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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Agaricus Phosphorus
Brand Name
Agaricus Phosphorus
Generic Name
Agaricus Phosphorus
Active Ingredient
Amanita Muscaria Fruiting BodyCategory
Aromatic Amino Acid [EPC]
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 8 [hp_X]/mL | LIQUID | ORAL | 48951-1022 |
Detailed information about Agaricus Phosphorus
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Agaricus Phosphorus, you must consult a qualified healthcare professional.
Amanita Muscaria Fruiting Body is a complex pharmacological agent containing psychoactive alkaloids. It is classified under multiple categories including Aromatic Amino Acids and Cholinergic Muscarinic Antagonists, primarily used in allergenic extracts and specialized clinical research.
Dosage for Amanita Muscaria Fruiting Body is highly dependent on the specific clinical preparation being used. There is no "standard" oral dose for the raw fruiting body, as it is considered toxic.
Amanita Muscaria Fruiting Body extracts are generally not recommended for pediatric use unless specifically directed by a specialist in immunology. Pediatric patients are at a significantly higher risk for CNS toxicity and respiratory depression if exposed to the active alkaloids. If used for allergy testing, pediatric patients must be monitored in a facility equipped for emergency resuscitation.
Since the active alkaloids (muscimol) are primarily excreted by the kidneys, patients with a Glomerular Filtration Rate (GFR) below 30 mL/min should avoid exposure. Accumulation of the drug can lead to prolonged sedation and neurotoxicity.
While the liver is not the primary site of excretion, hepatic impairment may alter the decarboxylation rate of ibotenic acid. Caution is advised in patients with Child-Pugh Class B or C cirrhosis.
Elderly patients are more sensitive to the Anticholinergic [EPC] and Cholinergic Muscarinic Antagonist [EPC] effects. There is an increased risk of confusion, falls, and urinary retention. Dosing in this population should start at the lowest possible range.
If you miss a dose of a prescribed extract or homeopathic preparation, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up, as this increases the risk of CNS depression.
Overdose of Amanita Muscaria Fruiting Body is a medical emergency. Signs of overdose include:
Emergency Measures: If an overdose is suspected, call 911 or your local poison control center immediately. Treatment is primarily supportive. Gastric lavage and activated charcoal may be used if the ingestion was recent. Atropine may be administered by medical professionals if muscarinic symptoms (SLUDGE) are dominant.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance.
Side effects of Amanita Muscaria Fruiting Body are often dose-dependent and relate to its CNS-active alkaloids. Common experiences include:
> Warning: Stop taking Amanita Muscaria Fruiting Body and call your doctor immediately if you experience any of these.
Data on the long-term use of Amanita Muscaria Fruiting Body is limited. However, prolonged exposure to muscimol-containing substances may lead to:
No FDA black box warnings currently exist for standardized Amanita Muscaria allergenic extracts. However, the raw fruiting body is widely recognized by the CDC and WHO as a toxic botanical with significant risk of neurotoxicity and death if not handled correctly. Clinical preparations must be used only under the supervision of a qualified immunologist or physician.
Report any unusual symptoms to your healthcare provider.
Amanita Muscaria Fruiting Body is a potent substance that affects the central nervous system. It should never be used recreationally. Patients receiving standardized extracts must be monitored for at least 30 minutes following administration to ensure no immediate adverse reactions occur.
No FDA black box warnings for Amanita Muscaria Fruiting Body extracts. However, clinicians should treat the substance with the same caution as other potent neurotoxins and allergens.
Patients on long-term immunotherapy or homeopathic treatment with Amanita Muscaria Fruiting Body should undergo the following:
Amanita Muscaria Fruiting Body causes significant impairment of motor skills, reaction time, and judgment. Do not drive or operate heavy machinery for at least 24 hours after a significant dose or if you feel any lingering sedative effects.
Alcohol is strictly contraindicated. Alcohol is a GABAergic enhancer and will synergistically increase the sedative and respiratory-depressant effects of muscimol, potentially leading to fatal respiratory failure.
Sudden discontinuation after prolonged use of high-potency extracts may result in a withdrawal syndrome characterized by anxiety, insomnia, and muscle tremors. Healthcare providers should implement a tapering schedule over 1-2 weeks.
> Important: Discuss all your medical conditions with your healthcare provider before starting Amanita Muscaria Fruiting Body.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking.
Patients who are allergic to other fungi, such as Agaricus bisporus (common button mushroom) or Psilocybe species, may exhibit cross-reactivity with Amanita Muscaria Fruiting Body extracts. Skin testing should be performed with caution in these individuals.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Amanita Muscaria Fruiting Body.
Amanita Muscaria Fruiting Body is classified as FDA Pregnancy Category X (or equivalent risk). Ibotenic acid is a known neurotoxin that can cross the placental barrier. Animal studies have shown that exposure during gestation can lead to significant developmental delays and alterations in the GABAergic system of the offspring. There is also a risk of uterine contractions and potential miscarriage. Its use is strictly prohibited in pregnant women.
It is unknown if the alkaloids muscimol and muscarine are excreted in human milk. However, given their low molecular weight and lack of protein binding, excretion is highly likely. Nursing infants exposed to these compounds via breast milk may experience sedation, poor feeding, and respiratory distress. Breastfeeding should be discontinued if the mother must be treated with Amanita extracts.
The safety and efficacy of Amanita Muscaria Fruiting Body have not been established in children under the age of 12. Pediatric patients are significantly more susceptible to the excitatory effects of ibotenic acid, which often manifests as severe seizures rather than the sedation seen in adults. Use in this population is generally avoided except in specialized pediatric allergy clinics.
Clinical studies indicate that geriatric patients have a reduced clearance rate for muscimol. Furthermore, the elderly are at a higher risk for Anticholinergic [EPC] side effects, including confusion, dry mouth, and constipation. There is a significant concern for increased fall risk due to the ataxia and dizziness caused by this drug. Dose reductions of 50% are often recommended for patients over 65.
In patients with moderate renal impairment (CrCl 30-60 mL/min), the half-life of muscimol is significantly extended. Dosing frequency should be reduced. In severe impairment (CrCl < 30 mL/min), the drug is contraindicated.
No specific dose adjustments are provided for hepatic impairment, but patients should be monitored for signs of increased CNS sensitivity. Since the liver converts ibotenic acid to muscimol, liver dysfunction may theoretically delay the onset of the sedative phase while prolonging the excitatory phase.
> Important: Special populations require individualized medical assessment.
Amanita Muscaria Fruiting Body acts as a complex modulator of the autonomic and central nervous systems. The primary mechanism is the GABA-A Receptor Agonism by muscimol. Muscimol binds to the GABA-binding site on the GABA-A ionotropic receptor, increasing the frequency of chloride channel opening. This results in neuronal hyperpolarization and widespread CNS inhibition. Simultaneously, ibotenic acid acts as an NMDA Receptor Agonist, providing an excitatory counterpoint that can lead to neurotoxicity through calcium influx and oxidative stress.
The pharmacodynamic response is biphasic. The initial phase (30-90 minutes post-exposure) is dominated by the excitatory effects of ibotenic acid, characterized by stimulation and occasionally seizures. The second phase (2-5 hours post-exposure) is dominated by the inhibitory effects of muscimol, characterized by deep sleep and hallucinations. The duration of effect typically lasts 8-12 hours, though cognitive lingering can persist for 24 hours.
| Parameter | Value |
|---|---|
| Bioavailability | >80% (Oral) |
| Protein Binding | <10% |
| Half-life | 5 - 8 hours |
| Tmax | 1 - 2 hours |
| Metabolism | Decarboxylation (Ibotenic to Muscimol) |
| Excretion | Renal 90% (unchanged) |
Amanita Muscaria Fruiting Body is categorized as an Aromatic Amino Acid [EPC], Standardized Fungal Allergenic Extract [EPC], and a Cholinergic Muscarinic Antagonist [EPC] (though its muscarine content also provides agonist activity). It is related to other fungal extracts like Alternaria and Cladosporium used in allergy medicine.
Common questions about Agaricus Phosphorus
In a formal clinical setting, Amanita Muscaria Fruiting Body is primarily used to produce standardized allergenic extracts for the diagnosis and treatment of fungal allergies. These extracts help allergists identify if a patient has a hypersensitivity to specific fungal proteins through skin testing. Additionally, it is used in homeopathic medicine under the name Agaricus muscarius for various neurological conditions like tremors. It also serves as a critical research tool in neuropharmacology to study the GABA-A receptor. It is not approved for general recreational or therapeutic use due to its high toxicity profile.
The most frequent side effects reported include significant dizziness, somnolence (extreme sleepiness), and nausea. Patients often describe a feeling of intoxication similar to alcohol, accompanied by visual distortions where objects appear larger or smaller than they are. Because it affects the autonomic nervous system, increased salivation and sweating are also very common. In some cases, muscle twitches or a lack of coordination (ataxia) can occur shortly after administration. These effects typically subside within 12 to 24 hours as the drug is cleared by the kidneys.
No, you must absolutely avoid alcohol while taking any form of Amanita Muscaria Fruiting Body or its extracts. Alcohol is a potent enhancer of the GABA system, which is the same system targeted by the active alkaloid muscimol. Combining the two can lead to a dangerous synergy, resulting in severe respiratory depression, profound coma, and potentially death. Even small amounts of alcohol can significantly increase the risk of accidents due to extreme impairment of motor skills. Always wait at least 48 hours after the effects have completely worn off before consuming alcohol.
Amanita Muscaria Fruiting Body is considered unsafe during pregnancy and is generally classified in a high-risk category (Category X). The active alkaloids, particularly ibotenic acid, are known neurotoxins that can cross the placenta and interfere with the developing fetal nervous system. There is a significant risk of developmental toxicity and potential miscarriage associated with its use. Healthcare providers will not prescribe or administer this substance to pregnant individuals. If you discover you are pregnant while using an extract, contact your doctor immediately.
The onset of action for Amanita Muscaria Fruiting Body is relatively rapid, typically beginning within 30 to 90 minutes after oral ingestion or administration of an extract. The initial effects are often excitatory, involving a feeling of agitation or increased energy. This is followed by a peak effect between 2 and 3 hours, where the sedative and hallucinogenic properties become most prominent. The total duration of the clinical effect usually lasts between 6 and 10 hours. However, because the alkaloids are cleared renally, the timeline can be extended in individuals with impaired kidney function.
If you have been using Amanita Muscaria extracts or homeopathic preparations on a long-term basis, you should not stop taking them suddenly without consulting your doctor. Sudden discontinuation can lead to rebound effects in the central nervous system, such as increased anxiety, tremors, and insomnia. This is because the brain may have adjusted to the constant GABAergic stimulation provided by the drug. A healthcare provider will typically recommend a gradual tapering of the dose over one to two weeks. This allows the neurotransmitter systems to return to their baseline state safely.
If a dose of a prescribed Amanita preparation is missed, it should be taken as soon as the patient remembers, provided it is not too close to the next scheduled dose. If it is almost time for the next dose, the missed dose should be skipped entirely to avoid the risk of cumulative toxicity. You should never take two doses at the same time to make up for a missed one. Doubling the dose significantly increases the risk of CNS depression and respiratory issues. If you are unsure, contact your pharmacist or prescribing physician for specific guidance.
There is currently no clinical evidence to suggest that Amanita Muscaria Fruiting Body causes weight gain. The drug is typically used for short-term diagnostic purposes or in highly diluted homeopathic forms, neither of which are associated with metabolic changes or increased appetite. In fact, due to the common side effect of nausea and gastrointestinal upset, some patients may experience a temporary decrease in food intake. If you notice significant weight changes while using this substance, it is likely due to another underlying condition or medication. Discuss any weight concerns with your healthcare provider.
Amanita Muscaria Fruiting Body has many serious drug interactions, particularly with medications that affect the brain. It should not be taken with benzodiazepines, sleep aids, opioids, or any other CNS depressants due to the risk of fatal respiratory failure. It also interacts with anticholinergic drugs, which can complicate the side effect profile. Because it is cleared by the kidneys, other drugs that affect renal function may also change how the body processes Amanita. Always provide your doctor with a full list of your current medications before starting treatment.
Amanita Muscaria Fruiting Body is a natural biological substance, so it is not 'generic' in the way synthetic drugs are. However, various manufacturers produce standardized fungal extracts and homeopathic preparations that are essentially equivalent. These are often sold under the botanical name Agaricus muscarius or as generic 'Fungal Allergenic Extract.' While the active components are the same, the concentration and purity can vary between manufacturers. It is important to use the specific brand or preparation recommended by your specialist to ensure consistent dosing and safety.
Other drugs with the same active ingredient (Amanita Muscaria Fruiting Body)