Loading...
Loading...
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Clotrimazole And Betamethasone Dipropionate
Brand Name
Clotrimazole And Betamethasone Dipropionate
Generic Name
Clotrimazole And Betamethasone Dipropionate
Active Ingredient
Betamethasone DipropionateCategory
Azole Antifungal [EPC]
Variants
17
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| .5 mg/g | CREAM | TOPICAL | 68462-298 |
| .5 mg/g | CREAM | TOPICAL | 71205-524 |
| .5 mg/g | CREAM | TOPICAL | 50090-4876 |
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Clotrimazole And Betamethasone Dipropionate, you must consult a qualified healthcare professional.
| .5 mg/g | CREAM | TOPICAL | 72189-182 |
| .5 mg/g | CREAM | TOPICAL | 50090-6474 |
| .5 mg/g | CREAM | TOPICAL | 63629-8758 |
| .5 mg/g | CREAM | TOPICAL | 70518-2352 |
| .5 mg/g | CREAM | TOPICAL | 0472-0379 |
| .5 mg/g | CREAM | TOPICAL | 16714-496 |
| .5 mg/mL | LOTION | TOPICAL | 51672-1308 |
| .5 mg/g | CREAM | TOPICAL | 50090-3121 |
| .5 mg/g | CREAM | TOPICAL | 50090-0741 |
+ 5 more variants
Detailed information about Clotrimazole And Betamethasone Dipropionate
Betamethasone dipropionate is a high-potency synthetic corticosteroid used topically to treat inflammatory and pruritic skin conditions. It belongs to the glucocorticoid class and works by suppressing the immune response and reducing inflammation.
For most corticosteroid-responsive dermatoses, the standard adult dosage involves applying a thin film of betamethasone dipropionate (0.05%) to the affected skin areas once or twice daily.
Betamethasone dipropionate is generally not recommended for children under the age of 12. Pediatric patients have a larger skin surface area relative to their body mass, which makes them much more susceptible to systemic toxicity, including HPA axis suppression, Cushing's syndrome, and linear growth retardation.
If a healthcare provider determines that use in a child is necessary, it must be used at the lowest effective dose for the shortest possible duration (often limited to 5-7 days). Use in the diaper area is strictly contraindicated as diapers act as occlusive dressings, drastically increasing absorption.
No specific dosage adjustments are typically required for topical application in patients with kidney disease, as systemic absorption is minimal. However, if large areas are treated or occlusion is used, monitoring for systemic effects is advised.
In patients with severe liver disease, the metabolism of systemically absorbed betamethasone may be reduced. While topical use is generally safe, prolonged use over large surface areas should be approached with caution, as it may lead to higher systemic levels of the drug.
Geriatric patients often have thinner skin (atrophy), which increases the risk of both local side effects (like bruising or skin tears) and systemic absorption. Providers usually recommend using the least potent formulation that is effective and avoiding long-term use.
If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular schedule. Do not 'double up' or apply extra medication to make up for a missed application.
Acute overdosage via topical application is rare. However, chronic overdosage (using too much for too long) can lead to systemic absorption sufficient to produce Cushing’s syndrome (moon face, buffalo hump, central obesity) and HPA axis suppression. If the medication is accidentally swallowed, contact a Poison Control Center or seek emergency medical help immediately.
> Important: Follow your healthcare provider's dosing instructions exactly. Do not apply this medication to the face, underarms, or groin unless specifically told to do so by your doctor, as these areas are prone to skin thinning.
Because betamethasone dipropionate is a high-potency steroid, local skin reactions are common, especially during the first few days of use. These may include:
These effects are usually mild and often resolve as the skin adjusts to the medication.
Betamethasone dipropionate is a potent medication that must be used with caution. It is intended for external use only and should never be used in the eyes, mouth, or vagina. Patients should be aware that the potency of this drug makes it unsuitable for 'minor' skin irritations like diaper rash or simple dry skin.
No FDA black box warnings have been issued for Betamethasone Dipropionate as of 2026. However, its high potency necessitates careful monitoring to prevent systemic toxicity.
While topical interactions are rare, betamethasone dipropionate should not be used simultaneously with other topical corticosteroids on the same skin area. Using multiple steroids increases the risk of skin atrophy and systemic absorption without providing additional therapeutic benefit.
If significant systemic absorption occurs, betamethasone dipropionate may interact with:
Betamethasone dipropionate must NEVER be used in the following circumstances:
Betamethasone dipropionate is classified as FDA Pregnancy Category C. Studies in animals have shown that corticosteroids can be teratogenic (cause birth defects like cleft palate) when administered systemically or topically in high doses. There are no adequate and well-controlled studies in pregnant women.
During pregnancy, this medication should be used only if the potential benefit justifies the potential risk to the fetus. If used, it should not be applied in large amounts or for long periods. It is generally avoided during the first trimester unless absolutely necessary.
It is not known whether topical application of betamethasone dipropionate results in sufficient systemic absorption to produce detectable quantities in breast milk. However, systemically administered corticosteroids do pass into breast milk. To minimize risk, nursing mothers should not apply the medication to the breast or nipple area to prevent the infant from accidentally ingesting the drug. Consult your doctor to weigh the benefits of treatment against the risks to the nursing infant.
Betamethasone dipropionate is a fluorinated corticosteroid. Its primary mechanism involves the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. These proteins control the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes, by inhibiting the release of their common precursor, arachidonic acid. Furthermore, it stabilizes lysosomal membranes, preventing the release of proteolytic enzymes that damage tissues during inflammation.
The pharmacodynamics of betamethasone dipropionate are characterized by its anti-inflammatory, antipruritic, and vasoconstrictive actions. The 'Vasoconstrictor Assay' is often used to determine the potency of topical steroids; betamethasone dipropionate produces significant blanching (whitening) of the skin, indicating high potency. The onset of action for itching relief is typically within 24–48 hours, while visible reduction in redness and swelling may take 3–7 days.
| Parameter | Value |
|---|---|
Common questions about Clotrimazole And Betamethasone Dipropionate
Betamethasone dipropionate is primarily used to treat various inflammatory skin conditions such as psoriasis, eczema (atopic dermatitis), and allergic contact dermatitis. It works by reducing the redness, swelling, and intense itching associated with these disorders. Because it is a high-potency steroid, it is typically reserved for moderate to severe cases that do not respond to milder treatments. It is available in several forms, including creams, ointments, and lotions, to suit different skin types and body locations. Your doctor will determine the best formulation based on the thickness of your skin and the severity of the flare.
The most common side effects are local skin reactions at the site of application, such as burning, stinging, or itching. These sensations are usually temporary and occur shortly after the medication is applied. Some patients may also notice localized dryness or a slight change in skin color (lightening). If these symptoms persist or become severe, it is important to contact your healthcare provider. Using the medication for longer than recommended can lead to more serious issues like skin thinning or stretch marks.
There is no known direct interaction between topical betamethasone dipropionate and alcohol consumption. However, alcohol can act as a vasodilator and may worsen the redness or inflammation associated with conditions like psoriasis or rosacea. For some individuals, alcohol is a known 'trigger' that can cause skin flares to become more severe. While a moderate amount of alcohol is unlikely to interfere with the medication's effectiveness, it is best to observe how your skin reacts. Always follow your doctor's general lifestyle recommendations for managing your specific skin condition.
Betamethasone dipropionate is classified as Pregnancy Category C, meaning its safety in pregnant women has not been fully established. Animal studies have shown that high doses of corticosteroids can cause birth defects, although these effects are less likely with topical use than with oral use. It should only be used during pregnancy if the potential benefits outweigh the risks to the developing fetus. Doctors usually recommend using the lowest potency possible for the shortest duration if treatment is necessary. Always consult your obstetrician or dermatologist before using any steroid medication while pregnant.
Most patients begin to feel relief from itching and irritation within 24 to 48 hours of the first application. However, visible improvements in skin redness, scaling, and thickness may take several days to a week to become apparent. If you do not see any improvement in your skin condition after two weeks of consistent use, you should contact your healthcare provider. Do not continue using the medication beyond the prescribed timeframe without medical advice, as this increases the risk of side effects. Consistency in application is key to achieving the best results.
If you have been using betamethasone dipropionate for a short period (less than two weeks), you can usually stop without issues. However, if you have been using it daily for an extended period or on large areas of the body, stopping suddenly can cause a 'rebound' effect where your skin condition returns worse than before. This is because the skin becomes accustomed to the steroid's anti-inflammatory action. Your doctor will typically suggest 'tapering' the dose by applying it every other day or switching to a weaker steroid before stopping completely. Always follow the specific discontinuation plan provided by your medical professional.
If you miss a dose, apply the medication as soon as you remember. If it is nearly time for your next scheduled application, skip the missed dose and continue with your regular routine. You should never apply a double amount of the cream or ointment to make up for a missed dose, as this increases the risk of skin irritation and systemic absorption. Keeping your applications at roughly the same time each day can help you remember. If you frequently miss doses, consider setting a reminder on your phone to ensure treatment consistency.
Weight gain is not a typical side effect of topical betamethasone dipropionate when used correctly and in small amounts. However, if the medication is used excessively over large areas of the body for a long time, enough of the drug can be absorbed into the bloodstream to cause systemic side effects. This can lead to Cushing's syndrome, which is characterized by weight gain in the face (moon face) and abdomen. To avoid this, use only the amount prescribed by your doctor and avoid covering the treated area with plastic wrap or bandages unless instructed. If you notice rapid weight gain, consult your doctor immediately.
Betamethasone dipropionate can generally be used alongside most oral medications, but you should inform your doctor about all drugs you are taking. Interactions are most likely to occur if the steroid is absorbed systemically, which can happen with heavy or prolonged use. For example, it may interact with medications for diabetes by raising blood sugar levels. You should also avoid using other topical steroid creams on the same area of skin unless specifically directed by your healthcare provider. Combining different topical products can change how much of the steroid is absorbed into your skin.
Yes, betamethasone dipropionate is widely available as a generic medication in various forms, including cream, ointment, and lotion. Generic versions are required by the FDA to have the same active ingredient, strength, and effectiveness as the brand-name versions (such as Diprolene). Choosing the generic version can often significantly reduce the cost of your treatment. Your pharmacist can help you determine if a generic equivalent is available for the specific brand your doctor prescribed. Both brand and generic versions require a prescription from a licensed healthcare provider.
Other drugs with the same active ingredient (Betamethasone Dipropionate)
While rare with topical use, systemic absorption can lead to serious complications.
> Warning: Stop taking Betamethasone Dipropionate and call your doctor immediately if you experience any of the following:
Prolonged use of betamethasone dipropionate (typically longer than 4 weeks) can lead to a phenomenon known as Tachyphylaxis, where the skin becomes 'tolerant' to the drug and it stops working. Additionally, long-term use can lead to Topical Steroid Withdrawal (TSW), characterized by intense redness, burning, and skin peeling when the medication is stopped. To prevent this, doctors often recommend 'pulse therapy' (using the drug for a few days on and a few days off) or a gradual tapering of the dose.
Currently, there are no FDA black box warnings for betamethasone dipropionate. However, the FDA requires strict labeling regarding the risk of HPA axis suppression in pediatric patients and the potential for ocular side effects.
Report any unusual symptoms, especially changes in vision or signs of systemic illness, to your healthcare provider immediately.
If you are using high-potency betamethasone dipropionate over large areas or for long periods, your doctor may order the following tests:
Betamethasone dipropionate is not known to affect the ability to drive or operate machinery. It does not cause drowsiness or impair cognitive function.
There are no known direct interactions between topical betamethasone dipropionate and alcohol. However, alcohol can sometimes trigger flares of skin conditions like psoriasis or rosacea, so moderation is advised for general skin health.
Do not stop using this medication abruptly if you have been using it for more than two weeks. Sudden discontinuation can cause a 'rebound' flare of your skin condition. Your healthcare provider will provide a tapering schedule, which may involve applying the medication less frequently or switching to a lower-potency steroid before stopping completely.
> Important: Discuss all your medical conditions, especially any history of cataracts, glaucoma, or circulation problems, with your healthcare provider before starting Betamethasone Dipropionate.
Betamethasone dipropionate can interfere with several diagnostic tests:
For each interaction, the management strategy usually involves monitoring for increased side effects or reduced efficacy and adjusting the frequency of application. Always inform your doctor if you are using other topical products, including cosmetics or sunscreens, on the treated area.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, as well as any other topical creams you use.
Conditions requiring careful risk-benefit analysis include:
Patients who are allergic to one member of the 'corticosteroid' family may experience cross-reactivity with others. Specifically, those sensitive to betamethasone valerate or dexamethasone are at a higher risk of reacting to betamethasone dipropionate.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Betamethasone Dipropionate to ensure it is safe for your specific situation.
Use in pediatric patients under 12 years of age is generally not recommended. Children are at a higher risk for HPA axis suppression and Cushing’s syndrome due to their high skin-surface-area-to-body-weight ratio. There have been reported cases of intracranial hypertension (increased pressure around the brain) in children using topical steroids. If used, treatment must be closely monitored by a pediatrician.
Clinical studies have not identified significant differences in responses between the elderly and younger patients. However, because elderly patients are more likely to have thin, atrophic skin and may be taking multiple other medications, they should use the smallest amount of betamethasone dipropionate necessary. There is an increased risk of 'steroid purpura' (easy bruising) in this population.
No dosage adjustment is required for topical use. However, in cases of severe renal failure where the skin barrier might be compromised (uremic pruritus), increased monitoring for systemic steroid effects is recommended.
Since systemically absorbed betamethasone is metabolized by the liver, patients with severe hepatic impairment (Child-Pugh Class C) should be monitored for signs of steroid excess (Cushingoid features) if the medication is used over large surface areas or for long durations.
> Important: Special populations require individualized medical assessment to ensure the safest possible treatment outcome.
| Protein Binding | ~64% (Albumin/CBG) |
| Half-life | 35 - 54 hours (Systemic) |
| Tmax | Variable (Topical) |
| Metabolism | Hepatic (CYP3A4) |
| Excretion | Renal (>90%), Fecal (<5%) |
Betamethasone dipropionate is a high-potency Group II (or Group I if augmented) Topical Corticosteroid. It is more potent than hydrocortisone (Group VII) and triamcinolone acetonide (Group IV), but similar in potency to clobetasol propionate (Group I).