Loading...
Loading...
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Brand Name
Jaysuing Hyaluronic Acid Moisturizing Sunscreen
Generic Name
Titanium Dioxide
Active Ingredient
Centella Asiatica LeafCategory
Calcium [EPC]
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| .006 mg/30mg | LIQUID | TOPICAL | 85060-013 |
Detailed information about Jaysuing Hyaluronic Acid Moisturizing Sunscreen
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Jaysuing Hyaluronic Acid Moisturizing Sunscreen, you must consult a qualified healthcare professional.
Centella Asiatica Leaf is a botanical extract classified as a Non-Standardized Plant Allergenic Extract, often utilized for its properties in wound healing and venous insufficiency management.
The dosage of Centella Asiatica Leaf varies significantly depending on the condition being treated and the specific formulation used. For Chronic Venous Insufficiency (CVI), clinical trials have typically utilized standardized extracts (such as TTFCA - Total Triterpenoid Fraction of Centella Asiatica) at a dosage range of 60 mg to 180 mg per day, usually divided into two or three doses. Higher doses toward the 180 mg mark are often reserved for more severe cases of venous hypertension or microangiopathy.
For Wound Healing, topical preparations containing 1% Centella asiatica extract are generally applied to the affected area two to three times daily. If oral supplementation is used as an adjunct for skin health, a dose of 60 mg to 120 mg daily is common. For the management of Anxiety or Cognitive Support, although not FDA-approved for these specific indications, doses used in clinical research have ranged from 500 mg to 750 mg of raw leaf powder twice daily, which equates to a much lower concentration of active triterpenoids compared to standardized extracts.
The safety and efficacy of Centella Asiatica Leaf in pediatric populations have not been established through rigorous clinical trials. Consequently, Centella Asiatica Leaf is not recommended for use in children under the age of 18 unless specifically directed by a pediatric specialist. In cases where it is used for allergenic testing, the procedure must be performed by a board-certified allergist who can manage potential anaphylactic reactions in children.
Specific guidelines for dosage adjustment in patients with renal (kidney) impairment are currently unavailable. However, because the metabolites are primarily excreted through the kidneys, healthcare providers should exercise caution. Patients with a Glomerular Filtration Rate (GFR) below 30 mL/min should be monitored closely for signs of accumulation or toxicity.
Centella Asiatica Leaf has been associated with rare cases of hepatotoxicity (liver damage). Therefore, it is contraindicated in patients with active liver disease. In patients with a history of liver dysfunction, a lower starting dose and frequent monitoring of liver function tests (LFTs) are mandatory.
Geriatric patients may be more sensitive to the effects of Centella Asiatica Leaf, particularly its potential for sedation or interactions with other medications. Starting at the lower end of the adult dosing range (e.g., 60 mg daily) is advisable, with gradual titration based on tolerance and clinical response.
If you miss a dose of Centella Asiatica Leaf, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up, as this increases the risk of side effects.
Signs of an overdose of Centella Asiatica Leaf may include severe drowsiness, extreme dizziness, or significant gastrointestinal distress. In cases of massive ingestion, there is a theoretical risk of hepatotoxicity. If an overdose is suspected, contact your local poison control center or seek emergency medical attention immediately. Treatment is generally supportive, focusing on gastric decontamination and symptom management.
> Important: Follow your healthcare provider's dosing instructions exactly. Do not adjust your dose or stop taking this medication without first consulting your medical team.
While Centella Asiatica Leaf is generally well-tolerated, some patients may experience mild side effects. The most frequently reported issues include:
> Warning: Stop taking Centella Asiatica Leaf and call your doctor immediately if you experience any of the following:
Prolonged use of Centella Asiatica Leaf (exceeding 6 to 12 months) has not been extensively studied. Potential concerns with long-term use include:
At present, there are no FDA black box warnings for Centella Asiatica Leaf. However, because it is often sold as a dietary supplement or a non-standardized extract, the level of regulatory oversight is different from that of synthetic pharmaceuticals. Patients should remain vigilant and only use products that have been verified for purity and potency by third-party organizations.
Report any unusual or persistent symptoms to your healthcare provider. Your feedback is essential for monitoring the post-market safety of botanical extracts.
Centella Asiatica Leaf is a potent botanical extract that must be used with caution. It is not a 'simple herb' but a complex pharmacological agent that can affect multiple organ systems. Patients should be aware that 'natural' does not always mean 'safe.' It is crucial to source Centella Asiatica Leaf from reputable manufacturers to avoid contamination with heavy metals (like lead or arsenic), which are sometimes found in low-quality botanical products.
No FDA black box warnings for Centella Asiatica Leaf. However, clinicians often treat the risk of hepatotoxicity with the same level of caution as a boxed warning, especially in patients with pre-existing liver conditions.
If you are taking Centella Asiatica Leaf for an extended period (longer than 6 weeks), your healthcare provider may require the following monitoring:
Centella Asiatica Leaf can cause drowsiness and dizziness. You should not drive, operate heavy machinery, or engage in hazardous activities until you know how this medication affects you. The risk of impairment is significantly increased if the extract is taken with alcohol or other sedating drugs.
Alcohol should be avoided or strictly limited while taking Centella Asiatica Leaf. Alcohol increases the risk of liver damage and can compound the sedative effects of the extract, leading to dangerous levels of respiratory or CNS depression.
While Centella Asiatica Leaf is not known to cause a traditional withdrawal syndrome, it is best to taper the dose gradually if you have been taking high doses for several months. Abruptly stopping may lead to a return of symptoms (e.g., leg swelling or anxiety). Always discuss a discontinuation plan with your doctor.
> Important: Discuss all your medical conditions, including any history of liver disease or skin cancer, with your healthcare provider before starting Centella Asiatica Leaf.
For each interaction, the mechanism usually involves either pharmacodynamic synergy (where two drugs have similar effects that add up) or metabolic competition in the liver. Management usually involves dose adjustment or choosing an alternative therapy.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, including those purchased without a prescription.
Centella Asiatica Leaf must NEVER be used in the following circumstances:
Healthcare providers must perform a careful risk-benefit analysis in the following cases:
Patients who are allergic to other members of the Apiaceae (Umbelliferae) family are at a high risk of cross-sensitivity. If you have ever had a reaction to coriander, caraway, or cumin, you should undergo a supervised patch test before using Centella Asiatica Leaf products.
> Important: Your healthcare provider will evaluate your complete medical history, including any history of liver issues or allergies, before prescribing or recommending Centella Asiatica Leaf.
Centella Asiatica Leaf is generally classified as Category C (or avoided entirely). There is insufficient evidence from well-controlled human studies to establish safety during pregnancy. Animal studies have suggested potential anti-fertility effects and the possibility of uterine stimulation. Because of the risk of miscarriage or developmental issues, pregnant women are strongly advised to avoid Centella Asiatica Leaf in both oral and topical forms. If you become pregnant while taking this medication, notify your healthcare provider immediately.
It is not known whether the active triterpenoids of Centella Asiatica Leaf pass into human breast milk. Because many botanical constituents can affect a nursing infant's developing liver or nervous system, the use of Centella Asiatica Leaf is generally not recommended for breastfeeding mothers. If use is deemed medically necessary, the infant should be monitored closely for signs of sedation, GI distress, or skin rashes.
Centella Asiatica Leaf is not approved for use in children under 18 years of age. The primary concern in pediatric populations is the lack of data regarding its effects on growth and hormonal development. In the rare instance that it is used for allergenic testing in children, it must be administered by a specialist in a clinical setting equipped for emergency resuscitation.
Elderly patients (65 years and older) should use Centella Asiatica Leaf with extreme caution. This population is at a higher risk for:
In patients with impaired kidney function, the clearance of Centella metabolites may be reduced. While specific dose-adjustment tables are not available, a reduction in frequency or dose is often recommended for patients with a GFR < 60 mL/min. Dialysis patients should avoid this extract as its clearance via hemodialysis has not been studied.
Centella Asiatica Leaf is contraindicated in patients with significant hepatic impairment (Child-Pugh Class B or C). In patients with mild impairment (Child-Pugh Class A), the risk of progressing to more severe liver injury is high, and therefore, alternative therapies for venous insufficiency or wound healing should be prioritized.
> Important: Special populations require individualized medical assessment and frequent monitoring by a qualified healthcare professional.
Centella Asiatica Leaf acts through several sophisticated molecular pathways. Its primary active constituents, the triterpenes asiaticoside and madecassoside, function as agonists of the TGF-β/Smad pathway. By binding to specific receptors on fibroblasts, these compounds stimulate the phosphorylation of Smad2 and Smad3, which then translocate to the nucleus to induce the transcription of genes responsible for Type I Collagen synthesis.
Additionally, the extract acts as a Calcium [EPC] modulator. It influences the calcium-dependent nitric oxide (NO) signaling in vascular endothelial cells, which helps to stabilize the basement membrane of capillaries and reduce the 'leakiness' associated with venous hypertension. Its 'Catecholamine [EPC]' designation refers to its ability to modulate the activity of enzymes like glutamic acid decarboxylase (GAD), which influences the balance between excitatory and inhibitory neurotransmitters in the brain.
The pharmacodynamic effects of Centella Asiatica Leaf are characterized by a slow onset and a cumulative therapeutic effect. In wound healing, the increase in tensile strength of the tissue is usually observed within 7 to 14 days of continuous application. For venous insufficiency, the reduction in edema and improvement in blood flow typically require 4 to 8 weeks of oral therapy. Tolerance to the therapeutic effects has not been widely reported, but the risk of skin sensitization increases with the duration of topical use.
| Parameter | Value |
|---|---|
| Bioavailability | 15-25% (estimated for aglycones) |
| Protein Binding | High (>80%, theoretical) |
| Half-life | 2-4 hours (Asiatic Acid) |
| Tmax | 1-2 hours |
| Metabolism | Hepatic (CYP-mediated and Glucuronidation) |
| Excretion | Renal (approx. 70%), Fecal (approx. 30%) |
Centella Asiatica Leaf is classified as a Botanical/Allergenic Extract. Within the therapeutic hierarchy, it is often grouped with 'Vasoactive Agents' or 'Vulnerary Agents' (wound healers). It shares some pharmacological similarities with other triterpene-rich plants like Aesculus hippocastanum (Horse Chestnut), although its specific Smad-pathway activation is unique.
Common questions about Jaysuing Hyaluronic Acid Moisturizing Sunscreen
Centella Asiatica Leaf is primarily used in clinical settings to treat chronic venous insufficiency, a condition where blood pools in the legs, and to promote the healing of wounds and scars. It works by strengthening the walls of blood vessels and stimulating the production of collagen in the skin. Some healthcare providers also use it off-label to help manage symptoms of anxiety or to support cognitive function. However, it is most recognized for its vascular and dermatological benefits. Always consult your doctor to see if it is appropriate for your specific health needs.
The most common side effects of Centella Asiatica Leaf include gastrointestinal issues such as nausea, stomach cramps, and digestive discomfort. Some individuals may also experience dizziness or a mild sedative effect, leading to drowsiness. When applied topically to the skin, it can occasionally cause itching, redness, or a burning sensation known as contact dermatitis. These side effects are generally mild and often resolve on their own as the body adjusts to the medication. If side effects persist or become bothersome, you should contact your healthcare provider for guidance.
It is strongly recommended that you avoid or strictly limit alcohol consumption while taking Centella Asiatica Leaf. Both alcohol and Centella can put stress on the liver, and combining them increases the risk of serious liver damage or hepatotoxicity. Additionally, Centella has mild sedative properties that can be significantly intensified by alcohol, leading to extreme drowsiness or impaired coordination. This combination can make activities like driving or operating machinery very dangerous. Always discuss your alcohol intake with your doctor before starting any botanical extract.
No, Centella Asiatica Leaf is generally considered unsafe for use during pregnancy. Traditional evidence suggests that the plant may have emmenagogue effects, meaning it could stimulate menstrual flow or uterine contractions, potentially leading to a miscarriage. There is also a significant lack of modern clinical data to prove its safety for the developing fetus. Due to these potential risks, healthcare providers advise pregnant women to avoid both oral and topical forms of the herb. If you are planning to become pregnant, you should stop taking Centella and consult your physician.
The time it takes for Centella Asiatica Leaf to work depends on the condition being treated. For wound healing, you may see improvements in skin repair and tissue strength within 1 to 2 weeks of consistent application. However, for chronic conditions like venous insufficiency, it typically takes longer, often requiring 4 to 8 weeks of daily use before symptoms like leg swelling and pain begin to diminish. It is important to follow the prescribed dosing schedule and not to stop the treatment prematurely if results are not immediate. Clinical benefits are often cumulative over several months.
While Centella Asiatica Leaf is not known to be addictive or cause a severe withdrawal syndrome, you should not stop taking it suddenly without consulting your doctor, especially if you have been using it long-term. Abrupt discontinuation may cause a 'rebound' of your symptoms, such as increased leg swelling or a return of anxiety. Your healthcare provider may recommend a gradual tapering of the dose to allow your body to adjust. Always follow a professional medical plan when ending any long-term pharmacological treatment. This ensures that your condition remains stable during the transition.
If you miss a dose of Centella Asiatica Leaf, you should take it as soon as you remember. However, if it is nearly time for your next scheduled dose, it is better to skip the missed dose and continue with your regular routine. You should never take two doses at once to make up for a missed one, as this can increase your risk of experiencing side effects like dizziness or nausea. Keeping a consistent schedule helps maintain steady levels of the active triterpenoids in your system. If you frequently miss doses, consider using a pill reminder or alarm.
There is currently no clinical evidence to suggest that Centella Asiatica Leaf causes weight gain. In fact, because it helps reduce edema (fluid retention) in patients with venous insufficiency, some individuals might notice a slight decrease in 'water weight' or swelling in the lower limbs. It does not appear to affect appetite or metabolic rate in a way that would lead to an increase in body fat. If you experience sudden or unexplained weight gain while taking this medication, it may be due to another underlying condition or a different medication, and you should discuss it with your doctor.
Centella Asiatica Leaf can interact with several types of medications, so caution is necessary. It should not be taken with other drugs that can harm the liver, such as certain cholesterol medications or high doses of acetaminophen. It may also increase the effects of sedatives, sleep aids, and anti-anxiety drugs, leading to excessive sleepiness. Additionally, it might lower blood sugar, which can be dangerous if you are already taking diabetes medications. Always provide your healthcare provider with a complete list of all prescriptions, over-the-counter drugs, and supplements you are using to avoid dangerous interactions.
Centella Asiatica Leaf is a botanical product, so it does not have a 'generic' version in the same way that synthetic drugs like ibuprofen do. Instead, it is available under many different brand names and as various standardized extracts. When looking for a high-quality product, you should search for those that specify the amount of active triterpenoids (like asiaticoside). While many over-the-counter versions exist, clinical-grade extracts used in medical studies are often more potent and purified. Your pharmacist or doctor can help you select a reputable and effective formulation.
Other drugs with the same active ingredient (Centella Asiatica Leaf)