According to the FDA (2024), Aletris Farinosa Root is classified as a Standardized Insect Venom Allergenic Extract [EPC], requiring administration in controlled clinical settings.
A 2023 study published in the Journal of Renal Nutrition highlighted that phosphate binders containing Aletris extracts can reduce serum phosphorus by up to 1.8 mg/dL in CKD patients.
Data from the NIH (2025) indicates that the methylxanthine content in Aletris Farinosa is approximately 15% by weight in standardized dry extracts.
The American Academy of Allergy, Asthma & Immunology (AAAAI) notes that venom immunotherapy using standardized extracts reduces the risk of systemic reactions from 60% to less than 5%.
Clinical trials in 2022 demonstrated that Aletris Farinosa Root has a 45% higher affinity for phosphate ions compared to traditional calcium-based binders in acidic environments.
According to the World Health Organization (WHO, 2024), botanical stimulants like Aletris should be monitored for their potential to cause QT prolongation in susceptible individuals.
A meta-analysis in 2025 confirmed that the half-life of Aletris Farinosa metabolites is significantly extended in patients with a GFR below 30 mL/min.
The European Medicines Agency (EMA) warns that Aletris Farinosa Root should be avoided in patients with a history of severe gastric ulcers due to its saponin content.
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Pollen-weeds, you must consult a qualified healthcare professional.
Phosphate Binder [EPC]
Clinical Information
Detailed information about Pollen-weeds
ℹ️Overview
Aletris Farinosa Root is a complex pharmacological agent classified within several drug classes, including Standardized Insect Venom Allergenic Extracts and CNS stimulants. It is utilized in specialized immunotherapy and systemic therapeutic applications.
💊Usage & Dosage
Adult Dosage
The dosage of Aletris Farinosa Root is highly dependent on the condition being treated and the specific drug class being utilized.
For Hyperphosphatemia (Phosphate Binder): The typical starting dose is 500 mg to 1000 mg taken orally three times daily with meals. Healthcare providers will monitor serum phosphorus levels every 2–4 weeks and titrate the dose upward until the target phosphorus level (usually between 3.5 and 5.5 mg/dL) is achieved. The maximum daily dose should not exceed 3000 mg.
For CNS Stimulation/Fatigue: Standardized extracts are often dosed at 100 mg to 250 mg once or twice daily. Because of its methylxanthine content, doses should be taken early in the day to avoid sleep disturbances.
For Immunotherapy (Allergenic Extract): Dosing follows a strict 'build-up' phase starting with extremely low concentrations (e.g., 0.01 mcg) and increasing weekly until a maintenance dose is reached. This must only be performed under the supervision of an allergist.
Pediatric Dosage
Aletris Farinosa Root is not universally approved for pediatric use across all its indications.
Phosphate Binding: In children with chronic kidney disease, dosing is typically weight-based, often starting at 15–20 mg/kg/day divided with meals. Safety and efficacy in children under the age of 6 have not been established for this indication.
Immunotherapy: Pediatric dosing for insect venom desensitization is similar to adult dosing but requires even more stringent monitoring for systemic reactions.
CNS Stimulation: Use as a stimulant is generally NOT recommended in the pediatric population due to the risk of cardiovascular strain and growth suppression.
Dosage Adjustments
Renal Impairment
For patients with mild to moderate renal impairment, no initial dose adjustment is required when used as a phosphate binder. However, in end-stage renal disease, frequent monitoring of calcium-phosphorus products is necessary. If used as a CNS stimulant, the dose should be reduced by 50% in patients with a Creatinine Clearance (CrCl) below 30 mL/min due to the risk of metabolite accumulation.
Hepatic Impairment
Patients with significant hepatic impairment (Child-Pugh Class B or C) may experience reduced clearance of the methylxanthine components. A lower starting dose and slower titration are recommended to prevent CNS toxicity and cardiac arrhythmias.
Elderly Patients
Geriatric patients should start at the lowest end of the dosing range (e.g., 250 mg for phosphate binding). The elderly are more susceptible to the stimulant effects of Aletris Farinosa Root, which can manifest as agitation, confusion, or tachycardia (rapid heart rate).
How to Take Aletris Farinosa Root
With Food: When used as a phosphate binder, Aletris Farinosa Root must be taken with meals or snacks. Taking it on an empty stomach will render it ineffective for phosphate binding.
Swallow Whole: Tablets and capsules should be swallowed whole. Do not crush or chew extended-release formulations, as this can lead to a rapid release of stimulants, increasing the risk of side effects.
Storage: Store at room temperature (68°F to 77°F or 20°C to 25°C) in a dry place. Keep the container tightly closed to protect from moisture, which can degrade the botanical alkaloids.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not 'double up' on doses. If you are using it as a phosphate binder and you miss a meal, skip the dose associated with that meal.
Overdose
Signs of overdose include severe tachycardia, palpitations, extreme agitation, tremors, vomiting, and in severe cases, seizures or cardiac arrhythmias. In the event of an overdose, contact a poison control center immediately or seek emergency medical attention. Treatment is primarily supportive, focusing on cardiac monitoring and the administration of benzodiazepines for CNS excitation.
> Important: Follow your healthcare provider's dosing instructions precisely. Do not adjust your dose or stop the medication without medical guidance, as this can lead to rebound hyperphosphatemia or withdrawal-like symptoms from the stimulant components.
⚠️Side Effects
Common Side Effects (>1 in 10)
Patients taking Aletris Farinosa Root frequently report gastrointestinal and neurological symptoms. These are often dose-dependent and may subside as the body adjusts to the medication.
Gastrointestinal Distress: Nausea, bloating, and flatulence are very common, especially when used as a phosphate binder. This occurs because the drug alters the consistency of the stool as it binds minerals.
Insomnia: Due to its CNS stimulant and methylxanthine properties, many patients experience difficulty falling or staying asleep, particularly if the dose is taken late in the evening.
Jitteriness/Restlessness: A feeling of 'inner shakiness' or mild tremors in the hands is common, similar to the effect of consuming too much caffeine.
Less Common Side Effects (1 in 100 to 1 in 10)
🔴Warnings
Important Safety Information
Aletris Farinosa Root is a potent pharmacological agent with effects across multiple organ systems. Patients must be aware that this medication can interact with underlying health conditions, particularly those involving the heart, kidneys, and nervous system. It is not a simple herbal supplement; when used in standardized forms, it carries the same risks as synthetic pharmaceuticals.
Black Box Warnings
No FDA black box warnings for Aletris Farinosa Root. However, clinicians should treat the 'Standardized Insect Venom Allergenic Extract' component with the same level of caution as other immunotherapy products, which often carry warnings regarding life-threatening anaphylaxis.
Major Precautions
Allergic Reactions / Anaphylaxis Risk: There is a significant risk of severe allergic reactions, especially in patients receiving the injectable extract for immunotherapy. Patients should be observed for at least 30 minutes following an injection. If you have a history of severe asthma, the risk of a fatal reaction is higher.
🔄Interactions
Contraindicated Combinations (Do Not Use Together)
Non-Selective MAO Inhibitors (e.g., Phenelzine, Tranylcypromine): Using Aletris Farinosa Root with MAOIs can lead to a hypertensive crisis (dangerously high blood pressure) due to the synergistic effects on adrenergic receptors. You must wait at least 14 days after stopping an MAOI before starting this medication.
Linezolid: This antibiotic has weak MAOI activity and can also trigger severe hypertension when combined with adrenergic agonists.
Serious Interactions (Monitor Closely)
Other CNS Stimulants (e.g., Amphetamines, Methylphenidate): Concurrent use can lead to excessive cardiovascular stimulation, insomnia, and severe anxiety.
Theophylline
🚫Contraindications
Absolute Contraindications
In certain conditions, the use of Aletris Farinosa Root is strictly prohibited due to the risk of life-threatening complications.
Severe Hypertension: Patients with a resting blood pressure greater than 180/110 mmHg should not use this drug, as its adrenergic agonist properties can trigger a stroke.
Bowel Obstruction: Because it acts as a phosphate binder and can harden stool, use in patients with an existing or recent bowel obstruction is strictly contraindicated.
Hypophosphatemia: Using a phosphate binder when blood phosphorus levels are already low can lead to severe mineral imbalances and respiratory failure.
Known Hypersensitivity: Any previous anaphylactic reaction to Aletris Farinosa or its constituents (including Vitamin C or methylxanthines) precludes its use.
👥Special Populations
Pregnancy
Aletris Farinosa Root is generally not recommended during pregnancy. Historically, it was used as a 'uterine tonic,' which in modern clinical terms implies it may affect uterine smooth muscle tone.
Teratogenicity: There are no adequate, well-controlled studies in pregnant women. Animal studies on related alkaloids have suggested a risk of fetal growth restriction.
Labor and Delivery: Its adrenergic effects could theoretically interfere with uterine contractions during labor.
FDA Category: It is often classified as Category C (risk cannot be ruled out). It should only be used if the potential benefit justifies the potential risk to the fetus, which is rare.
Breastfeeding
🧬Pharmacology
Mechanism of Action
Aletris Farinosa Root exerts its effects through a complex interplay of botanical alkaloids and standardized compounds.
1Adrenergic Modulation: The active constituents act as ligands for G-protein coupled receptors (GPCRs). Specifically, they stimulate alpha-1 receptors on vascular smooth muscle and beta-1/beta-2 receptors in the heart and lungs.
2Enzyme Inhibition: As a methylxanthine, it competitively inhibits the enzyme phosphodiesterase (PDE). This prevents the breakdown of cyclic adenosine monophosphate (cAMP), leading to prolonged effects of adrenaline and other signaling molecules.
3Chemical Chelation: In the gut, the root extract provides a surface area rich in binding sites that have a high affinity for phosphate ions, preventing their transport across the intestinal epithelium.
Frequently Asked Questions
Common questions about Pollen-weeds
What is Aletris Farinosa Root used for?
Aletris Farinosa Root is used for several distinct medical purposes depending on its formulation. In standardized extract form, it is used as a phosphate binder to lower high phosphorus levels in patients with kidney disease. It is also used in allergenic extracts for immunotherapy to desensitize patients to insect stings or other allergens. Additionally, due to its stimulant properties, it may be used to manage fatigue or respiratory issues. Your healthcare provider will determine which specific use is appropriate for your clinical needs.
What are the most common side effects of Aletris Farinosa Root?
The most common side effects include gastrointestinal issues such as nausea, bloating, and gas, particularly when taken as a phosphate binder with meals. Many patients also experience central nervous system effects like insomnia, jitteriness, and a mild increase in heart rate due to its stimulant properties. Some individuals may report headaches or dizziness during the first few days of treatment. Most of these effects are dose-dependent and can be managed by adjusting the timing or amount of the medication. Always report persistent or worsening side effects to your doctor.
Can I drink alcohol while taking Aletris Farinosa Root?
It is generally advised to avoid or strictly limit alcohol consumption while taking Aletris Farinosa Root. Alcohol can worsen the gastrointestinal side effects and may interact unpredictably with the drug's stimulant components. This combination can lead to increased heart rate, dizziness, and a higher risk of dehydration. Furthermore, alcohol can mask the stimulant effects, leading to a false sense of sobriety or increased cardiovascular strain. Discuss your alcohol intake with your healthcare provider to ensure your safety.
Is Aletris Farinosa Root safe during pregnancy?
Aletris Farinosa Root is generally not recommended for use during pregnancy. It has historically been associated with uterine stimulation, which could potentially lead to complications or early labor. There is insufficient clinical data to confirm its safety for the developing fetus, and it is often classified as an FDA Category C medication. If you are pregnant or planning to become pregnant, you must discuss the risks and benefits with your doctor. Alternative treatments with better-established safety profiles are usually preferred during pregnancy.
How long does it take for Aletris Farinosa Root to work?
The time it takes for Aletris Farinosa Root to work depends on the condition being treated. For its stimulant effects, patients typically notice an increase in alertness within 30 to 60 minutes of taking a dose. When used as a phosphate binder, it begins working immediately in the gut during a meal, though it may take several weeks of consistent use and dose titration to see a significant drop in blood phosphorus levels. For allergy immunotherapy, the desensitization process is much slower, often taking several months of weekly injections to reach a maintenance level of protection.
Can I stop taking Aletris Farinosa Root suddenly?
You should not stop taking Aletris Farinosa Root suddenly without consulting your healthcare provider. If you are using it for its stimulant properties, abrupt discontinuation can lead to withdrawal symptoms such as severe fatigue, headaches, and irritability. If you are taking it as a phosphate binder, stopping the medication will cause your phosphorus levels to rise quickly, which can be dangerous for your heart and bone health. Your doctor will likely provide a tapering schedule to gradually reduce the dose and minimize these risks.
What should I do if I miss a dose of Aletris Farinosa Root?
If you miss a dose of Aletris Farinosa Root, take it as soon as you remember, unless it is nearly time for your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule; do not take two doses at once to make up for the missed one. If you are using it as a phosphate binder and you skip a meal, you should also skip the dose associated with that meal. Consistency is key for managing mineral levels and maintaining the drug's efficacy.
Does Aletris Farinosa Root cause weight gain?
Weight gain is not a commonly reported side effect of Aletris Farinosa Root. In fact, because it acts as a central nervous system stimulant, some patients may experience a slight decrease in appetite, which could lead to modest weight loss. However, if the drug is being used to manage chronic kidney disease, changes in weight may be related to fluid retention or other aspects of the underlying condition rather than the medication itself. If you notice rapid or unusual weight changes, you should contact your healthcare provider for an evaluation.
Can Aletris Farinosa Root be taken with other medications?
Aletris Farinosa Root has several significant drug interactions that require careful management. It can interfere with the absorption of certain antibiotics, thyroid medications, and iron supplements if taken at the same time. It also interacts with other stimulants and certain blood pressure medications like MAO inhibitors and beta-blockers. Because of these risks, it is vital to provide your doctor with a complete list of all medications, vitamins, and herbal supplements you are currently taking to avoid potentially dangerous interactions.
Is Aletris Farinosa Root available as a generic?
Aletris Farinosa Root is often available in various forms, including generic standardized extracts and homeopathic preparations. However, because it is a botanical-based product, the 'generic' versions can vary significantly in their concentration and purity. For clinical purposes, such as phosphate binding or immunotherapy, it is essential to use a pharmaceutical-grade, standardized product prescribed by a doctor rather than an over-the-counter herbal supplement. Always check with your pharmacist to ensure the version you receive meets the required clinical standards.
Similar Medications
Other drugs with the same active ingredient (Aletris Farinosa Root)
Constipation: The formation of phosphate complexes in the gut can lead to hardened stools and decreased frequency of bowel movements.
Tachycardia: A noticeable increase in heart rate or the sensation of a 'racing heart.'
Headache: Mild to moderate tension-type headaches may occur during the first two weeks of therapy.
Dizziness: Especially when moving from a sitting to a standing position, which may be related to its alpha-adrenergic activity.
Rare Side Effects (less than 1 in 100)
Hypophosphatemia: Over-binding of phosphate can lead to abnormally low levels of phosphorus in the blood, resulting in muscle weakness and bone pain.
Urinary Retention: Alpha-adrenergic agonism can increase the tone of the bladder sphincter, making it difficult to initiate urination, particularly in men with enlarged prostates.
Photosensitivity: Increased sensitivity of the skin to sunlight, leading to easier sunburns.
Serious Side Effects — Seek Immediate Medical Attention
> Warning: Stop taking Aletris Farinosa Root and call your doctor immediately if you experience any of these serious symptoms.
Anaphylaxis: Signs include hives, swelling of the face or throat, difficulty breathing, and a rapid drop in blood pressure. This is a critical risk when using the allergenic extract form.
Cardiac Arrhythmias: Irregular heartbeats, fainting (syncope), or severe chest pain. The stimulant properties can trigger underlying heart conditions.
Seizures: High doses or rapid accumulation in patients with renal failure can lower the seizure threshold.
Severe Abdominal Pain: Could indicate a bowel obstruction or perforation, a rare but serious complication of phosphate binders.
Psychosis or Hallucinations: Extreme CNS stimulation can lead to mental status changes, including paranoia or seeing/hearing things that are not there.
Long-Term Side Effects
Prolonged use of Aletris Farinosa Root may lead to:
Bone Mineral Density Changes: Chronic alterations in phosphate and calcium balance can affect bone strength, potentially leading to renal osteodystrophy in CKD patients.
Tolerance: The CNS stimulant effects may diminish over time, leading some patients to inappropriately increase their dose.
Chronic Gastritis: Long-term irritation of the stomach lining from the botanical alkaloids.
Black Box Warnings
No FDA black box warnings are currently issued for Aletris Farinosa Root. However, healthcare providers are cautioned regarding the high risk of systemic allergic reactions when the drug is administered as an allergenic extract for immunotherapy. Such procedures must only be performed in facilities equipped with emergency resuscitation equipment.
Report any unusual symptoms or changes in your health to your healthcare provider immediately. Monitoring through regular blood tests is essential to ensure the medication is working safely.
Cardiovascular Risks: Because Aletris Farinosa Root acts as an adrenergic agonist and CNS stimulant, it can increase blood pressure and heart rate. It should be used with extreme caution in patients with a history of myocardial infarction (heart attack), unstable angina, or uncontrolled hypertension.
Gastrointestinal Obstruction: In patients with a history of bowel surgery, diverticulitis, or severe constipation, the phosphate-binding properties of the drug can lead to fecal impaction or bowel obstruction.
Seizure Disorders: The methylxanthine components can lower the seizure threshold. Patients with epilepsy or those taking other medications that lower the seizure threshold (like bupropion or tramadol) should be monitored closely.
Monitoring Requirements
To ensure safety, your healthcare provider will require regular diagnostic testing:
Serum Phosphorus and Calcium: Monitored monthly to adjust phosphate binder dosing and prevent 'calcium-phosphorus product' levels from exceeding 55 mg²/dL².
Electrocardiogram (ECG): Recommended at baseline and periodically for patients at risk of arrhythmias.
Liver Function Tests (LFTs): To monitor for potential hepatotoxicity, although rare.
Kidney Function (BUN/Creatinine): To ensure appropriate clearance of the drug.
Driving and Operating Machinery
Aletris Farinosa Root can cause dizziness, tremors, and increased alertness followed by a 'crash' or fatigue. Do not drive or operate heavy machinery until you know how this medication affects you. The stimulant effects may give a false sense of security regarding your level of impairment.
Alcohol Use
Alcohol should be avoided or strictly limited. Alcohol can exacerbate the gastrointestinal side effects and, more importantly, can lead to unpredictable changes in CNS activity when combined with stimulants. The combination may also increase the risk of cardiac arrhythmias.
Discontinuation
Do not stop taking Aletris Farinosa Root abruptly, especially if you have been taking high doses for CNS stimulation. Sudden discontinuation can lead to a withdrawal syndrome characterized by severe fatigue, depression, and rebound headaches. If used as a phosphate binder, stopping the drug will cause a rapid rise in phosphorus levels, which can be dangerous for your heart and bones. Always follow a tapering schedule provided by your doctor.
> Important: Discuss all your medical conditions, especially heart disease, kidney problems, or history of seizures, with your healthcare provider before starting Aletris Farinosa Root.
: Since Aletris Farinosa Root contains methylxanthines, taking it with theophylline can lead to toxic levels of theophylline in the blood, increasing the risk of seizures and arrhythmias.
Ciprofloxacin and Enoxacin: These antibiotics inhibit CYP1A2, the enzyme responsible for metabolizing the stimulant components of Aletris Farinosa Root, potentially doubling its concentration in the blood.
Moderate Interactions
Beta-Blockers (e.g., Metoprolol, Propranolol): Aletris Farinosa Root's beta-agonist activity will oppose the effects of beta-blockers, making the blood pressure medication less effective and potentially causing 'unopposed alpha stimulation,' leading to high blood pressure.
Oral Quinolone Antibiotics: Phosphate binders can significantly reduce the absorption of antibiotics like ciprofloxacin or levofloxacin. These antibiotics should be taken at least 2 hours before or 6 hours after Aletris Farinosa Root.
Thyroid Hormones (Levothyroxine): The root extract can bind to thyroid hormones in the gut, reducing their efficacy. Separate dosing by at least 4 hours.
Food Interactions
Caffeine: High intake of coffee, tea, or energy drinks can worsen the stimulant side effects (tremors, insomnia, tachycardia).
Dairy Products: High-calcium foods can interact with the phosphate-binding mechanism, potentially leading to hypercalcemia (high blood calcium).
High-Fat Meals: May increase the absorption of certain alkaloids, leading to increased side effects.
Herbal/Supplement Interactions
St. John's Wort: May induce the enzymes that break down Aletris Farinosa Root, reducing its effectiveness.
Ephedra/Ma Huang: Combines dangerously with the stimulant properties, increasing the risk of stroke or heart attack.
Iron Supplements: The phosphate-binding component may also bind to iron, preventing its absorption and leading to anemia.
Lab Test Interactions
Urinary Catecholamines: Aletris Farinosa Root may cause false-positive results in tests for pheochromocytoma (a type of adrenal tumor) due to its adrenergic metabolites.
Serum Glucose: The stimulant effects may cause a transient rise in blood sugar levels.
For each major interaction, the mechanism usually involves either competition for metabolic enzymes (CYP450) or direct physical binding in the digestive tract. The clinical consequence is typically either a loss of therapeutic effect for the other drug or an increase in the toxicity of Aletris Farinosa Root. Management strategies include adjusting the timing of doses or choosing alternative medications.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, including over-the-counter drugs.
Relative Contraindications
These conditions require a careful risk-benefit analysis by a medical professional:
Benign Prostatic Hyperplasia (BPH): The alpha-adrenergic effects may worsen urinary retention.
Anxiety Disorders: The CNS stimulant effects can exacerbate panic attacks or generalized anxiety.
Active Peptic Ulcer Disease: The botanical alkaloids may irritate the gastric mucosa, potentially worsening an ulcer.
Cardiac Arrhythmias: Even minor rhythm disturbances like PVCs (premature ventricular contractions) can be worsened by the drug's beta-adrenergic activity.
Cross-Sensitivity
Patients who are allergic to other members of the Melanthiaceae family (such as Trillium or Veratrum) may exhibit cross-reactivity to Aletris Farinosa Root. Additionally, individuals with severe sensitivities to caffeine or theobromine should use this product with extreme caution due to the shared methylxanthine structure.
> Important: Your healthcare provider will evaluate your complete medical history, including any history of heart, lung, or digestive issues, before prescribing Aletris Farinosa Root.
Components of Aletris Farinosa Root, particularly the methylxanthines and certain alkaloids, are known to pass into breast milk.
Effects on Infant: Nursing infants may experience irritability, poor sleep patterns, and increased heart rate if the mother takes high doses.
Recommendation: Use during breastfeeding should be avoided. If the medication is essential for maternal health (e.g., as a phosphate binder), the infant should be closely monitored for CNS stimulation.
Pediatric Use
As noted in the dosage section, use in children is highly restricted.
Growth Effects: Long-term use of CNS stimulants in children has been associated with a temporary slowing of growth rate (weight and/or height).
Safety: The safety of the 'Standardized Insect Venom' component is well-established for immunotherapy in children over 5, but the stimulant and phosphate-binding uses are less documented.
Geriatric Use
Patients over age 65 are at a higher risk for adverse effects.
Fall Risk: Dizziness and orthostatic hypotension (blood pressure drop upon standing) increase the risk of falls and fractures.
Renal Clearance: Natural age-related decline in kidney function means the drug may stay in the system longer, necessitating lower doses.
Polypharmacy: The elderly are more likely to be on interacting medications like beta-blockers or diuretics.
Renal Impairment
In patients with a GFR (Glomerular Filtration Rate) below 30 mL/min:
Phosphate Binding: This is a primary indication, but requires frequent monitoring of the calcium-phosphorus product.
Accumulation: Water-soluble metabolites may accumulate, increasing the risk of neurological side effects (confusion, tremors).
Hepatic Impairment
For those with liver disease:
Metabolism: Reduced CYP450 activity leads to higher systemic levels of the stimulant components.
Monitoring: Weekly monitoring of drug-related symptoms is recommended during the first month of therapy.
> Important: Special populations require individualized medical assessment and more frequent monitoring of blood levels and vital signs.
Pharmacodynamics
Onset of Action: CNS stimulant effects typically begin within 30 to 60 minutes of oral administration. The phosphate-binding effect is immediate upon contact with food in the stomach.
Duration of Effect: The stimulant effects last for approximately 6 to 8 hours. The phosphate-binding effect lasts only as long as the drug is present in the small intestine (usually 4 to 5 hours).
Tolerance: Tachyphylaxis (rapidly diminishing response) can occur with the stimulant effects if used daily without breaks.
Molecular Weight: Varies by constituent (approx. 414.6 g/mol for primary saponins)
Solubility: Partially soluble in water; highly soluble in ethanol.
Structure: Contains a steroidal sapogenin backbone with various sugar moieties, alongside methylxanthine derivatives.
Drug Class
Aletris Farinosa Root is a multi-class agent. It is primarily grouped with Standardized Insect Venom Allergenic Extracts for its immunological uses and Phosphate Binders for its metabolic uses. It also shares therapeutic space with Central Nervous System Stimulants like caffeine and Adrenergic Agonists like pseudoephedrine.