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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Other
Aluminum Sesquichlorohydrate is a topical aluminum salt used primarily as an antiperspirant to control excessive sweating (hyperhidrosis). It belongs to the class of aluminum-based sweat-reducing agents and is commonly found in clinical-strength over-the-counter formulations.
Name
Aluminum Sesquichlorohydrate
Raw Name
ALUMINUM SESQUICHLOROHYDRATE
Category
Other
Drug Count
378
Variant Count
445
Last Verified
February 17, 2026
About Aluminum Sesquichlorohydrate
Aluminum Sesquichlorohydrate is a topical aluminum salt used primarily as an antiperspirant to control excessive sweating (hyperhidrosis). It belongs to the class of aluminum-based sweat-reducing agents and is commonly found in clinical-strength over-the-counter formulations.
Detailed information about Aluminum Sesquichlorohydrate
This page is for informational purposes only and does not replace medical advice. Consult a qualified healthcare professional before using any medication containing Aluminum Sesquichlorohydrate.
Aluminum Sesquichlorohydrate is a specific group of aluminum salts that function as the active ingredient in many over-the-counter (OTC) and clinical-strength antiperspirants. It is chemically characterized by a higher aluminum-to-chloride ratio than standard aluminum chlorohydrate, which often allows for better efficacy in moisture control with a potentially lower risk of skin irritation. This compound belongs to the class of drugs known as topical antiperspirants.
According to the FDA Over-the-Counter Monograph (21 CFR 350), Aluminum Sesquichlorohydrate is recognized as safe and effective for reducing underarm perspiration. Unlike deodorants, which merely mask odor or target bacteria, Aluminum Sesquichlorohydrate physically alters the sweat production process. While it has been used in various formulations for decades, its primary role remains the management of hyperhidrosis (excessive sweating) and daily moisture control.
At the molecular level, Aluminum Sesquichlorohydrate works through a physical rather than a systemic biochemical mechanism. When applied to the skin surface, the aluminum salts dissolve in the sweat or moisture present in the sweat duct. This creates a chemical reaction that forms a shallow, temporary "plug" or gel-like precipitate within the eccrine sweat gland duct (the tube through which sweat travels to the skin surface).
These plugs significantly reduce the flow of sweat to the surface of the skin. Over time, these plugs are naturally shed through the skin's normal exfoliation process, which is why regular application is required to maintain efficacy. By reducing the amount of moisture on the skin, the compound also indirectly limits the growth of odor-causing bacteria that thrive in damp environments.
Aluminum Sesquichlorohydrate is FDA-approved for the following indications:
Aluminum Sesquichlorohydrate is available in several topical delivery systems, including:
> Important: Only your healthcare provider can determine if Aluminum Sesquichlorohydrate is right for your specific condition, especially if you have underlying skin disorders or kidney disease.
For the treatment of perspiration, Aluminum Sesquichlorohydrate is typically used in concentrations ranging from 10% to 25% in over-the-counter products.
Aluminum Sesquichlorohydrate is generally considered safe for use in adolescents who have reached puberty. However, its use in younger children should be directed by a pediatrician. There is no standard age-based dosing for children under 12, as excessive sweating in young children may indicate an underlying medical condition that requires professional diagnosis.
Patients with severe renal impairment (kidney disease) should consult a doctor before use. While absorption is minimal, the kidneys are responsible for clearing absorbed aluminum, and individuals with a GFR (Glomerular Filtration Rate) less than 30 mL/min may be at a theoretical risk of accumulation.
No dosage adjustments are required for patients with liver disease, as the drug is not metabolized by the liver.
No specific dosage adjustments are necessary for elderly patients, though they should be monitored for skin sensitivity or thinning skin which may increase irritation risk.
If you miss an application, simply apply the next dose at your usual time. Do not apply double the amount to make up for a missed dose.
Systemic overdose from topical application is virtually impossible. However, accidental ingestion can occur, especially in children. Signs of ingestion may include gastrointestinal upset or nausea. In case of ingestion, contact a Poison Control Center immediately.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose or frequency of use without medical guidance.
> Warning: Stop using Aluminum Sesquichlorohydrate and call your doctor immediately if you experience any of these symptoms:
There is no high-quality clinical evidence suggesting that long-term use of Aluminum Sesquichlorohydrate leads to systemic diseases such as Alzheimer's or breast cancer. The primary long-term effect is localized skin sensitization or chronic dryness in sensitive individuals. Most major health organizations, including the American Cancer Society, state that there is no clear link between aluminum-based antiperspirants and cancer.
No FDA black box warnings exist for Aluminum Sesquichlorohydrate. It is generally recognized as safe for over-the-counter use when used according to label directions.
Report any unusual symptoms or persistent skin changes to your healthcare provider.
Aluminum Sesquichlorohydrate is for external use only. It should never be applied to the eyes, mouth, or mucous membranes. If the product comes into contact with the eyes, rinse thoroughly with cool water for several minutes.
No FDA black box warnings for Aluminum Sesquichlorohydrate.
Routine lab tests are not required for healthy individuals using topical Aluminum Sesquichlorohydrate. However, patients with stage 4 or 5 chronic kidney disease may require periodic monitoring of serum aluminum levels if they are using high-potency aluminum products over large surface areas.
There are no known effects of Aluminum Sesquichlorohydrate on the ability to drive or operate heavy machinery.
There are no direct contraindications between alcohol consumption and the use of topical Aluminum Sesquichlorohydrate. However, alcohol can cause vasodilation (widening of blood vessels), which may increase sweating and potentially reduce the effectiveness of the antiperspirant.
There is no withdrawal syndrome associated with Aluminum Sesquichlorohydrate. Upon discontinuation, sweat production will typically return to its baseline level within 3 to 7 days as the ductal plugs are naturally shed.
> Important: Discuss all your medical conditions, especially any history of kidney problems or skin allergies, with your healthcare provider before starting Aluminum Sesquichlorohydrate.
There are no known systemic drugs that are strictly contraindicated with the topical use of Aluminum Sesquichlorohydrate. However, it should not be used simultaneously with other potent topical medications on the same area of skin unless directed by a doctor.
There are no known food interactions with topical Aluminum Sesquichlorohydrate. Dietary aluminum intake (from cookware or certain foods) is processed differently and does not typically interact with topical application.
There are no documented interactions between Aluminum Sesquichlorohydrate and common herbal supplements like St. John's Wort or Ginkgo Biloba due to the lack of systemic absorption.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, even if they are topical.
Patients who react to one type of aluminum salt are likely to react to others in the same class. If you have had a rash or reaction to "standard" antiperspirants, you should use Aluminum Sesquichlorohydrate with caution.
> Important: Your healthcare provider will evaluate your complete medical history and skin type before recommending the use of high-concentration Aluminum Sesquichlorohydrate.
FDA Pregnancy Category: Not Assigned. Topical Aluminum Sesquichlorohydrate is generally considered safe during pregnancy because systemic absorption is negligible. There is no evidence suggesting that topical aluminum use leads to birth defects or pregnancy complications. However, as with all products, pregnant individuals should consult their obstetrician before starting new treatments.
Aluminum Sesquichlorohydrate is not expected to pass into breast milk in any significant quantity due to its low systemic absorption. It is considered compatible with breastfeeding. Care should be taken to ensure the infant does not come into direct contact with the treated skin area to avoid accidental ingestion or skin irritation for the baby.
Approved for use in adolescents. It is not recommended for infants or young children unless specifically directed by a physician, as their skin is thinner and more prone to absorption and irritation.
Older adults may use this product safely. However, because skin becomes thinner and drier with age, geriatric patients should monitor for increased irritation or the development of contact dermatitis.
As noted by the FDA, patients with a GFR < 30 mL/min should exercise extreme caution. While the risk is low, the inability to clear even trace amounts of absorbed aluminum is a clinical concern in this population.
No adjustments or special precautions are required for patients with liver impairment.
> Important: Special populations require individualized medical assessment to ensure the benefits of sweat control outweigh any potential localized or systemic risks.
Aluminum Sesquichlorohydrate acts as an astringent and antiperspirant. When applied, the salts diffuse into the terminal portion of the sweat ducts. The higher pH environment within the duct causes the aluminum complex to polymerize and form a physical mucopolysaccharide plug. This plug mechanically obstructs the eccrine sweat gland, preventing the secretion of sweat onto the skin surface.
| Parameter | Value |
|---|---|
| Bioavailability | <0.01% (Topical) |
| Protein Binding | N/A (Negligible systemic levels) |
| Half-life | N/A (Acts locally) |
| Tmax | N/A (Local action only) |
| Metabolism | None (Exfoliated from skin) |
| Excretion | Renal (trace amounts absorbed) |
Aluminum Sesquichlorohydrate is classified as a Topical Antiperspirant. It is closely related to Aluminum Chlorohydrate and Aluminum Zirconium Tetrachlorohydrex GLY.
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Common questions about Aluminum Sesquichlorohydrate
Aluminum Sesquichlorohydrate is primarily used as an active ingredient in antiperspirants to reduce underarm wetness and control excessive sweating. It works by creating temporary plugs in the sweat ducts, which physically prevents sweat from reaching the skin's surface. This is particularly helpful for individuals with hyperhidrosis or those who find standard deodorants insufficient for moisture control. It is often found in 'clinical strength' over-the-counter products because of its effective balance between sweat reduction and skin compatibility. Talk to your doctor if you have concerns about excessive sweating.
The most frequently reported side effects are localized to the area of application and include skin itching, redness, and a mild stinging sensation. These symptoms are often temporary and occur most commonly if the product is applied to skin that is slightly damp or recently shaved. Some users may also experience localized dryness or skin flaking with daily use. If you develop a persistent rash or severe burning, you should discontinue use and consult a healthcare provider. Most minor irritations can be managed by ensuring the skin is completely dry before application.
There is no known direct interaction between alcohol consumption and the topical use of Aluminum Sesquichlorohydrate. Because the drug is applied to the skin and has negligible systemic absorption, it does not interact with alcohol in the liver or bloodstream. However, alcohol can increase body temperature and cause blood vessels to dilate, which might lead to increased sweating and potentially wash away the product before it can form effective plugs. For the best results, apply the product to dry skin at night regardless of alcohol intake. Always consume alcohol in moderation as part of a healthy lifestyle.
Aluminum Sesquichlorohydrate is generally considered safe for use during pregnancy because it is applied topically and very little of the ingredient enters the bloodstream. Major medical consensus suggests that the trace amounts of aluminum that could be absorbed do not pose a risk to a developing fetus. There are no known links between topical antiperspirant use and birth defects or other pregnancy complications. However, because every pregnancy is unique, it is always best to confirm the safety of any over-the-counter product with your obstetrician or healthcare provider. Maintaining comfort and hygiene is important during pregnancy.
While you may notice some reduction in sweat within a few hours of the first application, Aluminum Sesquichlorohydrate typically takes 2 to 3 days of consistent nightly use to reach its full effectiveness. This time allows the aluminum salts to build up sufficient plugs within the sweat ducts to significantly block moisture flow. Many clinical-strength products recommend an initial 'startup' phase of nightly application followed by a maintenance phase of 1-2 times per week. The duration of effect usually lasts between 24 and 48 hours after the last application. If you do not see improvement after a week, consult a professional.
Yes, you can stop using Aluminum Sesquichlorohydrate at any time without experiencing withdrawal symptoms or physical side effects. Because the product works through a physical mechanism on the skin's surface, stopping use simply means the sweat duct plugs will naturally wash away or be shed with dead skin cells. You can expect your normal sweating patterns to return within 3 to 7 days after your last application. There is no need to taper off the product or reduce use gradually. If you were using it for a medical condition like hyperhidrosis, your symptoms will likely return to their previous level.
If you miss a dose of Aluminum Sesquichlorohydrate, there is no cause for concern; simply apply it at your next scheduled time, usually the following evening. Do not apply extra product or 'double up' to compensate for the missed dose, as this will not increase effectiveness and may increase the risk of skin irritation. Consistency is key for managing excessive sweat, but a single missed application will likely not result in an immediate return of heavy sweating. Just resume your normal routine as soon as you remember. If you find you are missing doses frequently, try setting a reminder.
No, Aluminum Sesquichlorohydrate does not cause weight gain. It is a topical agent that acts locally on the sweat glands of the skin and does not enter the systemic circulation in amounts large enough to affect metabolism, hormones, or fat storage. There is no clinical evidence linking the use of antiperspirants to changes in body weight or composition. If you experience unexplained weight gain while using this or any other product, it is likely due to other factors such as diet, activity level, or an underlying medical condition. Consult your doctor to investigate any sudden changes in weight.
Aluminum Sesquichlorohydrate is generally safe to use alongside oral medications because it is not absorbed into the bloodstream in significant amounts. However, you should be cautious when using other topical products, such as medicated creams or retinoids, on the same area of skin, as this can increase the risk of irritation. It is also important to avoid using it on the day of a mammogram, as aluminum particles can sometimes interfere with imaging results. Always inform your healthcare provider about all the products you use, including topical ones. This ensures that your entire treatment regimen is safe and effective.
Yes, Aluminum Sesquichlorohydrate is available in many generic and store-brand antiperspirant formulations. Because it is an over-the-counter active ingredient regulated by the FDA's monograph system, the generic versions are required to meet the same standards for safety and efficacy as brand-name 'clinical strength' products. You can often find it by checking the 'Active Ingredients' list on the back of the packaging. Generic versions are typically more cost-effective while providing the same level of sweat protection. If you have a specific skin sensitivity, you may want to compare the inactive ingredients between brands.