stabilize. For the best results, clinical experts recommend applying the product at night before bed, when sweat glands are least active. This allows the aluminum salt to penetrate deeper into the duct. Once the desired level of sweat control is achieved, some users find they can maintain results by applying the product every other day.
Yes, you can stop using Aluminum Chlorohydrate Anhydrous at any time without experiencing withdrawal symptoms or 'rebound' sweating. However, because the effect of the medication relies on physical plugs that are naturally shed during skin exfoliation, your sweating will return to its original levels within a few days of stopping. There are no long-term changes to your sweat glands caused by the medication. If you were using it for a medical condition like hyperhidrosis, your symptoms will likely reappear shortly after discontinuation. Talk to your doctor about alternative treatments if you decide to stop.
If you miss an application of Aluminum Chlorohydrate Anhydrous, simply apply it the following evening or at your next scheduled time. Do not apply extra product or 'double up' to compensate for the missed dose, as this will not increase efficacy and may significantly increase the risk of skin irritation. Consistency is key for maintaining the sweat-duct plugs, so a single missed dose might result in a slight increase in wetness the next day. Simply resume your normal routine as soon as you remember. If you miss several days, you may need to restart the 'loading' phase of daily applications.
No, Aluminum Chlorohydrate Anhydrous does not cause weight gain. It is a topical medication with almost no systemic absorption, meaning it does not affect your metabolism, hormones, or appetite. There is no biological mechanism by which an antiperspirant could influence body weight. Any changes in weight you experience while using this product are likely due to other factors such as diet, exercise, or underlying medical conditions. If you are concerned about unexplained weight changes, you should consult your healthcare provider for a thorough evaluation.
Aluminum Chlorohydrate Anhydrous can generally be used safely alongside most oral medications because it does not enter the bloodstream in significant amounts. However, you should be cautious when using other topical products on the same area of skin. For example, using medicated acne creams or retinoids in the underarm area while using a strong antiperspirant can lead to severe skin irritation. Additionally, you must not wear aluminum-containing products during a mammogram, as the aluminum particles can interfere with the X-ray results. Always inform your doctor about all products you are applying to your skin.
Aluminum Chlorohydrate Anhydrous is the active ingredient in many different brands of antiperspirants, including both 'name brand' and 'store brand' (generic) versions. In the United States, these products are regulated by the FDA's OTC monograph system, which ensures that generic versions containing the same concentration of the active ingredient are as effective as the brand-name equivalents. When shopping, you can check the 'Drug Facts' label on the back of the package to confirm that Aluminum Chlorohydrate is the active ingredient. Generic versions are typically more cost-effective while providing the same level of sweat protection.