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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Niacinamide
Brand Name
Derladie Herbalextract Bodysolution Mist
Generic Name
Niacinamide
Active Ingredient
NiacinamideCategory
Adenosine Receptor Agonist [EPC]
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 3 g/100mL | LIQUID | VAGINAL | 82083-0023 |
Detailed information about Derladie Herbalextract Bodysolution Mist
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Derladie Herbalextract Bodysolution Mist, you must consult a qualified healthcare professional.
Niacinamide (Nicotinamide) is a water-soluble form of Vitamin B3 essential for cellular energy production and DNA repair, commonly used for pellagra and inflammatory skin conditions.
For the treatment of active pellagra, healthcare providers typically prescribe 50 mg to 100 mg orally three to four times daily. The total daily dose usually ranges from 300 mg to 500 mg depending on the severity of symptoms.
Based on the landmark ONTRAC study, the standard dose for high-risk individuals is 500 mg twice daily. This regimen should be maintained long-term, as the protective effects diminish once the medication is discontinued.
Topical formulations containing 4% to 5% niacinamide are typically applied to affected areas twice daily after cleansing.
Pediatric dosing for pellagra is highly individualized based on age and weight. Typical ranges are 50 mg to 300 mg daily in divided doses. Niacinamide should only be administered to children under the direct supervision of a pediatrician.
No specific dosage adjustments are generally required for mild to moderate renal impairment; however, caution is advised in patients with end-stage renal disease due to the accumulation of metabolites.
Use with caution in patients with active liver disease. While niacinamide is less hepatotoxic than nicotinic acid, high doses can still stress hepatic function.
No specific age-related adjustments are standard, but providers should consider the overall health and renal function of the patient.
If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up.
Signs of acute overdose may include severe nausea, vomiting, dizziness, and potential liver enzyme elevations. In case of suspected overdose, contact a poison control center or seek emergency medical attention immediately.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance.
Niacinamide is generally very well-tolerated. When taken at standard doses, side effects are minimal. Some patients may experience:
> Warning: Stop taking Niacinamide and call your doctor immediately if you experience any of these:
Prolonged use of high-dose niacinamide (over 1.5 grams daily) may lead to persistent elevations in liver enzymes. Regular monitoring by a healthcare provider is necessary for those on long-term, high-dose therapy.
No FDA black box warnings currently exist for Niacinamide. It is considered safe for the general population when used within established Recommended Dietary Allowance (RDA) or prescribed therapeutic ranges.
Report any unusual symptoms to your healthcare provider.
Niacinamide should be used with caution in individuals with a history of liver disease, gallbladder disease, or gout. While it is safer than nicotinic acid regarding cardiovascular effects and flushing, it is still a pharmacologically active substance that can influence metabolic pathways.
No FDA black box warnings for Niacinamide.
For patients taking therapeutic doses (e.g., 1,000 mg/day or more) for extended periods, healthcare providers may recommend:
Niacinamide is not known to impair the ability to drive or operate heavy machinery. However, if you experience dizziness, avoid these activities until the symptom resolves.
Chronic alcohol consumption can deplete B-vitamin stores, including niacinamide. Conversely, excessive alcohol use while taking high doses of niacinamide may increase the risk of liver strain. It is best to limit alcohol intake during therapy.
There is no known withdrawal syndrome associated with niacinamide. However, if used for skin cancer prevention, the protective benefits stop almost immediately upon discontinuation. Always discuss stopping the medication with your doctor first.
> Important: Discuss all your medical conditions with your healthcare provider before starting Niacinamide.
There are no absolute drug-drug contraindications where Niacinamide must never be used; however, certain combinations require extreme caution.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking.
Patients who have experienced severe reactions to Nicotinic Acid (Niacin) should be closely monitored when taking Niacinamide, although many patients who cannot tolerate the 'flush' of niacin can safely take niacinamide.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Niacinamide.
FDA Pregnancy Category: C (at pharmacological doses). At Recommended Dietary Allowance (RDA) levels, niacinamide is considered safe and essential during pregnancy. However, high therapeutic doses (e.g., for skin cancer prevention) have not been extensively studied in pregnant women. It should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus.
Niacinamide is naturally present in human breast milk. Supplemental use at RDA levels is considered safe. The effects of high-dose maternal supplementation on the nursing infant are not well-documented; therefore, caution and medical consultation are advised for doses exceeding the RDA.
Niacinamide is approved for use in children for the treatment of pellagra. It is generally safe when used at appropriate age-based doses. It is not recommended for pediatric use in skin cancer prevention or acne unless specifically directed by a specialist, as long-term safety data in children for these indications are limited.
Clinical studies have not identified significant differences in response between elderly and younger patients. However, because elderly patients are more likely to have decreased renal function or be taking multiple medications (polypharmacy), healthcare providers should monitor for potential drug interactions and renal clearance issues.
Niacinamide metabolites are excreted renally. In patients with significant kidney disease, these metabolites may accumulate. While not typically toxic, dosage reduction or increased monitoring may be necessary in Stage 4 or 5 Chronic Kidney Disease (CKD).
Niacinamide should be avoided in patients with severe hepatic impairment (Child-Pugh Class C). In mild to moderate impairment, frequent monitoring of liver enzymes is required if therapeutic doses are prescribed.
> Important: Special populations require individualized medical assessment.
Niacinamide acts as a precursor to the essential cofactors NAD+ and NADP+. These molecules are vital for the transfer of electrons in redox reactions. Specifically, it supports the function of Sirtuins (enzymes involved in longevity and stress response) and PARP (enzymes involved in DNA repair). By maintaining cellular NAD+ pools, niacinamide prevents the 'energy crisis' in cells exposed to UV radiation, thereby facilitating DNA repair and reducing the expression of inflammatory mediators.
The onset of action for pellagra symptoms is rapid (24-48 hours). For inflammatory skin conditions, the pharmacodynamic effect on sebum and cytokines typically requires 4 to 8 weeks of consistent dosing. Unlike niacin, niacinamide does not significantly alter lipid profiles (cholesterol or triglycerides) at standard doses.
| Parameter | Value |
|---|---|
| Bioavailability | ~100% (Oral) |
| Protein Binding | <25% |
| Half-life | 1 - 2 hours |
| Tmax | 0.5 - 1 hour |
| Metabolism | Hepatic (N-methylation to MNA) |
| Excretion | Renal (>90% as metabolites) |
Niacinamide is classified as a Vitamin B Complex Member and a Vitamin B3 Analog. In the EPC system, it is categorized as an Adenosine Receptor Agonist [EPC] due to its modulatory effects on adenosine signaling pathways.
Common questions about Derladie Herbalextract Bodysolution Mist
Niacinamide is primarily used to treat and prevent pellagra, a serious condition caused by Vitamin B3 deficiency. In dermatology, it is widely used topically to treat inflammatory acne and improve the skin's barrier function. It is also increasingly prescribed off-label by doctors to help prevent certain types of non-melanoma skin cancers in high-risk individuals. Additionally, it may be used as a supportive treatment for autoimmune blistering diseases like bullous pemphigoid. Always consult your healthcare provider to see if it is appropriate for your specific health needs.
Most people take niacinamide without experiencing any significant side effects. When side effects do occur, they are usually mild and involve the digestive system, such as nausea, gas, or bloating. If you are using a topical version, you might notice slight redness, itching, or a stinging sensation on the skin. Unlike regular niacin, niacinamide does not cause the uncomfortable skin flushing or redness. If you experience any severe symptoms like yellowing of the skin or eyes, you should contact your doctor immediately.
It is generally recommended to limit alcohol consumption while taking therapeutic doses of niacinamide. Both alcohol and high doses of niacinamide are processed by the liver, and combining them can increase the workload and potential strain on this organ. Chronic alcohol use also interferes with the absorption of B vitamins, which could make the supplement less effective. For those taking standard over-the-counter doses, occasional moderate alcohol consumption is usually not a concern. However, you should discuss your specific alcohol intake with your healthcare provider.
Niacinamide is considered safe and essential during pregnancy when taken at the Recommended Dietary Allowance (RDA) levels found in prenatal vitamins. However, the safety of high-dose 'pharmacological' levels (such as 500 mg or more) has not been thoroughly established for pregnant women. Because high doses could potentially affect fetal development, they should only be used if a doctor determines the benefits clearly outweigh the risks. Always inform your obstetrician about any supplements you are taking. Your doctor will help determine the safest dose for you and your baby.
The time it takes to see results depends entirely on the condition being treated. For vitamin deficiency (pellagra), systemic symptoms often begin to improve within 24 to 48 hours of starting treatment. If you are using niacinamide for acne or skin texture, it typically takes 4 to 8 weeks of consistent daily use to see a visible reduction in inflammation. For skin cancer prevention, the protective effects are ongoing but require long-term adherence to the twice-daily schedule. Do not stop the medication prematurely if you don't see immediate results.
Yes, you can generally stop taking niacinamide suddenly without experiencing withdrawal symptoms, as it is a water-soluble vitamin. However, if you are taking it for a specific medical reason, such as preventing skin cancer or treating a deficiency, the benefits will stop as soon as the medication is discontinued. In the case of skin cancer prevention, studies show that the risk of new lesions returns to baseline levels shortly after stopping the supplement. It is always best to consult your healthcare provider before ending any prescribed treatment regimen.
If you miss a dose of niacinamide, you should take it as soon as you remember. If it is almost time for your next scheduled dose, simply skip the missed one and continue with your regular timing. You should never take two doses at the same time to make up for a missed one, as this can increase the risk of stomach upset. Maintaining a consistent level of the vitamin in your system is important for its effectiveness, especially for skin cancer prevention. Setting a daily reminder on your phone can help you stay on track.
There is currently no clinical evidence to suggest that niacinamide causes weight gain in humans. As a B-vitamin, it is involved in energy metabolism and helping your body convert food into fuel, rather than promoting fat storage. Some very high-dose animal studies have looked at metabolic changes, but these do not translate to weight gain in typical human use. If you notice unexpected weight changes while taking this medication, it is likely due to another factor or underlying condition. You should discuss any significant weight changes with your healthcare provider.
Niacinamide can interact with certain medications, so it is important to provide your doctor with a full list of what you are taking. It is known to increase the levels of the seizure medication carbamazepine in the blood, which could lead to toxicity. It may also have mild interactions with blood thinners or diabetes medications. While it is safe to take with most other vitamins, you should be careful not to exceed the total recommended daily limit for Vitamin B3. Your pharmacist can check for specific interactions with your current prescriptions.
Yes, niacinamide is widely available as a generic medication and as an over-the-counter dietary supplement. Because it is a form of Vitamin B3, it is produced by many different manufacturers and is generally very affordable. Generic versions are required by the FDA to have the same quality and strength as brand-name versions. You can find it in various forms, including single-ingredient tablets, B-complex formulations, and topical skin care products. Your healthcare provider can recommend a high-quality brand or prescribe a specific strength if needed.
Other drugs with the same active ingredient (Niacinamide)