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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Clematis Vitalba Flos, Helianthemum Nummularium, Flos, Impatiens Glandulifera, Flos, Ornithogalum Umbellatum, Flos, Prunus Cerasifera, Flos
Brand Name
Bio Res Q
Generic Name
Clematis Vitalba Flos, Helianthemum Nummularium, Flos, Impatiens Glandulifera, Flos, Ornithogalum Umbellatum, Flos, Prunus Cerasifera, Flos
Active Ingredient
Clematis Vitalba FlowerCategory
Standardized Insect Venom Allergenic Extract [EPC]
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 6 [hp_X]/mL | LIQUID | ORAL | 43857-0108 |
Detailed information about Bio Res Q
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Bio Res Q, you must consult a qualified healthcare professional.
Clematis Vitalba Flower is a botanical substance utilized as a non-standardized plant allergenic extract and characterized by its adrenergic alpha and beta agonist properties for immunotherapy and physiological support.
Dosage for Clematis Vitalba Flower extracts must be highly individualized based on the patient's sensitivity and the specific clinical indication.
Clematis Vitalba Flower extracts may be used in children, typically aged 5 years and older, who exhibit significant allergic symptoms that are not well-controlled by standard medications.
Specific dose adjustments for renal impairment are not typically required for allergenic extracts, as the protein load is minimal. However, patients with severe renal disease should be monitored for fluid balance if adrenergic effects are anticipated.
No specific adjustments are required for patients with liver disease, as the metabolism of the extract is primarily proteolytic rather than hepatic.
Elderly patients (65+) require cautious dosing. The adrenergic agonist properties of Clematis Vitalba may place additional strain on the cardiovascular system. Healthcare providers may choose a slower induction phase to monitor for tachycardia (rapid heart rate) or hypertension (high blood pressure).
If you miss a scheduled immunotherapy injection:
An overdose of Clematis Vitalba Flower extract (either through incorrect volume or incorrect concentration) is a medical emergency.
> Important: Follow your healthcare provider's dosing instructions exactly. Do not adjust your dose or frequency without medical guidance, as this significantly increases the risk of life-threatening reactions.
Most patients undergoing treatment with Clematis Vitalba Flower extracts will experience some form of local reaction. These are generally mild and expected as the body adjusts to the allergen.
> Warning: Stop taking Clematis Vitalba Flower and call your doctor immediately or seek emergency care if you experience any of these symptoms of anaphylaxis.
With prolonged use (3-5 years of immunotherapy), the goal is permanent immune tolerance. However, long-term risks may include:
Clematis Vitalba Flower extracts, like other allergenic extracts, can cause severe, life-threatening systemic allergic reactions, including anaphylaxis.
Report any unusual symptoms or side effects to your healthcare provider promptly. Keeping a log of local reactions can help your doctor adjust your dose safely.
Clematis Vitalba Flower is a potent biological substance. It is not a standard pharmaceutical drug but a complex extract that interacts directly with the immune and autonomic nervous systems. Patients must be aware that the primary risk is an overreaction of the immune system. This treatment is a long-term commitment, often requiring 3 to 5 years of consistent therapy to achieve lasting results.
No FDA black box warnings for Clematis Vitalba Flower. (Note: While many allergenic extracts carry class-wide warnings regarding anaphylaxis, specific branded products containing Clematis Vitalba may have varying labeling requirements. Always refer to the specific package insert provided by the manufacturer.)
To ensure safety, your healthcare provider will perform the following:
Clematis Vitalba Flower does not typically cause sedation. However, if a patient experiences a systemic reaction or receives epinephrine for a reaction, they should not drive or operate heavy machinery until they have fully recovered and been cleared by a physician.
Alcohol consumption should be avoided on the day of an immunotherapy injection. Alcohol causes vasodilation (widening of blood vessels), which can increase the speed at which the allergen is absorbed into the bloodstream, potentially increasing the risk of a systemic reaction.
Immunotherapy should not be stopped suddenly without consulting your doctor. While there is no 'withdrawal' syndrome, stopping treatment early will result in the return of allergic symptoms. If treatment must be discontinued due to severe side effects, your doctor will provide a plan for managing your allergies with alternative medications.
> Important: Discuss all your medical conditions, including any history of heart problems or respiratory issues, with your healthcare provider before starting Clematis Vitalba Flower.
For each major interaction, the mechanism typically involves either pharmacodynamic synergy (both substances affecting the heart/lungs in the same way) or interference with emergency treatment (beta-blockers vs. epinephrine). Management usually involves switching to safer alternative medications before starting Clematis Vitalba Flower therapy.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, especially those for blood pressure, heart rhythm, or depression.
Clematis Vitalba Flower must NEVER be used in the following circumstances:
Conditions requiring careful risk-benefit analysis include:
Patients allergic to Clematis Vitalba may also react to other members of the Ranunculaceae (Buttercup) family, such as Anemone or Ranunculus. If you have had a severe reaction to any of these plants, inform your allergist, as cross-reactivity is possible.
> Important: Your healthcare provider will evaluate your complete medical history, including your lung function and cardiovascular health, before prescribing Clematis Vitalba Flower.
Pregnancy Category C. There are no adequate and well-controlled studies of Clematis Vitalba Flower in pregnant women.
It is not known whether the components of Clematis Vitalba Flower extract are excreted in human milk. Because the active components are large proteins that are likely digested in the infant's gastrointestinal tract, the risk to a nursing infant is considered low. However, breastfeeding mothers should be monitored for any unusual systemic reactions that could indirectly affect milk production or the ability to care for the infant.
Patients over age 65 are at higher risk for adverse effects from the adrenergic properties of Clematis Vitalba.
No specific dose adjustments are required. However, patients with end-stage renal disease (ESRD) should be monitored for their ability to clear the metabolic byproducts of the protein extract, although this is rarely a clinical concern.
No adjustments are needed for patients with liver cirrhosis or hepatitis, as the liver does not play a primary role in the clearance of these allergenic proteins.
> Important: Special populations require individualized medical assessment. Always inform your specialist if you are pregnant, planning to become pregnant, or have underlying kidney or liver issues.
Clematis Vitalba Flower acts as a biological response modifier. Its primary action is the induction of immune tolerance. By introducing the allergen via the subcutaneous route, the extract bypasses the normal mucosal barriers. This promotes the development of Regulatory T-cells (Tregs), which secrete anti-inflammatory cytokines like IL-10 and TGF-beta. These cytokines suppress the Th2 allergic response and signal B-cells to switch production from IgE to IgG4.
Additionally, the Adrenergic alpha and beta-Agonist [MoA] involves the extract's constituents binding to adrenergic receptors. Alpha-1 binding triggers the Gq protein pathway, increasing intracellular calcium and causing smooth muscle contraction (vasoconstriction). Beta-2 binding triggers the Gs protein pathway, increasing cyclic AMP (cAMP) and causing smooth muscle relaxation in the bronchioles.
| Parameter | Value |
|---|---|
| Bioavailability | Low (Subcutaneous/Local) |
| Protein Binding | High (to specific antibodies) |
| Half-life | Proteins: Hours; Immunological effect: Years |
| Tmax | 1–3 hours (for systemic absorption) |
| Metabolism | Proteolysis (Protease enzymes) |
| Excretion | Renal (Metabolites) |
Clematis Vitalba Flower belongs to the Standardized and Non-Standardized Allergenic Extracts therapeutic class. It is related to other plant extracts like Ragweed, Timothy Grass, and Oak extracts used in immunotherapy.
Common questions about Bio Res Q
Clematis Vitalba Flower is primarily used as an allergenic extract for the diagnosis and treatment of specific allergies. In a clinical setting, it is used in skin prick testing to identify if a patient is allergic to this specific plant pollen. If an allergy is confirmed, the extract is used in immunotherapy (allergy shots) to help desensitize the patient's immune system over time. This process involves giving gradually increasing doses of the flower extract to reduce symptoms like sneezing, itchy eyes, and congestion. Additionally, because it has adrenergic properties, it may be found in certain specialized formulations to support blood pressure or airway function, though this is less common.
The most common side effects are localized reactions at the site of the injection. These include redness, itching, and swelling (wheals) that typically appear shortly after the shot is given. Some patients may also feel mild fatigue or have a temporary increase in their usual allergy symptoms, such as a runny nose or sneezing. These reactions are usually mild and resolve within 24 hours. However, because it is an allergen, there is always a risk of a more serious systemic reaction, which is why patients are monitored closely by medical staff after each dose.
It is strongly recommended that you avoid drinking alcohol on the days you receive a Clematis Vitalba Flower injection. Alcohol causes your blood vessels to dilate, which can speed up the absorption of the allergen into your bloodstream. This rapid absorption increases the risk of a systemic allergic reaction or anaphylaxis. Furthermore, alcohol can mask the early symptoms of a reaction, such as dizziness or flushing, making it harder for you or your doctor to identify an emergency. For your safety, wait at least 24 hours after your injection before consuming alcohol.
The use of Clematis Vitalba Flower during pregnancy is generally approached with extreme caution. While the extract itself is not known to cause birth defects, a severe allergic reaction (anaphylaxis) in the mother can be very dangerous for the baby, as it can cut off the baby's oxygen supply. Most doctors will not start a new course of allergy shots during pregnancy for this reason. However, if you are already on a stable maintenance dose and have not had any bad reactions, your doctor may allow you to continue the treatment at that same dose. Always inform your allergist immediately if you become pregnant.
Allergen immunotherapy with Clematis Vitalba Flower is a slow process that requires patience. Most patients do not see a significant improvement in their allergy symptoms until they reach their 'maintenance dose,' which usually takes 3 to 6 months of weekly injections. Significant and lasting relief typically occurs after 12 months of consistent treatment. For the best long-term results—meaning your allergies stay gone even after you stop the shots—a full course of 3 to 5 years of therapy is usually required. It is not a 'quick fix' like an antihistamine pill, but rather a long-term modification of your immune system.
Yes, you can stop taking Clematis Vitalba Flower injections at any time without experiencing physical withdrawal symptoms like those seen with some other medications. However, stopping the treatment before the recommended 3-to-5-year mark will likely result in your allergy symptoms returning over time. If you stop during the early 'build-up' phase, you will likely see no benefit at all. If you need to stop due to side effects or life changes, talk to your doctor first. They may be able to adjust your schedule or switch you to a different form of treatment to maintain the progress you have made.
If you miss a dose of your Clematis Vitalba Flower immunotherapy, you should contact your allergist's office as soon as possible to reschedule. Do not try to 'double up' on your next dose. If you only miss a few days, your doctor will likely give you your usual dose. However, if you miss several weeks, your immune system may become more sensitive again, and giving the usual dose could be dangerous. In such cases, your doctor will likely reduce your dose and then gradually build it back up again to ensure your safety.
There is no clinical evidence to suggest that Clematis Vitalba Flower extracts cause weight gain. Unlike certain medications like oral corticosteroids or some antidepressants, allergenic extracts do not affect your metabolism or appetite in a way that leads to weight changes. The amount of protein and active ingredients in each injection is extremely small. If you notice significant weight changes while undergoing immunotherapy, it is likely due to other factors, such as changes in your activity level, diet, or other medications you may be taking.
Clematis Vitalba Flower can be taken with many common medications, but there are some very important exceptions. You must avoid taking beta-blockers (often used for blood pressure or heart issues) while receiving this treatment, as they can make allergic reactions much worse and prevent life-saving epinephrine from working. Other medications like MAO inhibitors or certain antidepressants can also interact with the adrenergic properties of the extract. Always provide your doctor with a full list of every medication, supplement, and herbal remedy you use to ensure there are no dangerous interactions.
Clematis Vitalba Flower is typically available as a non-standardized biological extract rather than a 'generic' in the traditional sense. Because it is a complex biological product derived from plants, different manufacturers may produce their own versions, which are often considered comparable but not identical. These are usually referred to by their botanical name or as part of a specific manufacturer's line of allergenic extracts. Your allergist will typically select a high-quality extract from a reputable laboratory, and it is important to stay with the same brand throughout your treatment to ensure consistent dosing.
Other drugs with the same active ingredient (Clematis Vitalba Flower)