Absorbine Jr. Plus Knee

For the relief of musculoskeletal pain or itching, healthcare providers generally recommend applying a thin layer of camphor-containing product to the affected area no more than 3 to 4 times daily. For cough suppression via chest rub, a thick layer is applied to the chest and throat, which may be covered with a warm, dry cloth but must remain loose to allow vapors to reach the nose and mouth.

Caution: Camphor (synthetic) is extremely toxic to children if ingested.

• Children 2 years and older: Use only under adult supervision. Apply sparingly to the affected area 3 to 4 times daily.
• Children under 2 years: Use is generally contraindicated. Consult a pediatrician before any use in infants or toddlers.

Renal Impairment

No specific dosage adjustments are typically required for topical application; however, patients with severe renal disease should avoid large-scale application to prevent systemic accumulation.

Hepatic Impairment

Since camphor is metabolized by the liver, patients with hepatic insufficiency should use the product with caution and avoid application over large surface areas.

Elderly Patients

Elderly patients may have thinner skin, which can increase systemic absorption. Use the lowest effective amount for the shortest duration possible.

• Topical Use Only: This medication is for external use only. Do not ingest.
• Application: Wash hands before and after application. Clean the skin area before applying.
• Avoid Heat: Do not use with heating pads or apply external heat to the area, as this increases the risk of burns and excessive absorption.
• Storage: Store at room temperature (20°C to 25°C) in a tightly closed container away from open flames, as camphor is highly flammable.

If a dose is missed, apply it as soon as you remember. If it is nearly time for the next application, skip the missed dose. Do not double the amount applied to compensate for a missed dose.

Signs of camphor toxicity/overdose (especially if ingested) include nausea, vomiting, abdominal pain, headache, dizziness, and in severe cases, seizures or respiratory failure. If ingestion is suspected, contact a Poison Control Center or seek emergency medical attention immediately.

> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance.

• Skin Irritation: A mild stinging, burning, or tingling sensation at the site of application.
• Erythema (Redness): Temporary reddening of the skin due to increased localized blood flow.

• Contact Dermatitis: A localized allergic reaction characterized by a red, itchy rash or small blisters.
• Dry Skin: Flaking or peeling of the skin after repeated applications.

• Hypersensitivity Reactions: Intense itching, hives, or swelling beyond the application site.
• Systemic Toxicity: Dizziness or confusion, usually only occurring with excessive topical use or application to broken skin.

> Warning: Stop taking Camphor (synthetic) and call your doctor immediately if you experience any of these.

• Seizures: Camphor is a known neurotoxin; involuntary muscle contractions or loss of consciousness require emergency care.
• Respiratory Distress: Difficulty breathing, especially in children, after inhalation or accidental ingestion.
• Anaphylaxis: Severe allergic reaction including swelling of the face, tongue, or throat and severe dizziness.
• Chemical Burns: Severe blistering or skin necrosis at the application site.

Prolonged use of camphor on large areas of the skin may lead to chronic systemic absorption, potentially causing hepatotoxicity (liver damage) or chronic neurological symptoms such as tremors or irritability.

There are currently no FDA black box warnings for topical Camphor (synthetic); however, the FDA issued a safety communication in 1982 strictly limiting the concentration of camphor in OTC products to 11% due to the high risk of seizures and death upon accidental ingestion.

Report any unusual symptoms to your healthcare provider.

Camphor (synthetic) is highly toxic if swallowed. Even small amounts (as little as 1 gram) can be fatal to a small child. Always keep products containing camphor out of the reach of children and pets.

No FDA black box warnings for Camphor (synthetic). However, strict concentration limits (11%) are enforced by the FDA for consumer safety.

• Allergic Reactions: Patients with a known sensitivity to terpenes or essential oils should avoid camphor.
• Broken or Irritated Skin: Do not apply camphor to wounds, damaged skin, or irritated areas, as this significantly increases the risk of toxic systemic absorption.
• Flammability: Camphor is highly flammable. Do not use near an open flame, sparks, or while smoking.
• Microwave Warning: Never heat camphor-containing products (like ointments) in a microwave or on a stove, as this can cause severe splattering and burns.

Routine lab tests are not typically required for short-term topical use. However, if a patient uses camphor chronically or over large areas, healthcare providers may monitor:

• Liver Function Tests (LFTs): To check for signs of hepatotoxicity.
• Neurological Assessment: To monitor for signs of central nervous system irritability.

Topical use of camphor does not typically interfere with the ability to drive or operate machinery. However, if systemic absorption occurs and causes dizziness, these activities should be avoided.

There are no known direct interactions between topical camphor and alcohol. However, excessive alcohol consumption may exacerbate the liver strain if camphor is being absorbed systemically.

There is no known withdrawal syndrome associated with Camphor (synthetic). Patients may stop use at any time if symptoms resolve or if irritation occurs.

> Important: Discuss all your medical conditions with your healthcare provider before starting Camphor (synthetic).

• Oral Camphor: Taking camphor by mouth is strictly contraindicated due to extreme toxicity and risk of death.
• Other Potent Counter-irritants: Avoid using multiple high-concentration counter-irritants (like high-dose capsicum) on the same skin area simultaneously, as this can cause severe skin damage.

• Warfarin/Anticoagulants: While topical camphor is generally safe, extensive application may theoretically interfere with clotting factors or interact with the skin's permeability for other topical agents. Monitor for increased bruising if used extensively.

• Topical NSAIDs: Using camphor alongside topical diclofenac or ibuprofen may alter the absorption rate of the NSAID. Healthcare providers recommend applying them at different times.

There are no documented food interactions with topical Camphor (synthetic). Since the drug is not intended for ingestion, dietary restrictions are generally unnecessary.

• Essential Oils: Concurrent use with other essential oils (like eucalyptus or menthol) can increase the potency of the counter-irritant effect. While often combined in commercial products, DIY mixing should be avoided to prevent skin irritation.

Camphor is not known to significantly interfere with standard blood or urine laboratory tests when used topically as directed.

For each major interaction, the mechanism typically involves pharmacodynamic synergy (increasing the effect on the skin) or altered absorption (changing how other drugs penetrate the skin). The clinical consequence is usually localized skin irritation or, in rare cases of over-application, increased systemic toxicity. The management strategy is to use the product exactly as labeled and avoid mixing with other topical treatments without medical advice.

> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking.

• Hypersensitivity: Known allergy to camphor or any components of the formulation.
• Ingestion: Camphor must never be taken orally; it is a potent poison.
• Infants: Use in infants under 2 years of age is generally contraindicated due to the risk of severe respiratory collapse and seizures.
• Broken Skin: Application to denuded or abraded skin is contraindicated due to the risk of rapid systemic absorption.

• Pregnancy and Lactation: Use should be limited to small areas for short durations only after a risk-benefit analysis by a healthcare provider.
• History of Seizures: Patients with epilepsy or a history of convulsions should use camphor with extreme caution, as systemic absorption can lower the seizure threshold.

Patients who are allergic to other terpenes, such as pinene (found in turpentine) or menthol, may experience cross-allergic reactions when using Camphor (synthetic).

> Important: Your healthcare provider will evaluate your complete medical history before prescribing Camphor (synthetic).

Camphor (synthetic) is not formally categorized by the FDA pregnancy categories (A, B, C, D, X), but it is known to cross the placenta. There is limited data on its teratogenicity in humans. Healthcare providers typically advise against extensive use during pregnancy. It should only be used if the potential benefit justifies the potential risk to the fetus.

It is unknown if topically applied camphor is excreted in human milk in significant quantities. However, it should never be applied to the breast area to prevent the infant from accidental ingestion or inhalation during nursing. Consult a healthcare provider before use while breastfeeding.

Children are uniquely susceptible to camphor toxicity. The FDA limits camphor content to 11% primarily to protect this population. Use is generally avoided in children under 2. In older children, it must be used sparingly and kept out of reach to prevent accidental ingestion, which can cause rapid-onset seizures.

Clinical studies have not identified specific differences in responses between the elderly and younger patients. However, because elderly patients may have increased skin fragility and multiple comorbidities, the lowest effective dose is recommended.

While systemic absorption is low with proper use, patients with end-stage renal disease should avoid large-scale application, as the kidneys are responsible for excreting camphor metabolites.

Patients with significant liver disease (Child-Pugh Class B or C) should use camphor cautiously, as the liver is the primary site of camphor metabolism.

> Important: Special populations require individualized medical assessment.

Camphor (synthetic) acts as a TRP channel modulator. Specifically, it is an agonist of the TRPV1 (vanilloid) and TRPV3 receptors, producing a sensation of warmth. It also activates TRPM8 (cold-sensitive) receptors, which produces a cooling sensation. By stimulating these cutaneous receptors, it induces a 'gate-control' mechanism of analgesia, where the sensory input from the camphor overrides pain signals from underlying tissues. At higher concentrations, it can also inhibit voltage-gated sodium channels, providing a mild local anesthetic effect.

Upon topical application, the onset of the cooling/warming sensation is almost immediate (within 1-5 minutes). The duration of the counter-irritant effect typically lasts for 2 to 4 hours. Tolerance does not usually develop with intermittent use, but chronic use may lead to localized skin desensitization.

| Parameter | Value |

|---|---|

| Bioavailability | High (via skin/mucous membranes) |

| Protein Binding | Not well-characterized in humans |

| Half-life | Approximately 90-120 minutes (systemic) |

| Tmax | 30-60 minutes (after topical application) |

| Metabolism | Hepatic (Hydroxylation) |

| Excretion | Renal (as glucuronide conjugates) |

• Molecular Formula: C10H16O
• Molecular Weight: 152.23 g/mol
• Solubility: Highly soluble in alcohol and oils; very slightly soluble in water.
• Structure: A bicyclic monoterpene ketone with a characteristic penetrating, pungent odor.

Camphor (synthetic) is classified as a Topical Analgesic, Counter-irritant, and Non-Standardized Plant Allergenic Extract. It is often grouped with menthol and methyl salicylate in OTC analgesic formulations.