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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Witch Hazel
Brand Name
Pre-moistened Medicated Wipes, Pre-moistened Medicated Wipes Witch Hazel 50%/hemorrhoidal Astringent, Walgreens Pre-moistened Medicated Wipes, Walgreens Pre-moistened Medicated Wipes Witch Hazel 50%/hemorrhoidal Astringent
Generic Name
Witch Hazel
Active Ingredient
Witch HazelCategory
Non-Standardized Plant Allergenic Extract [EPC]
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 50 mg/100mg | CLOTH | TOPICAL | 0363-1740 |
Detailed information about Pre-moistened Medicated Wipes, Pre-moistened Medicated Wipes Witch Hazel 50%/hemorrhoidal Astringent, Walgreens Pre-moistened Medicated Wipes, Walgreens Pre-moistened Medicated Wipes Witch Hazel 50%/hemorrhoidal Astringent
References used for this content
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Pre-moistened Medicated Wipes, Pre-moistened Medicated Wipes Witch Hazel 50%/hemorrhoidal Astringent, Walgreens Pre-moistened Medicated Wipes, Walgreens Pre-moistened Medicated Wipes Witch Hazel 50%/hemorrhoidal Astringent, you must consult a qualified healthcare professional.
Witch Hazel is a topical astringent and skin protectant derived from the Hamamelis virginiana plant, classified as a Non-Standardized Plant Allergenic Extract [EPC] used for minor skin irritations and hemorrhoidal relief.
For the treatment of minor skin irritations, insect bites, or stings, adults may apply Witch Hazel solution or gel to the affected area up to 3 to 4 times daily. For anorectal use (hemorrhoids), the area should be cleansed with mild soap and warm water and rinsed thoroughly before application. Medicated pads or wipes can be used to pat the area gently up to 6 times daily or after each bowel movement. If using the liquid solution for hemorrhoids, it can be applied using a clean cotton ball or soft cloth.
In the context of 'weeping' skin conditions like poison ivy, a compress may be used. Soak a clean cloth in Witch Hazel and apply it to the affected area for 15 to 20 minutes, several times a day. Do not exceed the frequency recommended on the product packaging unless specifically directed by a physician.
Witch Hazel is generally considered safe for children aged 2 years and older when used as a topical astringent. The application frequency is the same as for adults (up to 3 to 4 times daily). For children under the age of 2, there is no standardized OTC dosage, and a pediatrician must be consulted before use. Parents should ensure that children do not ingest the product, especially distilled versions containing alcohol, as this can lead to toxicity.
Since Witch Hazel is applied topically and has negligible systemic absorption, no dosage adjustments are typically required for patients with renal impairment. However, patients with end-stage renal disease should avoid applying large quantities over extensive areas of broken skin.
There are no specific dosage adjustments for patients with hepatic impairment due to the lack of systemic involvement.
Elderly patients often have thinner, more fragile skin (dermatoporosis). While no specific dose reduction is required, healthcare providers may recommend less frequent application to prevent excessive drying or cracking of the skin, which could lead to secondary infections.
Witch Hazel is for EXTERNAL USE ONLY. It should never be swallowed or injected.
If you miss an application of Witch Hazel, apply it as soon as you remember. If it is almost time for the next application, skip the missed dose and resume your regular schedule. Do not 'double up' the amount applied to make up for a missed dose.
Systemic overdose from topical application is extremely unlikely. However, if the product is ingested, it can cause significant gastrointestinal distress, including nausea, vomiting, and diarrhea. Because most commercial Witch Hazel contains 14-15% ethanol, ingestion by a child can lead to alcohol poisoning.
Signs of Ingestion Overdose:
In case of accidental ingestion, contact a Poison Control Center (1-800-222-1222 in the US) or seek emergency medical attention immediately.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose or use the product for longer than 7 consecutive days without medical guidance.
Witch Hazel is generally well-tolerated, but the most common side effects involve localized skin reactions. These are typically mild and subside once the product is washed off or use is discontinued.
Witch Hazel is intended for external use only. It is not for ophthalmic (eye), oral, or intravaginal use. If the product gets into the eyes, rinse thoroughly with cool water for several minutes. If irritation persists, contact an ophthalmologist. Patients with sensitive skin should perform a 'patch test' on a small area of the forearm before applying it to larger or more sensitive areas like the face or anorectal region.
No FDA black box warnings for Witch Hazel.
There are no documented 'never-use' drug-drug interactions for topical Witch Hazel. However, it should not be used simultaneously on the same patch of skin with other potent astringents or resorcinol-containing products, as this can lead to severe skin desiccation and irritation.
Witch Hazel is generally considered safe for use during pregnancy when applied topically for short periods (e.g., for the treatment of pregnancy-induced hemorrhoids). Because systemic absorption is negligible, the risk to the developing fetus is considered extremely low. There are no documented cases of teratogenicity (birth defects) associated with the topical use of Hamamelis virginiana. However, pregnant women should avoid ingesting any form of Witch Hazel. Always consult with an obstetrician before starting any new medication during pregnancy, especially in the first trimester.
There is no data on the excretion of Witch Hazel components into human breast milk. However, due to the minimal systemic absorption from topical application, it is highly unlikely that any clinically significant amount would reach the nursing infant.
Precautions: If applying Witch Hazel to the chest or breast area, ensure the product is thoroughly washed off before breastfeeding to prevent the infant from accidentally ingesting the liquid or experiencing skin irritation from contact.
Witch Hazel acts as a local astringent through the physical-chemical action of its tannins. These tannins (gallotannins and hamamelitannins) bind to and precipitate proteins on the surface of cells and within the interstitial fluid. This protein precipitation leads to several physiological effects:
Common questions about Pre-moistened Medicated Wipes, Pre-moistened Medicated Wipes Witch Hazel 50%/hemorrhoidal Astringent, Walgreens Pre-moistened Medicated Wipes, Walgreens Pre-moistened Medicated Wipes Witch Hazel 50%/hemorrhoidal Astringent
Witch Hazel is primarily used as a topical astringent to relieve minor skin irritations, such as those caused by insect bites, stings, or minor scrapes. It is also a very common treatment for the itching, burning, and discomfort associated with hemorrhoids and other anorectal conditions. Many people use it as a facial toner to help manage oily skin and reduce the appearance of pores, although this is more of a cosmetic application. Additionally, it can help dry up 'weeping' skin rashes caused by plants like poison ivy or poison oak. Always ensure you are using it externally and follow the directions on the product label.
The most common side effects of Witch Hazel are localized to the area where it is applied and include skin dryness, mild stinging, and temporary redness. Because many Witch Hazel products contain alcohol, they can strip the skin of its natural oils, leading to flaking or a feeling of tightness if used too frequently. Some individuals with sensitive skin may experience a mild itchy rash or contact dermatitis. These effects are usually minor and go away once the product is washed off. If you experience severe burning, blistering, or swelling, you should stop using the product and consult a healthcare provider.
Yes, you can generally consume alcohol if you are using Witch Hazel topically, as the drug does not enter your bloodstream in significant amounts. There are no known systemic interactions between ingested alcohol and the tannins or volatile oils found in Witch Hazel. However, you should never ingest Witch Hazel itself, as many preparations contain 14-15% ethanol and high concentrations of tannins that can be toxic to the stomach and liver. If you are using Witch Hazel for a condition that might be worsened by alcohol consumption (like certain skin inflammations), your doctor might advise you to limit alcohol for general health reasons. Always use the product as directed on the skin only.
Witch Hazel is generally considered safe for topical use during pregnancy, especially for common issues like pregnancy-related hemorrhoids or skin irritation. Since it is applied to the skin and very little is absorbed into the body, it poses a minimal risk to the developing baby. However, it is always best to consult with your OB/GYN or healthcare provider before starting any new treatment while pregnant. You should avoid using it on large areas of the body or on broken skin for extended periods. Never ingest Witch Hazel during pregnancy, as internal use has not been proven safe for the fetus.
Witch Hazel works very quickly, with its astringent 'tightening' effect usually felt within a few minutes of application. For the relief of itching or burning from insect bites or hemorrhoids, most patients notice a soothing sensation almost immediately due to the cooling effect of the alcohol and the vasoconstriction caused by the tannins. However, for the reduction of swelling or the drying of 'weeping' rashes, it may take several applications over 24 to 48 hours to see significant improvement. If your symptoms do not improve after 7 days of consistent use, you should contact a healthcare professional for further evaluation.
Yes, you can stop using Witch Hazel at any time without any risk of withdrawal symptoms or physical dependence. It is a topical treatment that acts locally on the skin surface and does not alter your body's internal chemistry in a way that requires a tapering period. However, if you are using it to manage a chronic condition like oily skin or hemorrhoidal discomfort, your symptoms may return once you stop applying the astringent. If you were using it for a specific rash and it hasn't fully healed, stopping too early might allow the irritation to persist. There is no harm in stopping 'cold turkey' if you experience a side effect or no longer need the treatment.
If you miss an application of Witch Hazel, simply apply it as soon as you remember. If it is almost time for your next scheduled application, skip the missed one and continue with your regular routine. Since Witch Hazel is used for symptomatic relief, missing a dose will not cause a medical emergency; it may just mean that your symptoms, like itching or swelling, return sooner. Do not apply an extra large amount of the product to make up for the missed application, as this will not make it work better and may only increase skin dryness. Consistency is helpful for conditions like poison ivy, but occasional missed doses are not a major concern.
No, Witch Hazel does not cause weight gain. It is a topical medication that is applied to the skin and is not absorbed into the systemic circulation in any amount that could affect your metabolism, appetite, or fat storage. It does not contain hormones, calories, or any ingredients that influence body weight. If you notice weight gain while using Witch Hazel, it is likely due to other factors such as diet, lifestyle, or other medications you may be taking. You should discuss any unexpected changes in your weight with your healthcare provider to identify the underlying cause.
Witch Hazel is generally safe to use alongside most oral medications because it stays on the surface of the skin and does not interact with drugs inside your body. However, you should be cautious when using it with other topical medications applied to the same area. For example, using Witch Hazel with other drying agents like acne creams (benzoyl peroxide) or prescription retinoids can cause severe skin irritation and peeling. It is always a good idea to wait for one topical product to dry completely before applying another. Tell your doctor or pharmacist about all the products you use, including herbal supplements and over-the-counter skin care items.
Witch Hazel is widely available as a generic product and is often sold as 'Witch Hazel USP' or 'Hamamelis Water.' Because it is an older, botanical-based treatment, it is not protected by patents, and many different companies manufacture their own versions. You can find generic Witch Hazel in almost every pharmacy, grocery store, and big-box retailer. Generic versions are typically just as effective as brand-name versions, provided they contain the standard 14% alcohol and are distilled from the *Hamamelis virginiana* plant. Always check the 'Drug Facts' label on the bottle to ensure the active ingredient is Witch Hazel and to see if any extra fragrances or preservatives have been added.
Other drugs with the same active ingredient (Witch Hazel)
> Warning: Stop using Witch Hazel and call your doctor immediately if you experience any of these serious symptoms. While rare with topical use, they require clinical evaluation.
Chronic use of Witch Hazel as a facial toner or skin treatment can lead to chronic xerosis (abnormally dry skin). Over time, this can compromise the skin barrier function, making the individual more susceptible to environmental allergens and secondary bacterial infections (like impetigo). There is no evidence that long-term topical use leads to systemic organ toxicity, but the skin's natural microbiome may be temporarily altered by the antimicrobial properties of the tannins and alcohol.
No FDA black box warnings for Witch Hazel. It is considered a low-risk topical agent when used according to the OTC monograph guidelines.
Report any unusual symptoms or persistent skin changes to your healthcare provider. Monitoring the skin for signs of infection (pus, warmth, increasing pain) is essential during use.
There are no routine laboratory tests (like blood counts or liver panels) required for the use of topical Witch Hazel. However, patients should self-monitor the treated area for:
Topical Witch Hazel does not affect the central nervous system and is not expected to impair the ability to drive or operate heavy machinery.
There is no known interaction between consumed alcohol and topical Witch Hazel. However, as many Witch Hazel extracts contain alcohol, those with a history of alcohol use disorder should be aware of the ethanol content if they have a high risk of accidental or intentional ingestion.
Witch Hazel can be stopped abruptly without the risk of withdrawal symptoms or 'rebound' effects. If being used for inflammatory conditions, the symptoms may gradually return if the underlying cause has not been addressed.
> Important: Discuss all your medical conditions, especially any history of chronic skin diseases like eczema or psoriasis, with your healthcare provider before starting Witch Hazel.
There are no known food interactions with the topical use of Witch Hazel. It does not interact with grapefruit juice, dairy, or high-fat meals.
Witch Hazel is not known to interfere with standard blood, urine, or imaging tests. If used as an 'Allergenic Extract' for skin prick testing, it may interfere with the interpretation of other plant allergens if the patient has a baseline sensitivity to Witch Hazel itself.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking, even those applied to the skin.
There is a theoretical risk of cross-sensitivity between Witch Hazel and other members of the Hamamelidaceae family (such as Sweetgum or Fothergilla). Patients who have reacted to other botanical astringents containing high amounts of gallotannins should use Witch Hazel with caution.
> Important: Your healthcare provider will evaluate your complete medical history and skin type before recommending the use of Witch Hazel for therapeutic purposes.
Witch Hazel is frequently used in children for insect bites and diaper rash (though the latter should be done under medical advice). It is generally safe for children over 2 years old. In younger infants, the skin is much thinner and more permeable, increasing the risk of irritation and minor systemic absorption of the alcohol content. Always seek pediatric guidance for infants under 24 months.
In the elderly, the skin's natural moisture barrier is often diminished. While Witch Hazel is safe, geriatric patients should be monitored for 'over-drying' of the skin. If used for hemorrhoids, the elderly should be cautioned about the risk of dizziness if they are applying the product while straining or in a prolonged crouched position, though the drug itself does not cause orthostatic hypotension.
No dose adjustments are necessary for patients with kidney disease. The lack of systemic absorption ensures that the kidneys are not burdened by the clearance of the drug's active constituents.
No dose adjustments are required for patients with liver disease. While tannins can be hepatotoxic if ingested in large quantities, topical application does not reach the liver in any measurable concentration.
> Important: Special populations require individualized medical assessment to ensure that the benefits of topical therapy outweigh any potential risks to skin integrity or systemic health.
| Parameter | Value |
|---|---|
| Bioavailability | <1% (Topical) |
| Protein Binding | High (Local/Surface) |
| Half-life | N/A (Local Action) |
| Tmax | Immediate (Local) |
| Metabolism | Negligible (Systemic) |
| Excretion | Physical removal |
Witch Hazel is classified therapeutically as an Astringent and Skin Protectant. Within the EPC (Established Pharmacologic Class) system, it is categorized as a Non-Standardized Plant Allergenic Extract, reflecting its botanical origin and its potential to induce or test for allergic sensitivities in specialized clinical settings.