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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Non-Standardized Plant Allergenic Extract [EPC]
Chelidonium Majus is a plant-derived extract primarily classified as a Non-Standardized Plant Allergenic Extract. It is utilized in clinical settings for diagnostic allergy testing and specific immunotherapy, though it contains various alkaloids that impact metabolic and adrenergic pathways.
Name
Chelidonium Majus
Raw Name
CHELIDONIUM MAJUS
Category
Non-Standardized Plant Allergenic Extract [EPC]
Drug Count
156
Variant Count
217
Last Verified
February 17, 2026
About Chelidonium Majus
Chelidonium Majus is a plant-derived extract primarily classified as a Non-Standardized Plant Allergenic Extract. It is utilized in clinical settings for diagnostic allergy testing and specific immunotherapy, though it contains various alkaloids that impact metabolic and adrenergic pathways.
Detailed information about Chelidonium Majus
This page is for informational purposes only and does not replace medical advice. Consult a qualified healthcare professional before using any medication containing Chelidonium Majus.
Chelidonium Majus, commonly known as Greater Celandine, is a perennial herbaceous plant belonging to the poppy family (Papaveraceae). In a clinical and pharmacological context, it is classified primarily as a Non-Standardized Plant Allergenic Extract [EPC]. While it is often recognized in botanical medicine for its alkaloid content, its primary pharmaceutical application involves its use as an allergen for diagnostic testing and immunotherapy.
According to the FDA’s Electronic Product Code (EPC) classification, Chelidonium Majus is grouped among various allergenic extracts, including fungal, food, and insect venom extracts. It is important to note that while it is classified as an allergenic extract, the raw plant contains isoquinoline alkaloids such as chelidonine, coptisine, and sanguinarine, which contribute to its complex pharmacological profile. Historically, extracts of this plant have been used in traditional medicine, but modern clinical use is strictly regulated due to potential toxicity.
The mechanism of action for Chelidonium Majus is multifaceted. As an allergenic extract, it works by inducing a controlled immune response. When used in skin prick testing, it triggers the release of histamine from mast cells in sensitized individuals, allowing clinicians to identify specific plant allergies.
At a molecular level, the components of Chelidonium Majus exhibit Ammonium Ion Binding Activity [MoA] and interact with adrenergic systems. Specifically, research suggests it may act as an Adrenergic alpha-Agonist and Adrenergic beta-Agonist, influencing smooth muscle contraction and heart rate. Furthermore, its alkaloids have shown Calcium Chelating Activity, which may modulate intracellular signaling pathways.
Chelidonium Majus is primarily indicated for:
> Important: Only your healthcare provider can determine if Chelidonium Majus is right for your specific condition.
Dosage for Chelidonium Majus varies significantly based on its intended use as a diagnostic tool or a therapeutic agent.
Chelidonium Majus extracts are generally not recommended for use in infants. In older children, pediatric dosing for immunotherapy must be strictly supervised by a pediatric allergist and is usually calculated based on the child's sensitivity levels rather than weight.
No specific dosage adjustments are provided for renal impairment when used as a topical allergen; however, systemic use requires caution due to potential accumulation of alkaloids.
Extreme Caution: Chelidonium Majus has been associated with hepatotoxicity (liver damage). Patients with pre-existing liver disease should generally avoid systemic exposure to this substance.
Elderly patients may have increased sensitivity to the adrenergic effects of the alkaloids. Lower starting doses in immunotherapy are often recommended.
Chelidonium Majus allergenic extracts are almost exclusively administered by healthcare professionals in a clinical setting. If using a prescribed oral preparation (where legal), it should be taken exactly as directed, usually away from meals to avoid interference with absorption.
In the context of immunotherapy, a missed dose can increase the risk of an allergic reaction during the next administration. Contact your allergist immediately to reschedule; do not double the dose.
Signs of systemic overdose (especially if ingested) include nausea, severe abdominal pain, dizziness, and jaundice (yellowing of the skin). In the event of an accidental ingestion or an injection reaction, seek emergency medical services immediately.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance.
> Warning: Stop taking Chelidonium Majus and call your doctor immediately if you experience any of these.
Prolonged systemic use of Chelidonium Majus may lead to chronic liver enzyme elevations. Regular monitoring is required for any patient on long-term therapy involving this extract.
No FDA black box warnings are currently issued for Chelidonium Majus as a non-standardized allergenic extract. However, European regulatory agencies have issued warnings regarding its hepatotoxic potential in oral supplements.
Report any unusual symptoms to your healthcare provider.
Chelidonium Majus contains biologically active alkaloids that can have significant systemic effects. It should only be used under the direct supervision of a qualified medical professional, particularly when used for immunotherapy.
No FDA black box warnings for Chelidonium Majus.
Chelidonium Majus generally does not interfere with the ability to drive; however, if a systemic allergic reaction or dizziness occurs, patients should avoid these activities.
Alcohol should be avoided or strictly limited, as it can exacerbate the hepatotoxic risks associated with the alkaloids found in Chelidonium Majus.
If liver enzymes become elevated (typically 3x the upper limit of normal), the substance must be discontinued immediately.
> Important: Discuss all your medical conditions with your healthcare provider before starting Chelidonium Majus.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking.
Patients allergic to other members of the Papaveraceae family (such as poppies) may exhibit cross-reactivity to Chelidonium Majus.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Chelidonium Majus.
Chelidonium Majus is generally categorized as Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Use during pregnancy is typically avoided unless the diagnostic benefit clearly outweighs the risk of anaphylaxis, which could cause fetal hypoxia.
It is unknown if the alkaloids or allergenic components are excreted in human milk. Caution should be exercised, and breastfeeding mothers should consult their physician regarding the potential for infant exposure to hepatotoxic alkaloids.
Safety and effectiveness in children under the age of 5 have not been established for immunotherapy. Diagnostic testing should be performed with caution by a specialist.
Clinical studies have not identified significant differences in responses between the elderly and younger patients; however, the higher prevalence of cardiovascular disease in this population increases the risk associated with adrenergic agonist activity.
No specific dose adjustments are required for diagnostic testing. For systemic use, monitoring is advised as renal clearance of metabolites may be reduced.
Contraindicated in severe hepatic impairment (Child-Pugh Class C). In mild to moderate cases, extreme caution and frequent LFT monitoring are required.
> Important: Special populations require individualized medical assessment.
Chelidonium Majus acts as a Non-Standardized Plant Allergenic Extract. Its primary clinical effect is the induction of IgE-mediated mast cell degranulation for diagnostic purposes. On a molecular level, its alkaloids (e.g., chelidonine) act as Ammonium Ion Binding Agents and exhibit Adrenergic alpha and beta-Agonist properties. It also possesses Calcium Chelating Activity, which interferes with various enzymatic processes.
| Parameter | Value |
|---|---|
| Bioavailability | Low (Topical/SC); Variable (Oral) |
| Protein Binding | Not fully characterized |
| Half-life | 2–6 hours (alkaloid components) |
| Tmax | 1.5 hours (oral) |
| Metabolism | Hepatic (CYP450 pathways) |
| Excretion | Renal (approx. 60%), Fecal (approx. 40%) |
Medications containing this ingredient
Common questions about Chelidonium Majus
Chelidonium Majus is primarily used in clinical immunology as a diagnostic tool to identify plant-based allergies through skin testing. It is also utilized in allergen immunotherapy (allergy shots) to help desensitize patients who have severe hypersensitivity to this specific plant. Beyond its use as an allergen, some traditional medical systems use it for gallbladder and liver issues, although these uses are not standard in modern Western medicine due to safety concerns. In the United States, its most recognized pharmaceutical role is as a non-standardized allergenic extract. Always consult a healthcare provider before using any form of this extract.
The most common side effects associated with Chelidonium Majus extracts are local reactions at the site of administration, such as redness, itching, and swelling. These symptoms are typically mild and resolve on their own within a day or two. Some individuals may also experience mild gastrointestinal upset or a slight headache. However, because the extract contains potent alkaloids, more serious side effects like liver irritation can occur if systemic absorption is high. Any unusual symptoms should be reported to a doctor immediately to prevent complications.
It is strongly advised to avoid alcohol while using Chelidonium Majus, especially if it is being taken systemically. Both alcohol and the alkaloids found in Chelidonium Majus are processed by the liver and can cause hepatic stress. Combining the two significantly increases the risk of drug-induced liver injury or hepatitis. Even if you are only receiving skin tests, it is best to avoid alcohol for 24 hours to ensure your body can accurately process the extract. Discuss your alcohol consumption habits with your doctor before starting any treatment.
Chelidonium Majus is generally not recommended during pregnancy unless a specialist determines that the diagnostic necessity outweighs the potential risks. The primary concern is the risk of an anaphylactic reaction, which can lead to a dangerous drop in blood pressure and oxygen deprivation for the fetus. Additionally, there is insufficient data regarding the potential for the plant's alkaloids to cross the placenta and affect fetal development. Most healthcare providers will postpone allergy testing or immunotherapy until after delivery. Always inform your allergist if you are pregnant or planning to become pregnant.
When used for diagnostic allergy testing, Chelidonium Majus works very quickly, with a visible skin reaction typically appearing within 15 to 20 minutes. For those undergoing allergen immunotherapy, the process is much slower and requires a 'build-up' phase that can last several months. Significant reduction in allergy symptoms usually isn't noticed until the patient reaches their maintenance dose, which can take six months to a year. Consistency is key in immunotherapy for the immune system to properly desensitize. Your doctor will monitor your progress throughout this period.
If you are using Chelidonium Majus as part of an immunotherapy program, stopping suddenly will halt the desensitization process and may cause your allergies to return to their original severity. However, unlike some medications that cause physical withdrawal, there is no known withdrawal syndrome associated with stopping this plant extract. If you experience side effects like yellowing of the skin or dark urine, you must stop using it immediately and seek medical help. Always consult your allergist before making any changes to your treatment schedule. They will provide a safe plan for discontinuation if necessary.
If you miss a scheduled injection of Chelidonium Majus allergenic extract, you should contact your allergist's office as soon as possible. Missing a dose during the build-up phase of immunotherapy can increase the risk of a reaction when you resume treatment, as your body's tolerance may have slightly decreased. Depending on how much time has passed, your doctor may need to repeat a previous dose or slightly reduce the next one to ensure safety. Never attempt to 'make up' for a missed dose by taking more than prescribed. Proper scheduling is vital for the success and safety of allergy treatments.
There is currently no clinical evidence to suggest that Chelidonium Majus causes weight gain. The extract does not contain hormones or metabolic stimulants that typically lead to changes in body mass. Most side effects are related to the immune system or the liver rather than metabolic rate or appetite. If you notice unexpected weight changes while using this or any other medication, it is important to discuss them with your healthcare provider. They can help determine if the change is related to your treatment or an underlying health condition.
Chelidonium Majus can interact with several types of medications, particularly those that affect the liver or the immune system. It should not be used with other hepatotoxic drugs like high-dose acetaminophen or certain antifungals. Additionally, medications like beta-blockers can make it harder to treat a severe allergic reaction if one occurs during therapy. You must provide your healthcare provider with a complete list of all prescriptions, over-the-counter drugs, and herbal supplements you are taking. This allows them to screen for potential interactions and ensure your treatment is safe.
Chelidonium Majus is a natural plant extract, and because it is 'non-standardized,' the term 'generic' does not apply in the same way it does to synthetic drugs like ibuprofen. However, various manufacturers produce their own versions of the extract for clinical use. These extracts can vary in potency and composition because they are derived from natural sources. When prescribed for allergy treatment, your doctor will likely use a specific brand or preparation that they trust for consistency. It is not typically sold as a standard generic medication in a pharmacy setting.