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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Brand Name
Acidum Lacticum
Generic Name
Acidum Lacticum
Active Ingredient
Lactic Acid, Dl-Category
Vitamin C [EPC]
Variants
8
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 6 [hp_C]/1 | PELLET | ORAL | 37662-1053 |
| 200 [hp_C]/1 | PELLET | ORAL | 37662-1057 |
| 10 [hp_M]/1 | PELLET | ORAL | 37662-1060 |
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Acidum Lacticum, you must consult a qualified healthcare professional.
| 1 [hp_M]/1 | PELLET | ORAL | 37662-1059 |
| 500 [hp_C]/1 | PELLET | ORAL | 37662-1058 |
| 12 [hp_C]/1 | PELLET | ORAL | 37662-1054 |
| 30 [hp_C]/1 | PELLET | ORAL | 37662-1055 |
| 100 [hp_C]/1 | PELLET | ORAL | 37662-1056 |
Detailed information about Acidum Lacticum
Lactic Acid, Dl- is a versatile alpha-hydroxy acid used primarily as a keratolytic agent to treat hyperkeratotic skin conditions and as a pH adjuster in various pharmaceutical preparations, including parenteral solutions.
The dosage of Lactic Acid, Dl- is highly individualized and depends on the specific condition being treated and the concentration of the product prescribed.
Lactic Acid, Dl- must be used with caution in pediatric populations due to their higher surface-area-to-body-weight ratio, which increases the risk of systemic absorption.
While topical Lactic Acid, Dl- does not usually require dose adjustments for patients with kidney disease, systemic administration of lactate-containing fluids requires extreme caution. In patients with severe renal failure, the ability to excrete the metabolic byproducts of lactate may be compromised, potentially leading to fluid overload or electrolyte imbalances.
Since the liver is the primary site for the metabolism of lactate into bicarbonate, patients with significant hepatic dysfunction (e.g., cirrhosis) may not process lactate efficiently. This can lead to an accumulation of lactate in the blood. Topical use is generally safe, but systemic use should be carefully monitored.
Elderly patients often have thinner, more fragile skin. Healthcare providers may suggest less frequent application (e.g., once daily) to prevent excessive irritation or 'over-exfoliation.'
For topical formulations, proper application technique is vital for both safety and efficacy:
If you miss a dose of Lactic Acid, Dl-, apply it as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed dose and return to your regular dosing schedule. Do not 'double up' the amount applied to make up for a missed dose, as this significantly increases the risk of skin irritation.
Topical overdose typically manifests as severe skin redness, burning, peeling, or blistering. If this occurs, wash the area thoroughly with cool water and discontinue use until you consult your healthcare provider.
In the rare event of accidental ingestion, symptoms may include gastrointestinal irritation, nausea, or metabolic disturbances. Seek emergency medical attention or contact a Poison Control Center immediately.
> Important: Follow your healthcare provider's dosing instructions exactly. Do not adjust your dose or stop using the medication without first consulting your medical team.
Most patients using Lactic Acid, Dl- will experience mild localized reactions, particularly during the first few weeks of treatment as the skin adjusts to the acidic pH. These include:
Lactic Acid, Dl- is a potent pharmacological agent and must be used with an understanding of its chemical properties. It is intended for external use only. Patients must ensure that the medication does not come into contact with the eyes, as it can cause severe corneal irritation or chemical burns. If accidental eye contact occurs, flush immediately with large amounts of water for at least 15 minutes and seek ophthalmologic evaluation.
As of 2026, there are no FDA black box warnings for Lactic Acid, Dl-. It is generally recognized as safe (GRAS) when used as directed for its approved indications.
There are no absolute systemic drug-drug contraindications for topical Lactic Acid, Dl-. However, in a dermatological context, it should not be used simultaneously with other potent chemical exfoliants or 'peels' (such as high-concentration glycolic acid or TCA peels) unless under the direct supervision of a dermatologist. Combining these can lead to severe chemical burns and permanent scarring.
Lactic Acid, Dl- must NEVER be used in the following circumstances:
There are no adequate and well-controlled studies of Lactic Acid, Dl- in pregnant women. Animal reproduction studies have not been conducted. While topical absorption is relatively low, the physiological changes in pregnancy (such as increased skin vascularity) could theoretically increase systemic exposure. Lactic Acid, Dl- should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is generally recommended to avoid application to large surface areas for prolonged periods during the first trimester.
It is not known whether topically applied lactic acid is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Lactic Acid, Dl- is administered to a nursing woman. Crucially, the medication should not be applied to the breast or nipple area to prevent the nursing infant from direct oral ingestion or skin-to-skin contact with the drug.
Safety and effectiveness in pediatric patients under the age of 2 have not been established. In older children, Lactic Acid, Dl- should be used under close medical supervision. Children have a higher surface-area-to-mass ratio, making them more susceptible to systemic effects if the drug is absorbed. Healthcare providers typically recommend limited application areas and strict sun protection for pediatric patients.
Lactic Acid, Dl- is an alpha-hydroxy acid (AHA) with the chemical formula C3H6O3. Its primary mechanism of action is keratolytic. It acts as a chemical exfoliant by increasing the hydration of the skin and reducing the intercellular cohesion between corneocytes in the stratum corneum. Specifically, it interferes with the ionic bonds (calcium-dependent) that hold skin cells together. By sequestering calcium ions, it destabilizes the desmosomes, allowing the dead skin cells to shed more easily. Additionally, as a humectant, it contains hydroxyl groups that form hydrogen bonds with water, trapping moisture within the skin matrix.
The pharmacodynamic effect of Lactic Acid, Dl- is local and concentration-dependent.
Common questions about Acidum Lacticum
Lactic Acid, Dl- is primarily used to treat skin conditions characterized by dry, scaly, or thickened skin, such as ichthyosis vulgaris and xerosis. It works by softening the skin and helping to remove dead skin cells through a process called keratolysis. Additionally, it acts as a powerful moisturizer by drawing water into the skin layers. Some healthcare providers also recommend it for smoothing the small bumps associated with keratosis pilaris. It is available in various strengths, with 12% formulations being common for moderate to severe conditions.
The most frequently reported side effects are localized skin reactions, including mild stinging, burning, and redness at the site of application. These sensations are often temporary and occur most often when the medication is first started or applied to sensitive skin. Visible peeling or flaking may also occur as the medication exfoliates the dead skin layers. If these symptoms persist or become painful, you should contact your healthcare provider. Using a gentle moisturizer alongside the treatment can sometimes help manage these minor irritations.
There are no known direct interactions between alcohol consumption and the topical use of Lactic Acid, Dl-. Because the medication is applied to the skin and systemic absorption is quite low, alcohol does not interfere with how the drug works. However, it is important to note that alcohol can dehydrate the body and the skin, which might worsen the dry skin conditions you are trying to treat. For the best results, maintaining proper hydration is recommended. Always consult your doctor if you have concerns about alcohol and your specific skin health.
Lactic Acid, Dl- is classified as FDA Pregnancy Category C, meaning there is limited data from human studies. While topical absorption is low, it should only be used during pregnancy if your healthcare provider determines that the benefits outweigh the potential risks. Most dermatologists consider it relatively safe for limited use, but it is best to avoid applying it to large areas of the body. Always inform your obstetrician or dermatologist if you are pregnant or planning to become pregnant. They may suggest alternative moisturizers or a lower concentration during this time.
While you may feel an immediate improvement in skin hydration within hours of the first application, visible changes in skin texture and scaling usually take longer. Most patients begin to see a significant reduction in dryness and thickness after 2 to 4 weeks of consistent, twice-daily use. It is important to continue using the medication as directed, even if you don't see immediate results. If your condition does not improve after a month of treatment, you should consult your healthcare provider. Consistency is key to maintaining the exfoliating and hydrating benefits of this medication.
Yes, you can stop using Lactic Acid, Dl- suddenly without experiencing a 'withdrawal' syndrome, as it is not a systemic medication like a steroid. However, because it treats the symptoms of chronic skin conditions rather than curing the underlying cause, your skin scales and dryness are likely to return. Most patients find that their skin begins to feel rough or dry again within one to two weeks of stopping the medication. If you wish to stop, your doctor might suggest a maintenance schedule, such as applying it only two or three times a week. Always discuss changes to your treatment plan with a medical professional.
If you miss an application of Lactic Acid, Dl-, you should apply it as soon as you remember. If it is nearly time for your next scheduled dose, simply skip the missed application and continue with your normal routine. You should never apply double the amount of cream or lotion to make up for a missed dose. Doing so can significantly increase the risk of skin irritation, redness, and burning. Maintaining a regular schedule helps ensure the medication works effectively to keep your skin smooth and hydrated.
No, topical Lactic Acid, Dl- does not cause weight gain. The medication works locally on the skin's surface and does not enter the bloodstream in amounts large enough to affect your metabolism or weight. It is not a hormonal medication or a steroid, which are the types of drugs typically associated with weight changes. If you experience unexpected weight gain while using this product, it is likely due to other factors or medications. You should discuss any significant weight changes with your healthcare provider to identify the cause.
Lactic Acid, Dl- can generally be used with most systemic (oral) medications without any issues. However, you should be cautious when using it with other topical treatments, especially those that also exfoliate or dry the skin, such as retinoids, salicylic acid, or benzoyl peroxide. Combining these can lead to excessive irritation and damage to the skin barrier. It is best to wait at least 15-30 minutes between applying different skin products. Always provide your doctor with a full list of all skincare products and medications you are currently using.
Yes, Lactic Acid, Dl- is widely available as a generic medication, often labeled as 'Ammonium Lactate' lotion or cream in 12% concentrations. Generic versions are typically much more affordable than brand-name products like Lac-Hydrin and are required by the FDA to be bioequivalent in terms of safety and efficacy. You can find lower-concentration versions (5-10%) over-the-counter, while the 12% strength usually requires a prescription in many regions. Check with your pharmacist to see if a generic version is appropriate for your prescription.
Other drugs with the same active ingredient (Lactic Acid, Dl-)
While Lactic Acid, Dl- is generally safe for topical use, certain reactions require immediate clinical intervention.
> Warning: Stop taking Lactic Acid, Dl- and call your doctor immediately if you experience any of these:
Prolonged use of high-concentration Lactic Acid, Dl- can lead to 'thinning' of the stratum corneum. While this is the intended effect for treating hyperkeratosis, it may make the skin permanently more susceptible to environmental damage and UV radiation. Chronic irritation may also lead to the development of telangiectasias (visible small blood vessels) in sensitive individuals. It is essential to have your skin monitored periodically by a healthcare provider during long-term therapy.
No FDA black box warnings currently exist for Lactic Acid, Dl- topical preparations. However, the FDA does require a specific 'Sunburn Alert' on the labeling of all cosmetic and drug products containing alpha-hydroxy acids (AHAs). This alert warns consumers that the product may increase skin sensitivity to the sun and particularly the possibility of sunburn.
Report any unusual symptoms or persistent skin changes to your healthcare provider. Your doctor may recommend adjusting the frequency of use or switching to a different formulation if side effects become bothersome.
For standard topical use, routine laboratory monitoring (such as blood counts or liver enzymes) is not typically required. However, clinical monitoring is essential:
Topical application of Lactic Acid, Dl- does not impair the ability to drive or operate heavy machinery. There are no known sedative or cognitive effects associated with this medication.
There is no direct pharmacological interaction between topical Lactic Acid, Dl- and alcohol consumption. However, excessive alcohol use can dehydrate the skin, potentially counteracting the moisturizing benefits of the medication.
Lactic Acid, Dl- does not require a tapering period. However, if the medication is stopped abruptly, the hyperkeratotic condition (such as dry scales) may return within a few weeks. If you experience a significant 'rebound' of symptoms, consult your healthcare provider about a long-term maintenance schedule.
> Important: Discuss all your medical conditions, especially any history of skin cancer or eczema, with your healthcare provider before starting Lactic Acid, Dl-.
There are no known food interactions with topical Lactic Acid, Dl-. Diet does not affect the absorption or metabolism of the medication when applied to the skin.
For each major interaction, the mechanism is typically a pharmacodynamic interaction, where the combined effect of two skin-active agents exceeds the skin's tolerance threshold. Management strategies involve 'contact time' adjustments (washing one product off before applying the next) or 'moisture sandwiching' (applying a plain emollient between active layers).
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, including over-the-counter skincare products.
Conditions requiring careful risk-benefit analysis include:
Patients who are sensitive to other alpha-hydroxy acids (such as glycolic acid, citric acid, or malic acid) are highly likely to experience similar sensitivity to Lactic Acid, Dl-. A history of 'acid sensitivity' in cosmetic products should be reported to the healthcare provider.
> Important: Your healthcare provider will evaluate your complete medical history and perform a skin assessment before prescribing Lactic Acid, Dl-.
Clinical studies of Lactic Acid, Dl- (as 12% ammonium lactate) did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. However, geriatric skin is often physiologically different—thinner and with reduced lipid content. This may lead to an increased incidence of irritation. Physicians may suggest a 'trial period' with once-daily application for elderly patients.
For topical use, no dosage adjustment is typically necessary. For systemic use (sodium lactate), the drug is contraindicated in severe renal failure because the resulting bicarbonate cannot be effectively regulated by the kidneys, leading to a risk of metabolic alkalosis.
In patients with severe liver disease, the conversion of lactate to bicarbonate is impaired. While topical use remains safe due to low systemic levels, these patients should be monitored for signs of localized irritation, and systemic lactate therapy should be avoided.
> Important: Special populations require individualized medical assessment to ensure the safest possible treatment plan.
| Parameter | Value |
|---|---|
| Bioavailability | 5% - 12% (Topical) |
| Protein Binding | Negligible |
| Half-life | 15 - 30 minutes (Systemic) |
| Tmax | 1 - 3 hours (Topical absorption) |
| Metabolism | Hepatic (via LDH to Pyruvate) |
| Excretion | Exhaled as CO2; Renal (minor) |
Lactic Acid, Dl- is classified as a Keratolytic Agent and an Alpha-Hydroxy Acid (AHA). It is therapeutically related to glycolic acid and salicylic acid, though it is generally considered more hydrating and less irritating than glycolic acid at equivalent concentrations.