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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Agaricus Muscarius, Coccus Cacti, Conium Maculatum, Lycopodium Clavatum, Phosphorus, Aluminium Metallicum, Antimonium Crudum, Argentum Metallicum, Arsenicum Album, Aurum Metallicum, Baryta Carbonica, Beryllium Metallicum, Bismuthum Metallicum, Boron, Bromium, Cadmium Metallicum Cerium Metallicum, Cesium Chloride, Chromium, Cobaltum Metallicum, Cuprum Metallicum, Dysprosium Metallicum, Erbium Metallicum, Europium Metallicum, Ferrum Metallicum, Gadolinium Metallicum, Germanium Sesquioxide, Holmium Metallicum,
Brand Name
Neurotox
Generic Name
Agaricus Muscarius, Coccus Cacti, Conium Maculatum, Lycopodium Clavatum, Phosphorus, Aluminium Metallicum, Antimonium Crudum, Argentum Metallicum, Arsenicum Album, Aurum Metallicum, Baryta Carbonica, Beryllium Metallicum, Bismuthum Metallicum, Boron, Bromium, Cadmium Metallicum Cerium Metallicum, Cesium Chloride, Chromium, Cobaltum Metallicum, Cuprum Metallicum, Dysprosium Metallicum, Erbium Metallicum, Europium Metallicum, Ferrum Metallicum, Gadolinium Metallicum, Germanium Sesquioxide, Holmium Metallicum,
Active Ingredient
AluminumCategory
Standardized Chemical Allergen [EPC]
Salt Form
Acetate
Variants
2
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 12 [hp_X]/mL | LIQUID | ORAL | 43857-0596 |
| 12 [hp_X]/mL | LIQUID | ORAL | 43857-0615 |
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Neurotox, you must consult a qualified healthcare professional.
Detailed information about Neurotox
Aluminum Acetate is a topical astringent and standardized chemical allergen used to treat inflammatory skin conditions. It works by precipitating proteins to dry and soothe skin irritations like dermatitis and poison ivy.
For the treatment of inflammatory skin conditions, Aluminum Acetate is typically used as a soak or a wet compress. The standard preparation involves dissolving one to three packets (or tablets) in 16 ounces (approx. 500 mL) of water to achieve the desired concentration.
Aluminum Acetate is generally considered safe for pediatric use when applied topically for short durations.
Patients with severe renal impairment (Stage 4 or 5 Chronic Kidney Disease) must use aluminum-containing products with extreme caution. While topical absorption is low, the inability to clear even small amounts of absorbed aluminum can lead to systemic accumulation. Consult a nephrologist before use.
No specific dosage adjustments are required for hepatic impairment, as aluminum is not metabolized by the liver. However, overall clinical status should be monitored.
Elderly patients often have thinner, more fragile skin (atrophic skin). The duration of contact should be monitored to prevent skin cracking or secondary irritation. Renal function should also be considered in this population.
Aluminum Acetate is for EXTERNAL USE ONLY. It must never be swallowed or injected.
If you miss a scheduled application, apply it as soon as you remember. If it is almost time for the next application, skip the missed dose and resume your regular schedule. Do not double the concentration of the solution to 'make up' for a missed dose.
Systemic overdose from topical application is highly unlikely in individuals with normal kidney function. However, accidental ingestion can occur.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose or concentration without medical guidance.
Most patients tolerate topical Aluminum Acetate well. However, because it is an astringent (drying agent), the most frequent side effects involve localized skin reactions:
Aluminum Acetate is intended for short-term, symptomatic relief of skin irritation. It is not a cure for underlying systemic allergies or chronic skin diseases. Patients should be aware that while it effectively manages 'weeping' symptoms, the primary cause of the skin reaction (such as an allergen or infection) must still be addressed by a healthcare professional.
No FDA black box warnings for Aluminum (Topical Aluminum Acetate).
While topical interactions are limited, certain combinations must be avoided to prevent chemical reactions on the skin:
Aluminum Acetate must NEVER be used in the following circumstances:
There are no adequate and well-controlled studies of topical Aluminum Acetate in pregnant women. Because systemic absorption is negligible when used as directed on intact skin, it is unlikely to pose a significant risk to the fetus. However, it should be used during pregnancy only if the potential benefit justifies the potential risk. Avoid application to large areas of the body for prolonged periods. There is no evidence of teratogenicity (birth defects) from topical aluminum use.
It is not known whether aluminum from topical application is excreted in human milk. However, because systemic levels remain very low, it is considered compatible with breastfeeding by most experts.
Aluminum Acetate acts as a topical astringent through the precipitation of organic proteins. When the $Al^{3+}$ ions come into contact with inflamed skin, they react with the proteins of the skin cells and the interstitial fluid. This reaction results in the formation of a protein-aluminum complex that 'shrinks' the tissue and constricts small blood vessels (capillaries). This reduces local edema (swelling) and stops the discharge of plasma from the wounded area. Furthermore, the acetate component maintains a mildly acidic environment (pH 4.5 to 5.5), which is hostile to many common skin pathogens like Staphylococcus aureus and Pseudomonas aeruginosa.
Common questions about Neurotox
Aluminum, specifically in the form of Aluminum Acetate (Burow's solution), is primarily used as a topical astringent to treat inflammatory skin conditions. It is highly effective for 'weeping' or 'oozing' skin rashes caused by poison ivy, poison oak, poison sumac, and insect bites. Additionally, it is used to treat swelling and infection in the outer ear canal (swimmer's ear). By precipitating proteins on the skin's surface, it helps dry out the affected area and reduce inflammation. It is also used as a standardized allergen in patch tests to diagnose specific skin allergies.
The most common side effects of topical Aluminum Acetate are localized to the area of application. Because it is a drying agent, many patients experience skin dryness, flaking, or a feeling of tightness. Some individuals may also notice mild stinging or redness immediately after applying the soak or compress. These effects are usually temporary and subside once the treatment is stopped. If the skin becomes excessively dry or starts to crack, the frequency of application should be reduced, and a healthcare provider should be consulted.
There are no known direct drug interactions between topical Aluminum Acetate and alcohol. Since the medication is applied to the skin and very little is absorbed into the bloodstream, alcohol does not interfere with how the drug works. However, alcohol consumption can sometimes worsen skin inflammation and dehydration, which might interfere with the healing process of the condition you are treating. It is generally advisable to stay well-hydrated and limit alcohol if you are dealing with a severe skin flare-up. Always follow the specific advice of your healthcare provider regarding lifestyle choices during treatment.
Topical Aluminum Acetate is generally considered safe during pregnancy when used as directed for short periods. Because very little of the medication is absorbed through the skin into the systemic circulation, the risk to the developing fetus is extremely low. However, as with all medications, pregnant women should consult their doctor before use, especially if they need to treat large areas of the body. There are no studies suggesting that topical aluminum causes birth defects or other pregnancy complications. It is best to use the lowest effective concentration for the shortest duration possible.
The astringent effects of Aluminum Acetate begin almost immediately upon contact with the skin. You will likely feel a cooling sensation and a reduction in itching within 5 to 15 minutes of applying a wet compress. For 'weeping' rashes, it may take 24 to 48 hours of regular use (applying every 6-8 hours) to see a significant drying of the lesions. If your skin condition does not show improvement within 7 days of use, you should stop the medication and contact your healthcare provider. It is not intended for long-term chronic use.
Yes, you can stop using topical Aluminum Acetate suddenly without experiencing any withdrawal symptoms. In fact, it is recommended to stop using the medication as soon as the 'weeping' or 'oozing' phase of your skin rash has resolved. Continued use on dry, healing skin can cause excessive dryness and cracking, which may actually slow down the final healing process. If the underlying cause of the rash (like an allergen) is still present, the rash may return, but this is not due to stopping the medication itself. Always monitor your skin's response and adjust use accordingly.
If you miss an application of Aluminum Acetate, simply apply it as soon as you remember. If it is almost time for your next scheduled application, skip the missed one and continue with your regular routine. Do not apply more solution or use a stronger concentration to make up for the missed dose, as this can lead to excessive skin irritation. Consistency helps in drying out 'weeping' rashes, but an occasional missed dose will not significantly impact the overall effectiveness of the treatment. Just resume your schedule as directed by your doctor.
No, topical Aluminum Acetate does not cause weight gain. Weight gain is typically a side effect associated with systemic medications like oral steroids or certain antidepressants that affect metabolism or appetite. Since Aluminum Acetate is applied only to the skin and has negligible systemic absorption, it does not enter the bloodstream in quantities large enough to affect your weight or metabolic processes. If you experience unexplained weight gain while using this medication, it is likely due to another cause and should be discussed with your healthcare provider.
Topical Aluminum Acetate can generally be used alongside other medications, but timing is important. If you are using other topical creams, such as steroids or antibiotics, you should apply the Aluminum Acetate soak first, dry the skin, and then apply the other medication. This prevents the soak from washing away your other treatments. However, you should avoid using it at the same time as alkaline soaps or collagenase ointments, as these can interact chemically on the skin. Always provide your doctor with a full list of all medications and supplements you are using.
Yes, Aluminum Acetate is widely available as a generic medication. It is most commonly found over-the-counter in the form of powder packets or effervescent tablets (often sold under the generic name 'Burow's Solution' or 'Astringent Solution'). Brand names like Domeboro are also popular, but the generic versions contain the same active ingredients and are equally effective for treating skin irritations. Generic versions are usually more cost-effective and are available at most major pharmacies and drugstores without a prescription.
Other drugs with the same active ingredient (Aluminum)
While topical aluminum is generally safe, certain situations require urgent medical intervention.
> Warning: Stop using Aluminum and call your doctor immediately if you experience any of the following:
Prolonged or chronic use of aluminum-containing soaks is not recommended. Long-term exposure to aluminum can lead to:
There are currently no FDA Black Box Warnings for topical Aluminum Acetate. However, it is critical to note that aluminum-containing products used in large volumes (such as certain antacids or parenteral nutrition) do carry warnings regarding aluminum toxicity in premature infants and patients with impaired kidney function. For the topical astringent form, the primary safety concern remains localized irritation and the risk of systemic absorption through compromised skin barriers in high-risk populations.
Report any unusual symptoms or persistent skin changes to your healthcare provider to ensure the treatment remains safe and effective for your specific condition.
For most patients using topical Aluminum Acetate for a few days, no specific lab tests are required. However, for certain groups, monitoring is essential:
Topical Aluminum Acetate does not typically affect the central nervous system and is not expected to impair your ability to drive or operate machinery. However, if you experience any unexpected dizziness or visual changes, stop use and contact your doctor.
There are no known direct interactions between topical Aluminum Acetate and alcohol consumption. However, alcohol can dehydrate the skin and may worsen certain inflammatory skin conditions like eczema. It is best to limit alcohol intake while treating active skin flares.
Aluminum Acetate should be discontinued once the 'weeping' or 'oozing' phase of the skin condition has resolved. Continued use on dry, healing skin can cause excessive cracking and delay the final stages of wound healing. There is no withdrawal syndrome associated with stopping topical aluminum, but the underlying skin condition may flare up if the trigger (e.g., poison ivy oil) has not been thoroughly removed from the environment.
> Important: Discuss all your medical conditions, especially kidney disease or history of skin allergies, with your healthcare provider before starting Aluminum.
For each major interaction, the management strategy is generally to separate the application times or to ensure the skin is thoroughly cleansed between different treatments.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, even if they are only applied to the skin.
Conditions requiring a careful risk-benefit analysis by a healthcare provider:
Patients who are sensitive to other metallic salts (such as nickel or cobalt) are generally NOT cross-sensitive to aluminum, as the chemical properties differ. However, patients sensitive to Calcium Acetate (often used as a stabilizer in aluminum powder packets) must avoid these specific formulations.
> Important: Your healthcare provider will evaluate your complete medical history, including any history of metal allergies or kidney problems, before prescribing or recommending Aluminum Acetate.
Aluminum Acetate is commonly used in children for contact dermatitis (poison ivy).
Elderly patients may be at higher risk for skin complications:
This is the most critical special population for aluminum-containing products.
No specific precautions are noted for patients with liver disease, as the liver does not play a role in the clearance or metabolism of aluminum ions.
> Important: Special populations require individualized medical assessment. Always inform your doctor if you are pregnant, planning to become pregnant, or have any degree of kidney disease.
| Parameter | Value |
|---|---|
| Bioavailability | <0.1% (Intact Skin) |
| Protein Binding | 70-90% (Systemic, primarily Transferrin) |
| Half-life | 24 hours to several days (Systemic) |
| Tmax | N/A (Topical) |
| Metabolism | None (Elemental) |
| Excretion | Renal (>95%) |
Aluminum Acetate is classified as a Topical Astringent. It is related to other aluminum salts like Aluminum Chloride (used in antiperspirants) and Aluminum Sulfate. Within the EPC system, it is recognized as a Standardized Chemical Allergen, reflecting its use in diagnostic immunology to identify contact hypersensitivities.