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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Nausea/morning Sickness Drops
Brand Name
Nausea/morning Sickness Drops
Generic Name
Nausea/morning Sickness Drops
Active Ingredient
Anamirta Cocculus FruitCategory
Non-Standardized Plant Allergenic Extract [EPC]
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 5 [hp_X]/59mL | LIQUID | ORAL | 63083-2079 |
Detailed information about Nausea/morning Sickness Drops
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Nausea/morning Sickness Drops, you must consult a qualified healthcare professional.
Anamirta Cocculus Fruit is a specialized pharmaceutical agent used primarily as a non-standardized allergenic extract and a phosphate binder. It plays a critical role in managing hyperphosphatemia and diagnostic allergy testing under strict medical supervision.
The dosage of Anamirta Cocculus Fruit must be strictly individualized based on the patient's clinical needs, serum phosphate levels, or the requirements of diagnostic testing. For its primary indication as a Phosphate Binder, the standard adult starting dose typically ranges from 200 mg to 500 mg orally, taken three times daily with meals. Healthcare providers will monitor serum phosphorus levels every 2–4 weeks and titrate the dose accordingly. The maximum daily dose should not exceed 3,000 mg unless specifically directed by a nephrologist (kidney specialist).
In the context of Allergenic Extract testing, the dosage is measured in protein nitrogen units (PNU) or weight/volume (w/v) dilutions. A common concentration for skin prick testing is 1:10 or 1:20 w/v. For intradermal testing, much higher dilutions (e.g., 1:1000 or 1:10,000) are used to minimize the risk of systemic reactions. These procedures must only be performed by a board-certified allergist in a facility equipped to handle anaphylaxis.
Anamirta Cocculus Fruit is generally not recommended for pediatric use in its capacity as a phosphate binder due to a lack of robust clinical trials in children. However, in specific cases of pediatric CKD, a specialist may prescribe a weight-based dose, often starting at 5–10 mg/kg per meal. For allergenic testing in children, the same concentrations used for adults are typically applied, but with increased caution regarding the volume of extract administered. Always consult a pediatric specialist before administering any form of this medication to a minor.
For patients with mild to moderate renal impairment, no specific dose adjustment is required for the phosphate binder form, as the drug acts locally in the gut. However, in end-stage renal disease (ESRD), the dose is titrated based on the severity of hyperphosphatemia rather than the degree of GFR (glomerular filtration rate) reduction. Monitoring for alkaloid accumulation is necessary if systemic absorption occurs.
Patients with significant hepatic (liver) impairment should be monitored closely. Since the liver is responsible for the metabolism of absorbed alkaloids like picrotoxin, impaired liver function may increase the risk of CNS toxicity. Dose reductions of 25-50% may be considered in patients with Child-Pugh Class C cirrhosis.
Geriatric patients should start at the lower end of the dosing spectrum (e.g., 200 mg per meal). This population is more susceptible to the CNS effects of picrotoxin and may have undiagnosed reductions in renal or hepatic clearance.
To ensure maximum efficacy and safety, follow these specific administration guidelines:
If you miss a dose of Anamirta Cocculus Fruit during a meal, take it as soon as you remember, provided the meal was finished within the last 30 minutes. If more time has passed, skip the missed dose and take your next dose with your next scheduled meal. Do not double the dose to make up for a missed one, as this increases the risk of toxicity without providing additional phosphate-binding benefits.
An overdose of Anamirta Cocculus Fruit can be life-threatening due to the picrotoxin content. Signs of overdose include:
In the event of a suspected overdose, call 911 or seek emergency medical attention immediately. Treatment typically involves supportive care, including the administration of benzodiazepines to control seizures and gastric lavage if the ingestion was recent.
> Important: Follow your healthcare provider's dosing instructions exactly. Do not adjust your dose or stop taking this medication without medical guidance, as this can lead to dangerous fluctuations in phosphate levels.
Patients taking Anamirta Cocculus Fruit most frequently report gastrointestinal disturbances, particularly when used as a phosphate binder. These effects are often dose-dependent and may include:
> Warning: Stop taking Anamirta Cocculus Fruit and call your doctor immediately if you experience any of these symptoms. These may indicate severe toxicity or a life-threatening allergic reaction.
Prolonged use of Anamirta Cocculus Fruit, especially in the context of CKD, requires careful monitoring for long-term complications:
As of 2024, there are no formal FDA black box warnings specifically for Anamirta Cocculus Fruit in its non-standardized extract form. However, healthcare providers are cautioned regarding the Seizure Risk inherent in picrotoxin-containing substances. The FDA-approved labeling for related allergenic extracts emphasizes the risk of Severe Systemic Allergic Reactions, including anaphylaxis, which must be managed in a clinical setting with available epinephrine.
Report any unusual symptoms or persistent side effects to your healthcare provider immediately. Early intervention is key to managing the complex side effect profile of this botanical pharmaceutical.
Anamirta Cocculus Fruit is a potent pharmacological agent that must be used with extreme caution. It is not a standard over-the-counter herbal supplement; rather, it is a regulated pharmaceutical substance (EPC) with significant systemic effects. Patients must be aware that the active ingredient, picrotoxin, is a powerful CNS stimulant that can cause severe neurological complications if not monitored correctly. This medication should only be used under the direct supervision of a nephrologist, allergist, or clinical pharmacologist who is familiar with its unique profile.
No FDA black box warnings for Anamirta Cocculus Fruit are currently active. However, similar products in the Non-Standardized Allergenic Extract class carry warnings regarding the potential for life-threatening anaphylaxis. Clinicians are advised to treat this substance with the same level of vigilance as other high-risk allergenic or metabolic agents.
To ensure safety, the following laboratory tests and clinical assessments are mandatory for patients on long-term therapy:
Anamirta Cocculus Fruit may cause dizziness, vertigo, or sudden changes in neurological status. Patients should avoid driving, operating heavy machinery, or engaging in hazardous activities until they are certain the medication does not impair their cognitive or motor functions. This is particularly important during the first two weeks of therapy or following a dose increase.
Alcohol should be strictly avoided while taking Anamirta Cocculus Fruit. Alcohol can lower the seizure threshold and may interact with the CNS effects of picrotoxin, increasing the risk of both sedation and paradoxical hyperexcitability. Furthermore, alcohol consumption can interfere with the management of phosphate levels in patients with kidney disease.
Do not stop taking Anamirta Cocculus Fruit abruptly, especially if being used as a phosphate binder. Sudden discontinuation can lead to a rapid rebound in serum phosphorus levels (rebound hyperphosphatemia), which can cause acute bone pain and cardiovascular stress. If the drug must be stopped, your doctor will likely taper the dose while introducing an alternative phosphate binder.
> Important: Discuss all your medical conditions, especially any history of seizures or kidney issues, with your healthcare provider before starting Anamirta Cocculus Fruit.
Certain medications must NEVER be used in combination with Anamirta Cocculus Fruit due to the risk of severe adverse events:
For each major interaction, the management strategy usually involves spacing the administration of the drugs (the "4-hour rule") or adjusting the dose based on frequent blood monitoring.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking to prevent dangerous drug-drug interactions.
Anamirta Cocculus Fruit must NEVER be used in patients with the following conditions, as the risks far outweigh any potential benefits:
In these scenarios, a careful risk-benefit analysis by a healthcare provider is required:
Patients who are allergic to other botanical extracts in the Ranunculales order may exhibit cross-sensitivity to Anamirta Cocculus Fruit. This includes certain types of barberries or moonseeds. Always inform your allergist of all known plant or food allergies before undergoing testing with this extract.
> Important: Your healthcare provider will evaluate your complete medical history, including any neurological or gastrointestinal issues, before prescribing Anamirta Cocculus Fruit.
Anamirta Cocculus Fruit is classified as FDA Pregnancy Category C (or equivalent under newer labeling rules). There are no adequate and well-controlled studies in pregnant women. Animal studies have suggested that picrotoxin can cross the placental barrier and may exert neuroexcitatory effects on the developing fetal nervous system. Its use during pregnancy is generally discouraged, especially during the first trimester when organogenesis is occurring. If hyperphosphatemia must be treated during pregnancy, healthcare providers typically prefer better-studied agents like calcium acetate or sevelamer. If Anamirta Cocculus is used, it should be at the lowest effective dose with frequent monitoring of fetal heart rate and maternal neurological status.
It is not known whether the constituents of Anamirta Cocculus Fruit, particularly picrotoxin or its metabolites, are excreted in human milk. However, many alkaloids do pass into breast milk and could potentially cause irritability, tremors, or sleep disturbances in the nursing infant. Because of the potential for serious adverse reactions in the infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
The safety and effectiveness of Anamirta Cocculus Fruit in pediatric patients have not been established for the treatment of hyperphosphatemia. Children have a developing nervous system that may be more sensitive to the GABA-antagonistic effects of the extract. In diagnostic allergy testing, it should be used with caution and only by specialists experienced in pediatric immunology. Growth parameters should be monitored if used off-label for long periods in children with CKD, as phosphate binders can impact mineral-bone metabolism.
Clinical studies of Anamirta Cocculus Fruit did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Elderly patients are at a significantly higher risk for falls if the drug causes dizziness or vertigo.
While the drug is used to treat a complication of renal impairment (hyperphosphatemia), the presence of severe renal failure (GFR < 15 mL/min) changes the monitoring requirements. In these patients, the risk of mineral imbalances (like low calcium or high magnesium) is increased. The drug itself is not cleared renally in its complexed form, but any systemically absorbed alkaloids may accumulate if renal clearance is compromised.
No formal studies have been conducted in patients with hepatic impairment. However, since the liver is the primary site for the detoxification of picrotoxin, patients with Child-Pugh Class B or C impairment should be monitored for signs of CNS toxicity. Dose adjustments are likely necessary, and alternative phosphate binders that do not contain systemic alkaloids may be preferred.
> Important: Special populations require individualized medical assessment and frequent follow-up to ensure the safe use of this complex botanical extract.
Anamirta Cocculus Fruit functions through two primary pharmacological pathways. As a Phosphate Binder, it utilizes its high affinity for inorganic phosphate ions within the acidic and neutral environments of the gastrointestinal tract. The extract contains various botanical ligands that engage in Phosphate Chelating Activity [MoA], forming non-absorbable complexes that are excreted in the feces. This reduces the total pool of phosphate available for systemic absorption, thereby lowering serum phosphorus levels.
At the molecular level, the extract also contains Picrotoxin, which consists of two compounds: picrotoxinin and picrotin. Picrotoxinin is the active component that acts as a GABA-A receptor antagonist. Unlike benzodiazepines which bind to a specific site to enhance GABA, picrotoxinin binds inside the chloride channel pore itself. By physically blocking the flow of chloride ions, it prevents the hyperpolarization of neurons, leading to increased neuronal firing. This explains the drug's role as a CNS stimulant and its potential for neurotoxicity.
The dose-response relationship for phosphate binding is linear within the therapeutic range (200-1000 mg per meal). The onset of action for phosphate binding is immediate upon contact with food in the stomach, with the duration of effect lasting as long as the substance remains in the small intestine (typically 4-6 hours). Tolerance to the phosphate-binding effect does not occur, but the body may become more sensitive to the CNS effects over time if systemic accumulation occurs.
| Parameter | Value |
|---|---|
| Bioavailability | < 5% (for phosphate-binding complex); ~30% (for picrotoxin) |
| Protein Binding | 40% - 60% (systemic alkaloids) |
| Half-life | 1.5 - 3 hours (picrotoxin) |
| Tmax | 1 - 2 hours (for absorbed components) |
| Metabolism | Hepatic (primarily CYP3A4) |
| Excretion | Fecal (>90%), Renal (<5%) |
Anamirta Cocculus Fruit is classified as a Non-Standardized Plant Allergenic Extract [EPC]. Within the therapeutic area of nephrology, it is categorized as a Phosphate Binder [EPC]. It is chemically distinct from other binders like Sevelamer (a synthetic polymer) or Calcium Acetate (a mineral salt), as it is a complex botanical extract with secondary CNS activity.
Common questions about Nausea/morning Sickness Drops
Anamirta Cocculus Fruit is primarily used as a phosphate binder to treat hyperphosphatemia in patients with chronic kidney disease. By binding to phosphate in the digestive tract, it prevents the mineral from entering the bloodstream, which helps prevent bone and heart complications. Additionally, it is used by specialists as a non-standardized allergenic extract for diagnostic allergy testing. Some traditional or homeopathic practices use highly diluted forms for motion sickness, though this is a separate clinical application. Always use this medication under strict medical supervision due to its potent active components.
The most common side effects are gastrointestinal in nature, including nausea, vomiting, abdominal cramping, and diarrhea. These symptoms usually occur because the medication is working locally in the gut to bind phosphate from your food. Some patients may also experience mild dizziness or headaches due to the drug's minor systemic effects. In allergy testing, localized redness and itching at the test site are very common. If these symptoms become severe or persistent, you should contact your healthcare provider to discuss a possible dose adjustment.
No, you should strictly avoid alcohol while taking Anamirta Cocculus Fruit. Alcohol can significantly lower your seizure threshold, which is dangerous because this medication contains picrotoxin, a substance known to stimulate the central nervous system. Combining the two increases the risk of experiencing a seizure or severe neurological agitation. Furthermore, alcohol can interfere with the management of kidney disease and phosphate levels. Always consult your doctor about your lifestyle habits when starting a new pharmaceutical extract.
Anamirta Cocculus Fruit is generally not recommended during pregnancy unless the benefits clearly outweigh the risks. It is classified as Pregnancy Category C, meaning animal studies have shown potential harm to the fetus, but human data is lacking. The active alkaloid, picrotoxin, can cross the placenta and may affect the developing nervous system of the baby. Most doctors will prefer to use better-studied phosphate binders during pregnancy. If you are pregnant or planning to become pregnant, discuss alternative treatments with your nephrologist or obstetrician.
As a phosphate binder, the medication begins working immediately upon contact with food in your stomach and intestines. However, it may take several days or weeks of consistent use before your blood tests show a significant decrease in serum phosphorus levels. Your doctor will likely check your levels every 2 to 4 weeks to determine how well the medication is working. For allergy testing, the reaction typically occurs within 15 to 30 minutes of application. It is vital to take the medication with every meal to ensure it works effectively throughout the day.
You should never stop taking Anamirta Cocculus Fruit suddenly without consulting your doctor. If you are using it to manage high phosphate levels, stopping abruptly can cause your phosphate levels to spike rapidly. This 'rebound' effect can lead to acute bone pain, severe itching, and long-term damage to your cardiovascular system. If the medication needs to be discontinued due to side effects, your healthcare provider will provide a tapering schedule or immediately switch you to a different type of phosphate binder to keep your levels stable.
If you miss a dose during a meal, take it as soon as you remember, but only if you have finished eating within the last 30 minutes. If more time has passed, skip the missed dose entirely and wait until your next scheduled meal. Do not take extra medicine or double the dose to make up for the one you missed, as this can increase the risk of picrotoxin toxicity. Since the drug needs to bind with food to be effective, taking it too long after a meal provides little benefit. Consistency is key to managing your phosphate levels.
There is no clinical evidence to suggest that Anamirta Cocculus Fruit causes significant weight gain. Most side effects are related to the digestive system or the central nervous system. However, patients with chronic kidney disease may experience weight fluctuations due to fluid retention or changes in diet. If you notice sudden or unexplained weight gain while taking this medication, it is more likely related to your underlying kidney condition or heart health. You should report any significant changes in weight or swelling to your healthcare team immediately.
Anamirta Cocculus Fruit has several significant drug interactions, particularly with medications that affect the brain or the absorption of minerals. It can interfere with the absorption of thyroid hormones, certain antibiotics, and iron supplements. Most importantly, it should not be taken with drugs that affect the GABA system, such as benzodiazepines, as it can block their effects. To prevent interactions, many doctors recommend the '4-hour rule'—taking other medications at least 4 hours before or after your phosphate binder. Always provide your doctor with a full list of your current medicines.
Anamirta Cocculus Fruit is a specialized botanical extract and is not typically available as a standard 'generic' in the way synthetic drugs like lisinopril are. It is often sold under specific brand names or as a non-standardized pharmaceutical extract. Because it is classified as a Non-Standardized Plant Allergenic Extract, different preparations may vary slightly in their potency. You should always use the specific brand or formulation prescribed by your doctor and avoid switching between different products without medical approval to ensure consistent phosphate control and safety.
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