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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Adenosinum Ciclophosphoricum - Lilium Tigrinum - Melatonin - Sus Scrofa Adrenal Gland - Sus Scrofa Corpus Luteum - Sus Scrofa Hypothalamus - Sus Scrofa Ovary - Sus Scrofa Pancreas - Sus Scrofa Pineal Gland - Sus Scrofa Pituitary Gland - Sus Scrofa Thymus - Thyroid -
Brand Name
Guna-fem
Generic Name
Adenosinum Ciclophosphoricum - Lilium Tigrinum - Melatonin - Sus Scrofa Adrenal Gland - Sus Scrofa Corpus Luteum - Sus Scrofa Hypothalamus - Sus Scrofa Ovary - Sus Scrofa Pancreas - Sus Scrofa Pineal Gland - Sus Scrofa Pituitary Gland - Sus Scrofa Thymus - Thyroid -
Active Ingredient
Adenosine CyclicCategory
Non-Standardized Food Allergenic Extract [EPC]
Salt Form
Phosphate
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 6 [hp_X]/30mL | SOLUTION/ DROPS | ORAL | 17089-231 |
Detailed information about Guna-fem
References used for this content
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Guna-fem, you must consult a qualified healthcare professional.
Adenosine Cyclic, often referred to as Adenosine Cyclic Phosphate (cAMP), is a vital intracellular second messenger involved in various physiological processes, including its use in non-standardized allergenic extracts and metabolic regulation.
The dosage of Adenosine Cyclic is highly individualized and depends entirely on the indication for which it is being used.
Adenosine Cyclic may be used in pediatric populations, particularly for allergy testing and immunotherapy. However, the safety and efficacy in children are strictly managed by pediatric allergists.
Because the metabolites of Adenosine Cyclic are excreted via the kidneys, patients with significant renal impairment (reduced kidney function) may require lower doses or extended intervals between administrations. Close monitoring of uric acid levels may be necessary, as the breakdown of adenosine can contribute to hyperuricemia (high levels of uric acid in the blood).
While the liver is not the primary site of cAMP degradation (which occurs via phosphodiesterases in the blood and tissues), patients with severe hepatic impairment (liver disease) should be monitored for secondary metabolic imbalances that could affect how the body responds to the drug.
Older adults often have a higher prevalence of cardiovascular disease. Since Adenosine Cyclic can influence heart rate and blood pressure (via its beta-adrenergic agonist properties), elderly patients should be started on the lowest possible dose with frequent monitoring of vital signs.
Adenosine Cyclic is almost exclusively administered by a healthcare professional in a clinical setting. It is not a medication that patients typically self-administer at home unless they are on a long-term, stabilized immunotherapy program.
If a dose of Adenosine Cyclic is missed during an immunotherapy schedule, do not double the next dose. Contact your allergist immediately. A missed dose may require a temporary reduction in the concentration of the next injection to ensure safety and prevent a reaction.
An overdose of Adenosine Cyclic can lead to an overstimulation of the sympathetic nervous system.
> Important: Follow your healthcare provider's dosing instructions exactly. Do not adjust your dose or frequency without direct medical guidance from your specialist.
When Adenosine Cyclic is administered, particularly as part of an allergenic extract, local reactions are the most common occurrence. These typically happen within minutes to hours of administration.
> Warning: Stop taking Adenosine Cyclic and call your doctor immediately or seek emergency care if you experience any of the following symptoms of a systemic reaction.
Because Adenosine Cyclic is often used in long-term immunotherapy, clinicians monitor for cumulative effects.
While "Adenosine Cyclic" itself may not have a universal black box warning, many of the Non-Standardized Allergenic Extracts in which it is an active ingredient carry a Black Box Warning for Anaphylaxis.
Report any unusual symptoms or changes in your health to your healthcare provider immediately. Early reporting of side effects is crucial for adjusting your treatment plan safely.
Adenosine Cyclic is a potent biological mediator. It must only be used under the direct supervision of a qualified healthcare professional. Patients must be aware that while this substance is naturally occurring in the body, its administration as a drug can trigger significant physiological changes, particularly in the immune and cardiovascular systems.
Regular monitoring is required to ensure the safety and efficacy of Adenosine Cyclic therapy:
Adenosine Cyclic generally does not cause sedation. However, if a patient experiences a mild systemic reaction, dizziness, or a 'vasovagal' response (fainting) after an injection, they should not drive or operate heavy machinery until these symptoms have completely resolved.
While there is no direct chemical interaction between Adenosine Cyclic and alcohol, alcohol consumption can cause vasodilation (widening of blood vessels), which may increase the rate of absorption of an injected extract and potentially increase the risk or severity of an allergic reaction. It is advised to avoid alcohol for at least 24 hours around the time of treatment.
Stopping Adenosine Cyclic immunotherapy suddenly does not typically cause a 'withdrawal syndrome.' However, it will result in the loss of the 'desensitization' effect, and the patient's original allergy symptoms will likely return. If the drug is being used for calculi dissolution, stopping treatment may lead to the recurrence of stone formation.
> Important: Discuss all your medical conditions, including any history of heart problems or asthma, with your healthcare provider before starting Adenosine Cyclic.
Certain medications must never be used in conjunction with Adenosine Cyclic due to the risk of severe, unmanageable reactions.
For each major interaction, the mechanism typically involves either the modulation of the G-protein signaling pathway or the inhibition of the enzymes (PDEs) that clear the drug from the system. The clinical consequence is usually either a reduced ability to treat an emergency (with beta-blockers) or an exaggerated stimulant effect (with PDE inhibitors).
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, especially if you are taking heart or blood pressure medications.
Adenosine Cyclic must NEVER be used in patients with the following conditions:
Conditions requiring careful risk-benefit analysis by a specialist:
Patients who are sensitive to other adenosine-related compounds or specific nucleotides should be monitored for cross-reactivity. Furthermore, because Adenosine Cyclic is often delivered in a base of 'Non-Standardized Plant or Food Extracts,' patients with known sensitivities to related botanical families (e.g., Ragweed and Chamomile) must be treated with caution.
> Important: Your healthcare provider will evaluate your complete medical history and perform a physical exam before prescribing Adenosine Cyclic.
> Important: Special populations require individualized medical assessment and often more frequent monitoring than the general population.
Adenosine Cyclic acts as a second messenger for various extracellular signals. At the molecular level, it binds to the regulatory subunits of Protein Kinase A (PKA). This binding causes the release of the catalytic subunits of PKA, which then go on to phosphorylate specific target proteins. In the context of its use as an alpha and beta-adrenergic agonist, it mimics the intracellular state that occurs when epinephrine binds to its receptors, leading to smooth muscle relaxation (in the lungs) or increased contractility (in the heart).
| Parameter | Value |
|---|---|
| Bioavailability | <5% (Oral), ~90% (Subcutaneous) |
| Protein Binding | Low (<10%) |
| Half-life | 2–5 minutes (Systemic) |
| Tmax | 10–30 minutes (Subcutaneous) |
| Metabolism | Phosphodiesterase (PDE) enzymes |
| Excretion | Renal (as uric acid/metabolites) |
Adenosine Cyclic is classified as a cyclic nucleotide and a second messenger. Within the FDA's EPC system, it is grouped with Non-Standardized Food Allergenic Extracts, Calculi Dissolution Agents, and Adrenergic Agonists. It is chemically related to other nucleotides like Guanosine Cyclic Phosphate (cGMP).
Common questions about Guna-fem
Adenosine Cyclic, or cAMP, is primarily used as an active component in non-standardized allergenic extracts for the diagnosis and treatment of allergies. It also serves as a calculi dissolution agent to help manage urinary stones and is used in specialized anti-coagulation protocols. In a diagnostic setting, it helps doctors evaluate how well a patient's cells respond to specific hormonal signals. Because it is a fundamental biological 'second messenger,' its uses are diverse and often involve complex metabolic regulation. Always consult your specialist to understand why this specific agent is being used in your care plan.
The most frequent side effects are localized to the site of administration, typically manifesting as redness, swelling, and itching. Some patients may also experience mild systemic symptoms such as a headache, nausea, or a slight increase in heart rate shortly after the injection. These reactions are usually temporary and resolve within 24 to 48 hours. However, because it is often part of an allergenic extract, there is a risk of more significant allergic symptoms. If you notice hives, wheezing, or significant swelling away from the injection site, you must notify your healthcare provider immediately.
It is generally recommended to avoid alcohol for at least 24 hours before and after receiving an Adenosine Cyclic injection. Alcohol acts as a vasodilator, which can increase the speed at which the medication enters your bloodstream, potentially raising the risk of a systemic allergic reaction. Additionally, alcohol can mask the early symptoms of a reaction, such as dizziness or flushing, making it harder for you or your doctor to identify a problem. For your safety, it is best to remain sober during the window of administration and observation. Discuss your lifestyle habits with your doctor to ensure the safest treatment experience.
Adenosine Cyclic is typically used with extreme caution during pregnancy, and starting new therapy is generally avoided. While the molecule itself is naturally present in the body, the risk of a severe allergic reaction (anaphylaxis) from the injection poses a significant threat to the fetus by potentially cutting off its oxygen supply. If a woman is already on a stable maintenance dose of immunotherapy, her doctor may choose to continue it, but they will rarely increase the dose. A thorough risk-benefit analysis with an allergist is required for any pregnant patient. Always inform your doctor immediately if you become pregnant during treatment.
The intracellular signaling effects of Adenosine Cyclic begin almost immediately, within seconds of the molecule reaching the cell. However, when used for long-term goals like allergy desensitization, it can take several months of regular treatment to see a clinical improvement in symptoms. The 'build-up' phase of immunotherapy typically lasts 3 to 6 months, followed by a maintenance phase that can last several years. For diagnostic tests, the results are usually measured within minutes to hours of administration. Patience is key, as the immune system requires time to safely adapt to the treatment.
Yes, you can stop taking Adenosine Cyclic without experiencing physical withdrawal symptoms like those seen with opioids or benzodiazepines. However, stopping immunotherapy or calculi dissolution treatment will cause the underlying condition to return to its previous state. In the case of allergies, your sensitivity to triggers will likely return to its original level. If you are using it for stone prevention, new stones may begin to form again. You should always discuss your decision to stop treatment with your healthcare provider to ensure there are no alternative therapies you should consider first.
If you miss a scheduled dose of Adenosine Cyclic, especially for allergy immunotherapy, you should contact your doctor's office as soon as possible to reschedule. Do not attempt to 'make up' the dose by taking more later or by taking a dose at home. Depending on how much time has passed since your last injection, your doctor may need to temporarily reduce the concentration of your next dose to prevent an adverse reaction. Consistency is vital for the success of the treatment, so try to keep your appointments as scheduled. Your healthcare team will provide a specific protocol for missed appointments.
There is currently no clinical evidence to suggest that Adenosine Cyclic causes weight gain. In fact, because cAMP is involved in the process of lipolysis (the breakdown of fats) and the mobilization of glucose, it is more closely associated with energy expenditure than with fat storage. Most side effects are related to the immune response or cardiovascular stimulation rather than metabolic changes that lead to weight gain. If you experience unexpected weight changes while on this medication, it is likely due to other factors or medications. Consult your doctor to investigate any significant changes in your weight or appetite.
Adenosine Cyclic has several significant drug interactions, particularly with heart and blood pressure medications. It should never be taken with non-selective beta-blockers, as this can make allergic reactions much harder to treat. It also interacts with phosphodiesterase inhibitors like theophylline, which can lead to an unsafe buildup of cAMP in your system. Because of these risks, you must provide your healthcare provider with a complete list of all prescription drugs, over-the-counter medicines, and herbal supplements you are using. Your doctor will carefully screen these for any potential conflicts before starting your treatment.
Adenosine Cyclic is a basic biological compound, but its pharmaceutical preparations are usually specialized products like specific allergenic extracts or diagnostic kits. While 'generic' versions of some extracts exist, they are not always interchangeable because the concentrations and 'non-standardized' nature of the extracts can vary between manufacturers. Your doctor will typically prescribe a specific brand or preparation that they have experience with. In the United States, these are regulated as biological products rather than simple generic drugs. Always use the specific product recommended by your specialist to ensure consistent results.
Other drugs with the same active ingredient (Adenosine Cyclic)