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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Brand Name
Eelhoe Cica Cooling Sun Stick
Generic Name
Titanium Dioxide
Active Ingredient
Centella Asiatica TriterpenoidsCategory
Other
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| .019 mg/19mg | STICK | TOPICAL | 85064-003 |
Detailed information about Eelhoe Cica Cooling Sun Stick
References used for this content
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Eelhoe Cica Cooling Sun Stick, you must consult a qualified healthcare professional.
Centella Asiatica Triterpenoids are a purified fraction of triterpenes used primarily for chronic venous insufficiency and wound healing. They belong to the class of botanical venotonics and dermatological agents.
The dosage of Centella Asiatica Triterpenoids (TTFCA) varies significantly based on the condition being treated and the specific formulation used. It is critical to use standardized extracts to ensure consistent intake of the active molecules.
Centella Asiatica Triterpenoids are not generally recommended for use in children under the age of 18. There is a lack of robust clinical data regarding the safety and efficacy of systemic triterpenoid supplementation in the pediatric population. Topical use for minor skin irritations may be considered by a pediatrician, but oral administration should be avoided unless specifically directed by a specialist.
There are currently no specific dosage adjustment guidelines for patients with kidney disease. However, since a portion of the metabolites is excreted renally, patients with Stage 4 or 5 Chronic Kidney Disease (CKD) should exercise caution and consult their nephrologist before use.
Because the liver is involved in the metabolism of triterpenoids, individuals with active liver disease (such as hepatitis or cirrhosis) should avoid these supplements or use them only under strict medical monitoring. There have been rare reports of hepatotoxicity associated with Centella asiatica herb, though it is unclear if this extends to the purified triterpenoid fraction.
No specific dose reductions are typically required for the elderly. In fact, most clinical trials for venous insufficiency have focused on older populations. However, healthcare providers should consider the overall medication profile of the patient to avoid potential interactions with blood pressure or blood-thinning medications.
If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up, as this may increase the risk of gastrointestinal side effects.
Signs of an oral overdose may include extreme drowsiness, dizziness, or severe nausea. In the event of an accidental large ingestion, contact your local poison control center or seek emergency medical attention immediately. While triterpenoids have a low acute toxicity profile, supportive care for gastrointestinal distress or sedation may be necessary.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose or stop the treatment without medical guidance, especially if you are treating chronic vascular conditions.
Centella Asiatica Triterpenoids are generally well-tolerated, but some individuals may experience mild side effects. The most frequently reported issues include:
> Warning: Stop taking Centella Asiatica Triterpenoids and call your doctor immediately if you experience any of these symptoms, as they may indicate a severe reaction or organ stress:
There is limited data on the continuous use of Centella Asiatica Triterpenoids beyond 6 to 12 months. Long-term use should be punctuated by "washout periods" or regular medical reviews. Potential long-term concerns include:
No FDA black box warnings currently exist for Centella Asiatica Triterpenoids, as they are not regulated as a prescription drug in the United States. However, healthcare providers in jurisdictions where it is a registered medicine emphasize the importance of monitoring liver health in patients with pre-existing hepatic conditions.
Report any unusual symptoms, even if they seem minor, to your healthcare provider to ensure your treatment remains safe and effective.
Centella Asiatica Triterpenoids (TTFCA) should be used with caution, particularly by individuals with underlying health conditions or those taking multiple medications. While often perceived as a "natural" remedy, these triterpenoids have potent biological activity and can influence various physiological systems, including liver metabolism and the central nervous system.
There are currently no FDA black box warnings for Centella Asiatica Triterpenoids. In the United States, they are primarily marketed as dietary supplements, which are regulated differently than prescription medications. However, this does not imply that the substance is without risk; users should adhere to recommended dosages and consult healthcare professionals.
If you are taking Centella Asiatica Triterpenoids for a chronic condition like venous insufficiency, your healthcare provider may recommend the following:
Because Centella Asiatica Triterpenoids can cause drowsiness or dizziness in some individuals, you should observe how you react to the first few doses before driving or operating heavy machinery. If you experience any impairment in alertness, avoid these activities and consult your doctor.
Alcohol should be consumed with extreme caution while taking these triterpenoids. Both alcohol and Centella can have sedative effects, and their combination may lead to excessive sleepiness. Furthermore, since both substances are processed by the liver, concurrent use may increase the risk of hepatic stress.
There is no evidence of a specific withdrawal syndrome associated with Centella Asiatica Triterpenoids. However, for patients treating chronic venous insufficiency, stopping the medication may lead to a return of symptoms such as leg swelling and pain. It is best to taper off or stop under the guidance of a healthcare provider who can suggest alternative management strategies.
> Important: Discuss all your medical conditions, especially liver disease or planned surgeries, with your healthcare provider before starting Centella Asiatica Triterpenoids.
While there are no absolute contraindications with specific drugs that result in immediate fatality, the following combinations are strongly discouraged due to the risk of severe organ stress:
For each major interaction, the mechanism usually involves either shared metabolic pathways in the liver or additive pharmacodynamic effects on the central nervous system. Management typically involves dose adjustment of the primary medication or discontinuation of the supplement.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking to prevent dangerous interactions.
Centella Asiatica Triterpenoids must NEVER be used in the following circumstances:
Conditions requiring a careful risk-benefit analysis by a physician include:
As mentioned, cross-sensitivity is possible with other plants in the Apiaceae family. If you react to celery or fennel, use Centella with extreme caution. There is no known cross-sensitivity between Centella triterpenoids and synthetic venotonics like diosmin or hesperidin.
> Important: Your healthcare provider will evaluate your complete medical history, including any history of liver issues or allergies, before prescribing or recommending Centella Asiatica Triterpenoids.
Oral administration of Centella Asiatica Triterpenoids is generally avoided during pregnancy. There is insufficient human data to rule out teratogenicity (birth defects). Furthermore, historical records in traditional medicine suggest that Centella asiatica may act as a uterine stimulant, potentially increasing the risk of miscarriage. In the first trimester, when organogenesis (organ formation) is occurring, the risk is theoretically highest. Use in fertility treatments is not recommended as some animal studies have suggested a potential reduction in female fertility with very high doses.
It is unknown whether Centella Asiatica Triterpenoids or their metabolites are excreted in human breast milk. Because of the lack of safety data and the potential for sedative effects in the nursing infant, breastfeeding women are generally advised to avoid oral supplementation. Topical application to the breast area should be avoided to prevent the infant from direct oral ingestion during feeding.
Centella Asiatica Triterpenoids are not approved for use in children under 18 years of age. The primary concern is the lack of long-term safety data regarding growth and development. While topical use for minor scrapes is common in some cultures, systemic use for any condition should only occur under the direction of a pediatric specialist.
Elderly patients are the primary demographic for Centella Asiatica Triterpenoids, particularly for the management of chronic venous insufficiency. While effective, the following concerns apply:
In patients with mild to moderate renal impairment, no specific dose adjustments are typically mandated, but monitoring is advised. In severe renal failure (GFR < 30 mL/min), the excretion of metabolites may be significantly delayed. Dialysis clearance of these triterpenoids has not been studied.
Centella Asiatica Triterpenoids are relatively contraindicated in patients with significant hepatic impairment (Child-Pugh Class B or C). The liver's reduced ability to process the aglycones could lead to systemic accumulation and increased risk of side effects. If use is deemed necessary, LFTs should be performed every 2-4 weeks.
> Important: Special populations require individualized medical assessment to weigh the benefits of treatment against these specific risks.
Centella Asiatica Triterpenoids (TTFCA) act primarily as modulators of connective tissue. Their molecular mechanism involves the stimulation of fibroblasts in the extracellular matrix. Specifically, asiaticoside and asiatic acid trigger the phosphorylation of Smad proteins, which are intracellular signaling transducers for the Transforming Growth Factor-beta (TGF-β) receptor. This activation leads to increased transcription of genes responsible for Type I and Type III collagen production.
In venous tissue, this results in a reinforced "collagenous cuff" around the veins, reducing distensibility and preventing the pathological remodeling seen in chronic venous insufficiency. Additionally, these triterpenoids have been shown to inhibit the activity of lysosomal enzymes and matrix metalloproteinases (MMPs), which are often overactive in chronic inflammatory states and contribute to tissue degradation.
The pharmacodynamic effect of Centella is characterized by a slow onset and a cumulative benefit. In venous insufficiency, the reduction in capillary filtration (the movement of fluid out of the blood vessels) is typically observed after 2 to 4 weeks of consistent dosing. The duration of effect after stopping the medication can last for several weeks, although symptoms eventually return if the underlying vascular pathology is not addressed. There is no evidence of pharmacological tolerance (the need for higher doses over time) for the venotonic effects.
| Parameter | Value |
|---|---|
| Bioavailability | ~10-15% (highly variable) |
| Protein Binding | ~45-60% |
| Half-life | 2.2 to 5.4 hours (Asiatic Acid) |
| Tmax | 2 to 4 hours |
| Metabolism | Hepatic; Gut microflora (hydrolysis) |
| Excretion | Fecal (Major), Renal (Minor) |
Centella Asiatica Triterpenoids are classified as Venotonics (or phlebotonics) when used systemically and as Cicatrizants (wound-healing agents) when used topically. They are often grouped with other botanical extracts like horse chestnut seed extract (aescin) and butcher's broom (ruscus), though their specific mechanism of collagen modulation is distinct.
Common questions about Eelhoe Cica Cooling Sun Stick
Centella Asiatica Triterpenoids are primarily used to treat chronic venous insufficiency (CVI), a condition where the veins have trouble sending blood from the limbs back to the heart. This often results in symptoms like leg swelling, pain, and heaviness. Additionally, these triterpenoids are widely used in dermatology to promote wound healing and reduce the appearance of scars, including keloids and hypertrophic scars. Some healthcare providers also suggest them for improving microcirculation in patients with diabetes. It is important to use a standardized extract to ensure you are receiving the correct therapeutic amount of the active triterpenes.
The most common side effects reported by patients taking oral Centella Asiatica Triterpenoids include mild gastrointestinal distress, such as nausea or stomach cramps. Some individuals may also experience a mild sedative effect or drowsiness, especially at higher doses. When applied topically as a cream, the most common side effects are localized skin irritation, itching, or a mild burning sensation. Most of these side effects are transient and resolve once the body adjusts to the supplement or the application is stopped. If side effects persist or worsen, you should consult your healthcare provider for further guidance.
It is generally advised to avoid or strictly limit alcohol consumption while taking Centella Asiatica Triterpenoids. Both alcohol and these triterpenoids are processed by the liver, and combining them may increase the risk of liver strain or hepatotoxicity. Furthermore, Centella can have mild sedative properties that may be significantly amplified by alcohol, leading to excessive drowsiness or impaired coordination. If you have a history of heavy alcohol use, you should discuss this with your doctor before starting this supplement. Safety is the priority when combining any botanical extract with alcohol.
Centella Asiatica Triterpenoids are generally not recommended for oral use during pregnancy. There is a lack of comprehensive clinical trials to confirm their safety for the developing fetus, and traditional medical knowledge suggests they may act as a uterine stimulant, which could potentially increase the risk of miscarriage. While topical use for minor skin issues might be considered safer, it should still only be done under the supervision of an obstetrician. Most healthcare providers recommend avoiding any unnecessary supplements during pregnancy to ensure the highest level of safety. Always consult your doctor before taking any new substance while pregnant.
Centella Asiatica Triterpenoids do not provide immediate relief and typically require consistent use over several weeks. For chronic venous insufficiency, most clinical studies show that significant improvements in leg swelling and pain begin to appear after 4 to 8 weeks of daily treatment. In terms of wound healing or scar management, the effects may be visible within a few weeks, but the full remodeling of scar tissue can take several months. Patience and consistency are key when using these triterpenoids. If you do not see any improvement after two months of use, you should consult your healthcare provider to re-evaluate your treatment plan.
Yes, you can generally stop taking Centella Asiatica Triterpenoids suddenly, as they are not known to cause physical dependence or a specific withdrawal syndrome. However, if you are taking them to manage a chronic condition like venous insufficiency, you may find that your symptoms, such as leg swelling and pain, return shortly after discontinuation. It is often better to discuss stopping the supplement with your doctor so they can monitor your condition and suggest other ways to manage your symptoms. For topical use, stopping suddenly will simply halt the progress of the skin-healing benefits. Always follow professional medical advice when ending a course of treatment.
If you miss a dose of Centella Asiatica Triterpenoids, take it as soon as you remember. However, if it is nearly time for your next scheduled dose, it is better to skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once to make up for the one you missed, as this could increase the likelihood of experiencing side effects like nausea or drowsiness. Maintaining a consistent level of the compound in your system is important for the best results, so try to take your doses at the same time each day. Using a pill organizer or phone reminder can help you stay on track.
There is no clinical evidence to suggest that Centella Asiatica Triterpenoids cause weight gain. These compounds do not contain significant calories, nor do they appear to affect appetite or metabolic rate in a way that would lead to an increase in body fat. In fact, because they help reduce edema (fluid retention) in the legs, some patients might notice a very slight decrease in weight or a reduction in limb girth as excess fluid is cleared. If you experience sudden or unexplained weight gain while taking this supplement, it is likely due to another cause and should be discussed with your healthcare provider. Always monitor your health holistically when starting new supplements.
Centella Asiatica Triterpenoids can interact with several types of medications, so caution is necessary. They may enhance the effects of sedatives, leading to increased sleepiness, and could potentially interfere with blood sugar or cholesterol medications. Most importantly, they should not be taken with other drugs that can stress the liver, such as certain antifungals or high-dose pain relievers. Because of these potential interactions, it is vital to provide your doctor or pharmacist with a full list of all medications and supplements you are currently taking. They can help you determine if Centella is a safe addition to your regimen. Never start a new supplement without professional medical clearance.
Centella Asiatica Triterpenoids are available under various brand names in different parts of the world, such as Madecassol or Centellase, but they are also widely available as generic or store-brand dietary supplements. When looking for a generic version, it is crucial to ensure the product is standardized to contain a specific percentage of triterpenoids (usually 40% to 100% of the total triterpenic fraction). Non-standardized Gotu Kola powders may not contain enough of the active ingredients to be effective for clinical conditions like venous insufficiency. Always check the label for 'TTFCA' or a list of the four specific triterpenoids to ensure you are getting a high-quality product. Your pharmacist can help you select a reputable brand.
Other drugs with the same active ingredient (Centella Asiatica Triterpenoids)