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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Chlophedianol Hydrochloride, Dexbrompheniramine Maleate, Pseudoephedrine Hydrochloride
Brand Name
Chlo Tuss
Generic Name
Chlophedianol Hydrochloride, Dexbrompheniramine Maleate, Pseudoephedrine Hydrochloride
Active Ingredient
ChlophedianolCategory
Other
Salt Form
Hydrochloride
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 12.5 mg/5mL | LIQUID | ORAL | 12830-762 |
Detailed information about Chlo Tuss
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Chlo Tuss, you must consult a qualified healthcare professional.
Chlophedianol is a centrally acting non-narcotic antitussive used to suppress dry, non-productive coughs. It works by increasing the cough threshold in the brain's medulla oblongata.
For the relief of non-productive cough in adults and adolescents aged 12 years and older, the standard dosage of chlophedianol hydrochloride is typically 25 mg administered orally every 6 to 8 hours.
Chlophedianol must be dosed with extreme caution in children. Dosage is strictly based on age:
Specific dosage adjustment guidelines for patients with kidney disease have not been established by the FDA. However, because the drug is primarily excreted through the kidneys, patients with significant renal impairment should use chlophedianol with caution. A lower frequency of dosing may be necessary to prevent drug accumulation and toxicity.
As chlophedianol is metabolized by the liver, individuals with severe hepatic dysfunction (liver failure or cirrhosis) should consult a doctor before use. Impaired metabolism can lead to elevated plasma levels of the drug, increasing the risk of CNS side effects like hallucinations or extreme drowsiness.
Patients over the age of 65 may be more sensitive to the anticholinergic effects of chlophedianol. This population is at a higher risk for confusion, dizziness, and urinary retention. Starting at the lower end of the dosing range is often advisable.
If you miss a dose of chlophedianol, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose to catch up, as this increases the risk of adverse effects like dizziness or CNS excitation.
Signs of a chlophedianol overdose can be serious and may include:
In the event of a suspected overdose, contact your local poison control center or seek emergency medical attention immediately. Bring the medication container with you to the emergency room.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose or the frequency of administration without medical guidance. Persistent coughs lasting more than 7 days require a formal medical evaluation.
Chlophedianol is generally well-tolerated when used at recommended doses, but its pharmacological profile can lead to several common side effects. Many of these are related to its mild anticholinergic activity.
These effects are less frequent but may be more bothersome to the patient:
While rare, certain side effects of chlophedianol require immediate intervention by a healthcare professional.
> Warning: Stop taking Chlophedianol and call your doctor immediately if you experience any of these:
Chlophedianol is intended for short-term use (typically no more than 7 consecutive days). Prolonged use is not recommended because:
There are currently no FDA black box warnings for chlophedianol. It is considered a safe medication for the general population when used according to the label instructions. However, its presence in many multi-symptom products means patients must be vigilant about the other ingredients in their medication (such as acetaminophen or antihistamines) which may have their own specific safety warnings.
Report any unusual symptoms to your healthcare provider. If side effects persist or become bothersome, your doctor may suggest an alternative antitussive such as benzonatate or dextromethorphan.
Chlophedianol is a potent cough suppressant that must be used with an understanding of its effects on the central nervous system. The most important safety consideration is the nature of the cough being treated. A cough that produces a large amount of mucus (a productive cough) is the body's way of clearing the lungs. Suppressing such a cough can lead to a buildup of secretions, potentially resulting in pneumonia or worsening of chronic lung diseases.
Patients should also be aware that chlophedianol is often a 'hidden' ingredient in multi-symptom cold medicines. Always check the 'Active Ingredients' section of the Drug Facts label to ensure you are not taking multiple products containing chlophedianol or other medications with similar side effects, such as first-generation antihistamines (e.g., diphenhydramine).
No FDA black box warnings for Chlophedianol. Unlike some opioid-based cough syrups containing codeine, chlophedianol does not have a high potential for abuse or a warning regarding life-threatening respiratory depression in children, though it still carries age-based restrictions.
For short-term use of OTC chlophedianol, routine laboratory monitoring (like blood counts or liver enzymes) is generally not required for healthy individuals. However, if a patient is prescribed chlophedianol for an extended period or has pre-existing conditions, a healthcare provider may monitor:
Chlophedianol may cause marked drowsiness or blurred vision. Do not drive a car, operate heavy machinery, or engage in potentially dangerous activities until you know how this medication affects you. The risk of impairment is significantly higher during the first few doses.
Avoid alcohol while taking chlophedianol. Alcohol significantly increases the sedative effects of the medication, leading to extreme drowsiness, impaired coordination, and an increased risk of accidents. Combining the two can also increase the risk of respiratory depression in sensitive individuals.
There is no known withdrawal syndrome associated with the discontinuation of chlophedianol when used at therapeutic doses for short durations. You can typically stop taking the medication as soon as your cough improves. If your cough returns or worsens after stopping the medication, consult your doctor, as this may indicate an underlying infection that requires antibiotics or other treatments.
> Important: Discuss all your medical conditions with your healthcare provider before starting Chlophedianol, especially if you have a history of high blood pressure, thyroid disease, or diabetes, as many combination products contain decongestants that can affect these conditions.
Chlophedianol is not known to significantly interfere with most common blood or urine laboratory tests. However, it is always important to inform laboratory personnel and your physician of all medications you are taking, as some components in combination syrups (like Vitamin C or certain dyes) can occasionally cause false readings in glucose or occult blood tests.
For each major interaction, the management strategy usually involves avoiding the combination entirely (as with MAOIs) or reducing the dose of the sedative agent and monitoring the patient for signs of excessive CNS depression.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking. Many people forget to mention 'natural' supplements, which can have powerful interactions with cough and cold medicines.
Absolute contraindications are conditions where the risk of using chlophedianol clearly outweighs any potential benefit. In these cases, the drug must never be used.
Relative contraindications require a careful risk-benefit analysis by a healthcare professional. Chlophedianol may be used, but with extreme caution and monitoring.
While chlophedianol is chemically distinct from most other antitussives, patients who are highly sensitive to other antihistamines or anticholinergic drugs (like diphenhydramine) may be more likely to experience side effects from chlophedianol. There is no documented cross-allergenicity between chlophedianol and opioid antitussives like codeine, making it a viable alternative for patients with a codeine allergy.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Chlophedianol. Always provide a full list of your diagnosed medical conditions and any past adverse reactions to medications.
Chlophedianol is generally classified under FDA Pregnancy Category C. This means that animal reproduction studies have not been conducted, and there are no adequate and well-controlled studies in pregnant women. It is unknown whether chlophedianol can cause fetal harm when administered to a pregnant woman or if it can affect reproduction capacity.
It is not known whether chlophedianol is excreted in human milk. Because many drugs are excreted in breast milk and because of the potential for serious adverse reactions in nursing infants (such as unusual excitement or irritability), a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. If use is necessary, the infant should be closely monitored for signs of sedation or poor feeding.
Chlophedianol is approved for use in children as young as 2 years old, but with strict weight and age-based dosing. However, the FDA and the American Academy of Pediatrics (AAP) have issued warnings regarding the use of OTC cough and cold medicines in very young children.
Clinical studies of chlophedianol did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. However, clinical experience suggests that the elderly are more prone to:
In patients with a Glomerular Filtration Rate (GFR) below 30 mL/min, the clearance of chlophedianol metabolites may be significantly reduced. While no specific 'dialysis' data exists, it is prudent to monitor these patients for signs of CNS toxicity and consider extending the dosing interval to 12 hours instead of 6-8 hours.
Patients with a Child-Pugh score of Class B or C (moderate to severe impairment) should use chlophedianol with caution. The liver's ability to process the drug is diminished, which can lead to higher-than-expected blood levels. Healthcare providers may recommend using a lower dose or choosing an antitussive with a different metabolic pathway.
> Important: Special populations require individualized medical assessment. Pregnant women and parents of young children should always consult a pediatrician or obstetrician before using any cough suppressant.
Chlophedianol is a centrally acting antitussive. Its primary molecular target is the medulla oblongata in the brainstem. It acts as a depressant on the medullary cough center, effectively 'numbing' the central trigger point for the cough reflex. Unlike dextromethorphan, which primarily acts on sigma-1 receptors, chlophedianol's exact receptor binding profile is less clearly defined but is known to involve mild inhibition of cholinergic receptors (muscarinic antagonism). This anticholinergic action contributes to its ability to reduce secretions and provides a mild local anesthetic effect on the peripheral sensory nerve endings in the respiratory mucosa.
The dose-response relationship of chlophedianol is linear within the therapeutic range (6.25 mg to 25 mg). The time to onset is approximately 30 to 90 minutes. A unique pharmacodynamic feature of chlophedianol is its duration of effect; while many cough suppressants last 4 hours, chlophedianol typically remains effective for 6 to 8 hours. Tolerance (the need for higher doses to achieve the same effect) is not commonly reported with short-term therapeutic use, though the drug does not address the underlying cause of the cough (e.g., infection or inflammation).
| Parameter | Value |
|---|---|
| Bioavailability | High (estimated >70%) |
| Protein Binding | Moderate (approx. 40-60%) |
| Half-life | 4 - 6 hours |
| Tmax | 1.5 - 2 hours |
| Metabolism | Hepatic (CYP-mediated) |
| Excretion | Renal (Primary) |
Chlophedianol is classified as a centrally acting non-narcotic antitussive. It is grouped with other cough suppressants like dextromethorphan and benzonatate. It is distinct from narcotic antitussives such as codeine and hydrocodone, which are controlled substances with a higher risk profile for addiction and respiratory depression.
Common questions about Chlo Tuss
Chlophedianol is primarily used for the temporary relief of a dry, non-productive cough. This type of cough is often caused by minor throat and bronchial irritation associated with the common cold or inhaled irritants. Unlike expectorants, which help clear mucus, Chlophedianol works by suppressing the brain's cough reflex. It is particularly useful for coughs that interfere with sleep or daily activities. It is frequently found in combination with other cold medications to treat multiple symptoms at once.
The most common side effects of Chlophedianol include drowsiness, dizziness, and dry mouth. Some patients may also experience mild nausea or a feeling of lightheadedness. Because it has mild anticholinergic properties, it can sometimes cause blurred vision or a slight increase in heart rate. These effects are usually mild and go away as the medication leaves your system. If you experience extreme sleepiness or confusion, you should stop taking the medication and contact your doctor.
No, you should avoid drinking alcohol while taking Chlophedianol. Alcohol can significantly increase the sedative effects of the medication, leading to dangerous levels of drowsiness and impaired coordination. Combining alcohol with any centrally acting cough suppressant increases the risk of accidents and can potentially slow down your breathing. It is safest to wait until the medication has completely cleared your system before consuming alcoholic beverages. Always check with your pharmacist if you are unsure about interactions.
Chlophedianol is classified as FDA Pregnancy Category C, meaning its safety in pregnant women has not been fully established. There are no comprehensive studies in humans to determine if it causes fetal harm. Most healthcare providers recommend avoiding unnecessary medications during pregnancy, especially in the first trimester. If your cough is severe, your doctor may suggest safer alternatives or determine if the benefits of Chlophedianol outweigh the risks. Always consult your obstetrician before taking any over-the-counter cough medicine while pregnant.
Chlophedianol typically begins to work within 30 to 90 minutes after oral administration. Its peak effect is usually reached within 2 hours of taking the dose. One of the main advantages of Chlophedianol is its long duration of action, providing relief for approximately 6 to 8 hours. This makes it an effective option for overnight cough suppression. If your symptoms do not improve within a few days of starting the medication, you should consult a healthcare professional.
Yes, you can stop taking Chlophedianol suddenly as it is not known to cause physical dependence or withdrawal symptoms when used as directed. Since it is intended for the short-term symptomatic relief of a cough, you should stop taking it once your cough has subsided. However, if you stop the medication and your cough returns or is accompanied by a fever or rash, it may indicate an underlying infection. In such cases, you should seek medical advice rather than restarting the medication on your own.
If you miss a dose of Chlophedianol, take it as soon as you remember, provided it is not almost time for your next dose. If the next dose is only a few hours away, skip the missed dose and continue with your regular schedule. Never take two doses at once to make up for a missed one, as this increases the risk of side effects like extreme dizziness or hallucinations. Keeping a consistent schedule helps maintain the cough-suppressant effect throughout the day. If you frequently miss doses, consider setting a reminder on your phone.
There is no clinical evidence to suggest that Chlophedianol causes weight gain. Because it is intended for short-term use (usually less than a week), it does not have the metabolic effects associated with long-term medications like steroids or certain antidepressants. If you notice unusual weight changes or swelling while taking a cough medicine, it is likely due to another factor or a different ingredient in a combination product. Always discuss any unexpected physical changes with your healthcare provider. Maintaining a healthy diet and hydration is important during any viral illness.
Chlophedianol can interact with several types of medications, particularly those that affect the central nervous system. It should never be taken with Monoamine Oxidase Inhibitors (MAOIs) due to the risk of a dangerous spike in blood pressure. You should also be cautious when taking it with other sedatives, sleep aids, or antihistamines, as these can worsen drowsiness. Because Chlophedianol is often found in multi-symptom products, you must ensure you aren't 'double-dosing' on other ingredients like acetaminophen. Always provide your doctor or pharmacist with a full list of your current medications.
Yes, Chlophedianol is available as a generic medication, although it is most commonly found as part of generic combination cough and cold syrups. You can find it in various store-brand versions of multi-symptom relief liquids. Generic versions are required by the FDA to have the same strength, quality, and efficacy as the original brand-name products. When looking for a generic, check the 'Active Ingredients' list on the back of the bottle for 'Chlophedianol HCl.' This is often a more cost-effective way to treat cough symptoms compared to name-brand equivalents.
Other drugs with the same active ingredient (Chlophedianol)