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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Brand Name
Methitest
Generic Name
Methyltestosterone
Active Ingredient
MethyltestosteroneCategory
Androgen [EPC]
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 10 mg/1 | TABLET | ORAL | 0115-7037 |
Detailed information about Methitest
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Methitest, you must consult a qualified healthcare professional.
Methyltestosterone is an orally active anabolic-androgenic steroid (AAS) used to treat testosterone deficiency in men and manage advanced breast cancer in women. It belongs to the androgen drug class and acts as an androgen receptor agonist.
Dosage for Methyltestosterone must be highly individualized based on the patient's age, sex, diagnosis, and clinical response. Your healthcare provider will typically start with the lowest effective dose and adjust as necessary.
Methyltestosterone is not generally recommended for use in children except for the specific indication of delayed puberty in males. It is not approved for use in female children. When used in males for delayed puberty, the dose must be strictly controlled by a pediatric endocrinologist. Overdosage or prolonged use in children can lead to premature epiphyseal closure (stopping of bone growth) and precocious (early) sexual development.
There are no specific quantitative guidelines for dosage adjustment in patients with renal (kidney) impairment. However, because androgens can cause fluid retention and edema (swelling), Methyltestosterone should be used with extreme caution in patients with significant kidney disease. Your doctor may choose to monitor your kidney function and electrolyte levels more frequently.
Methyltestosterone is contraindicated (should not be used) in patients with severe hepatic (liver) impairment. Because the drug is a 17-alpha-alkylated steroid, it places a significant metabolic burden on the liver. In patients with mild to moderate liver dysfunction, the drug should be used with extreme caution, and liver function tests (LFTs) must be performed regularly. If LFTs become elevated, the drug should be discontinued immediately.
Geriatric patients (65 and older) may be at an increased risk of developing prostatic hypertrophy (enlarged prostate) or prostatic carcinoma while taking androgens. Additionally, older adults are more susceptible to fluid retention, which can exacerbate underlying heart failure. Healthcare providers often prescribe a lower starting dose for elderly patients and monitor prostate-specific antigen (PSA) levels closely.
If you miss a dose of Methyltestosterone, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular dosing schedule. Do not 'double up' or take two doses at once to make up for a missed one, as this increases the risk of side effects.
Acute overdose of Methyltestosterone is unlikely to be life-threatening, but chronic overuse (often associated with misuse for athletic performance) can lead to serious cardiovascular and psychiatric issues. Signs of an acute overdose might include nausea or gastrointestinal distress. In the event of a suspected large-scale ingestion, contact your local poison control center or seek emergency medical attention immediately. Treatment is generally supportive.
> Important: Follow your healthcare provider's dosing instructions exactly. Do not adjust your dose or stop taking the medication without medical guidance, as this can lead to hormonal imbalances or a return of your symptoms.
Many patients taking Methyltestosterone may experience mild to moderate side effects as their body adjusts to the hormone. These often include:
> Warning: Stop taking Methyltestosterone and call your doctor immediately if you experience any of these serious symptoms:
Prolonged use of Methyltestosterone is associated with several chronic health risks:
Methyltestosterone carries a significant warning regarding Hepatotoxicity. Clinical data indicates that 17-alpha-alkylated androgens can cause serious, sometimes fatal, liver injuries. This includes cholestatic hepatitis, jaundice, and in rare cases, hepatocellular carcinoma. Peliosis hepatis, a condition where blood-filled cysts form in the liver or spleen, has also been reported. These cysts can sometimes rupture, leading to internal bleeding. Your healthcare provider will perform regular liver function tests to monitor for these risks. If you notice any signs of liver dysfunction, such as yellowing of the skin or eyes, notify your medical team immediately.
Report any unusual symptoms to your healthcare provider. Monitoring and early detection are key to managing the side effect profile of this medication.
Methyltestosterone is a potent hormonal medication that must be used only under strict medical supervision. It is classified as a Schedule III controlled substance in the United States due to its potential for misuse and abuse. Patients should never share this medication with others, even if they have similar symptoms. Before starting treatment, it is essential to disclose your full medical history, especially any history of cancer, heart disease, or liver problems.
Hepatotoxicity and Peliosis Hepatis: Methyltestosterone is a 17-alpha-alkylated androgen. This class of drugs is associated with serious hepatic (liver) adverse effects. Peliosis hepatis, a condition in which blood-filled cysts replace normal liver or splenic tissue, has been reported in patients receiving androgen therapy. These cysts can lead to liver failure or intra-abdominal hemorrhage. Additionally, liver tumors (adenomas and carcinomas) have been linked to long-term, high-dose androgen use. Cholestatic hepatitis and jaundice may also occur. If clinical signs of liver damage appear, the drug must be discontinued immediately.
To ensure safety while taking Methyltestosterone, your healthcare provider will require periodic lab tests:
Methyltestosterone does not typically cause drowsiness or cognitive impairment that would interfere with driving. However, if you experience significant mood changes, dizziness, or headaches, you should avoid operating heavy machinery until you know how the medication affects you.
Alcohol consumption should be strictly limited or avoided while taking Methyltestosterone. Both alcohol and Methyltestosterone are processed by the liver. Combining them significantly increases the risk of hepatotoxicity and liver strain. Furthermore, alcohol can interfere with hormone levels and exacerbate fluid retention.
Do not stop taking Methyltestosterone abruptly without consulting your doctor. While it does not typically cause a 'withdrawal' syndrome in the traditional sense, sudden discontinuation can cause a rapid drop in hormone levels, leading to fatigue, depression, and a return of the original symptoms. Your doctor may suggest a gradual reduction in dose if you need to stop the medication.
> Important: Discuss all your medical conditions, including any history of blood clots, high calcium, or kidney disease, with your healthcare provider before starting Methyltestosterone.
Certain medications should never be taken with Methyltestosterone due to the risk of life-threatening interactions:
Methyltestosterone can interfere with several laboratory tests, potentially leading to inaccurate results:
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, including over-the-counter pain relievers and vitamins.
Methyltestosterone must NEVER be used in patients with the following conditions, as the risks far outweigh any potential benefits:
In these conditions, your healthcare provider will perform a careful risk-benefit analysis before prescribing Methyltestosterone:
Patients who have had allergic reactions to other synthetic androgens or anabolic steroids (such as oxandrolone, danazol, or testosterone cypionate) may be at an increased risk of a cross-allergic reaction to Methyltestosterone. Always inform your pharmacist if you have had a reaction to any hormonal treatment in the past.
> Important: Your healthcare provider will evaluate your complete medical history, including any family history of early-onset heart disease or cancer, before prescribing Methyltestosterone.
Methyltestosterone is strictly contraindicated during pregnancy. It is classified as FDA Category X. Exposure to androgens during pregnancy, especially during the first trimester, leads to the virilization of the external genitalia of the female fetus. This can include clitoral hypertrophy, labial fusion, and the development of a urogenital sinus. If a patient becomes pregnant while taking this medication, she must be informed of the severe potential hazard to the fetus and the medication must be stopped immediately.
It is not known whether Methyltestosterone is excreted in human milk. However, because many drugs are excreted in milk and because of the potential for serious adverse reactions in nursing infants (such as premature puberty or growth issues), a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. Most healthcare providers advise against breastfeeding while on androgen therapy.
In children, Methyltestosterone should be used with extreme caution and only for the treatment of delayed puberty in males. The primary concern is the acceleration of bone maturation without a compensatory gain in linear growth. This can result in 'premature epiphyseal closure' and a permanent reduction in adult height. Pediatric patients must have their bone age monitored via hand and wrist X-rays every six months. It is not recommended for use in children for any other purpose.
Clinical studies of Methyltestosterone did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. However, geriatric patients are known to be at higher risk for:
While Methyltestosterone is not primarily cleared by the kidneys, its tendency to cause sodium and water retention makes it risky for patients with renal impairment. Patients with a glomerular filtration rate (GFR) below 30 mL/min should be monitored very closely for signs of fluid overload. There are no established dose-reduction protocols based on GFR, but clinical judgment is required.
Methyltestosterone is essentially contraindicated in patients with significant hepatic impairment. For those with mild impairment (Child-Pugh Class A), the drug should be used at the lowest possible dose with weekly or bi-weekly liver function monitoring. The 17-alpha-alkylated nature of the drug makes it one of the more hepatotoxic androgens available.
> Important: Special populations require individualized medical assessment and more frequent laboratory monitoring to ensure safety.
Methyltestosterone is a synthetic derivative of testosterone. Its primary molecular mechanism involves binding to the androgen receptor (AR). Because it is 17-alpha-methylated, it resists hepatic metabolism, allowing for oral efficacy. Once bound to the AR, it acts as a transcription factor, moving to the nucleus and binding to DNA. This regulates the expression of genes involved in the development of male primary and secondary sexual characteristics. It also exerts anabolic effects, such as increasing nitrogen retention and protein synthesis in skeletal muscle.
The pharmacodynamic effects of Methyltestosterone are dose-dependent. Low doses provide replacement levels of androgenic activity, while higher doses (used in cancer treatment) can suppress the pituitary gland's production of gonadotropins through a negative feedback loop. The onset of effect for muscle or libido changes may take several weeks, while the palliative effects in breast cancer may take up to three months to become fully apparent.
| Parameter | Value |
|---|---|
| Bioavailability | Variable (Orally Active) |
| Protein Binding | ~98% (primarily to SHBG and Albumin) |
| Half-life | 2.5 - 3.5 hours |
| Tmax | 1.5 - 2.5 hours |
| Metabolism | Hepatic (17-alpha-alkylation prevents rapid 17-OH oxidation) |
| Excretion | Renal (90% as metabolites), Fecal (small amounts) |
Methyltestosterone is classified as an Androgen [EPC] and an Androgen Receptor Agonist [MoA]. It is a Schedule III controlled substance under the Controlled Substances Act. Related medications include Testosterone (injectable/topical), Oxandrolone (oral), and Fluoxymesterone (oral).
Common questions about Methitest
Methyltestosterone is primarily used as hormone replacement therapy in men who do not produce enough natural testosterone due to medical conditions like hypogonadism. It is also used to treat delayed puberty in adolescent boys to help stimulate the development of secondary male characteristics. In women, it is sometimes prescribed as a palliative treatment for advanced, inoperable breast cancer that has spread to other parts of the body. Because it is an oral medication, it is often chosen when patients prefer tablets over injections or skin patches. However, its use is strictly limited to these FDA-approved indications due to its potential for serious side effects. Your doctor will determine if this specific androgen is the best choice for your clinical needs.
The most common side effects of Methyltestosterone include acne, oily skin, and fluid retention, which can cause swelling in the hands or feet. Men may experience more frequent erections or breast tissue enlargement (gynecomastia), while women may notice signs of virilization such as hair growth on the face or a deepening of the voice. Some patients also report nausea, headaches, or changes in their sexual desire shortly after starting the medication. Because it can affect mood, irritability or anxiety are also frequently reported. Most of these side effects are dose-related and may improve if your doctor adjusts your prescription. Always report new or worsening symptoms to your healthcare provider immediately.
It is strongly recommended that you avoid or strictly limit alcohol consumption while taking Methyltestosterone. Both alcohol and this medication are processed by the liver, and taking them together can significantly increase the risk of liver strain or hepatotoxicity. Methyltestosterone is a 17-alpha-alkylated steroid, which is already known to be taxing on the liver; adding alcohol can exacerbate this risk. Furthermore, alcohol can worsen fluid retention and interfere with the hormonal balance the medication is trying to achieve. Chronic alcohol use can also lower natural testosterone levels, counteracting the benefits of the treatment. For your safety, discuss your alcohol intake habits with your doctor before starting this therapy.
No, Methyltestosterone is absolutely not safe during pregnancy and is classified as FDA Pregnancy Category X. If taken by a pregnant woman, it can cause severe and permanent birth defects, specifically the virilization of a female fetus. This means a female baby may develop male physical characteristics due to the high levels of synthetic androgen in the mother's system. Women of childbearing age should use effective contraception while taking this drug and stop it immediately if pregnancy is suspected. It is also generally avoided during breastfeeding because its effects on nursing infants are not well-documented but potentially harmful. Always inform your doctor if you are planning to become pregnant before starting any hormone therapy.
The time it takes for Methyltestosterone to show results depends on the condition being treated and the individual's response. For symptoms of low testosterone, such as low energy or decreased libido, some patients may notice improvements within 3 to 6 weeks of consistent use. However, changes in muscle mass or bone density typically take several months of therapy to become apparent. In cases of delayed puberty, the treatment is often monitored over 4 to 6 months to ensure proper development. For women being treated for breast cancer, it may take up to 3 months of therapy to determine if the drug is effectively slowing the progression of the disease. Your doctor will schedule regular follow-ups to assess your progress.
You should not stop taking Methyltestosterone suddenly without first consulting your healthcare provider. While it is not an addictive drug in the traditional sense, stopping it abruptly can cause your hormone levels to crash, leading to significant fatigue, depression, and a return of the symptoms you were originally treating. If you have been taking the medication for a long time, your body may have slowed its own natural hormone production, and it needs time to adjust. Your doctor will typically provide a schedule to gradually taper off the dose to minimize these effects. If you are experiencing serious side effects, your doctor may advise an immediate stop, but this should only be done under medical supervision.
If you miss a dose of Methyltestosterone, you should take it as soon as you remember. However, if it is almost time for your next scheduled dose, you should skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time to 'make up' for the one you missed, as this can increase the risk of side effects like nausea or high blood pressure. Keeping your hormone levels as stable as possible is important for the medication's effectiveness, so try to take it at the same time every day. Using a pillbox or a phone reminder can help you stay on track with your treatment plan.
Methyltestosterone can cause weight gain, but the type of weight gain varies. One common cause is fluid retention (edema), where the body holds onto extra water and sodium, leading to a 'puffy' appearance and a quick increase in scale weight. Another cause is the anabolic effect of the drug, which can increase muscle mass over time when combined with proper nutrition and exercise. However, some patients may also experience an increase in appetite, which could lead to an increase in body fat if not managed. If you notice sudden or excessive weight gain, especially if accompanied by swelling in the legs or shortness of breath, you should contact your doctor, as it could be a sign of heart or kidney strain.
Methyltestosterone has several significant drug interactions that your doctor must monitor. It can increase the effects of blood thinners like warfarin, which significantly raises the risk of bleeding. It may also lower blood sugar levels, meaning patients with diabetes might need to adjust their insulin or oral medication doses. Additionally, taking it with corticosteroids can increase the risk of severe swelling and fluid retention. You should provide your doctor with a complete list of all prescriptions, over-the-counter drugs, and herbal supplements you are taking. This allows your healthcare team to adjust your treatment plan to avoid dangerous interactions and ensure the medication works safely.
Yes, Methyltestosterone is available as a generic medication, which is typically more cost-effective than brand-name versions. Generic versions are required by the FDA to have the same active ingredient, strength, dosage form, and route of administration as the brand-name drug. While the brand name 'Metandren' or 'Android' may be less common today, the generic tablets are widely produced by various pharmaceutical manufacturers. You should check with your pharmacist to see which version is covered by your insurance plan. Regardless of whether you take the brand or generic version, the safety precautions and monitoring requirements remain the same.
Other drugs with the same active ingredient (Methyltestosterone)