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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Human Growth Hormone, Hypophysis Suis, Hepar Suis
Brand Name
Vital Age Defiance
Generic Name
Human Growth Hormone, Hypophysis Suis, Hepar Suis
Active Ingredient
Pork LiverCategory
Standardized Pollen Allergenic Extract [EPC]
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 6 [hp_X]/mL | SPRAY | ORAL | 50845-0199 |
Detailed information about Vital Age Defiance
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Vital Age Defiance, you must consult a qualified healthcare professional.
Pork Liver is a complex biological substance used clinically as an allergenic extract for diagnostic testing and as a concentrated source of essential nutrients like Vitamin B12 and iron.
Dosage for Pork Liver varies significantly based on the intended use (diagnostic vs. therapeutic).
For skin prick testing, a single drop of the 1:20 w/v (weight/volume) non-standardized extract is applied to the forearm or back. The results are typically read 15 to 20 minutes after application. Intradermal testing may use a more dilute solution (e.g., 1:1000) if the prick test is negative but clinical suspicion remains high.
When used as a source of iron or B12, the standard adult dose of desiccated pork liver is typically 1,500 mg to 3,000 mg per day, divided into two or three doses. This provides a concentrated source of heme iron (approximately 1-2 mg per gram of desiccated liver).
Pediatric skin testing follows the same protocol as adults, though the number of simultaneous tests may be limited to prevent discomfort. The extract should only be administered by a board-certified allergist.
Pork liver supplements are generally not recommended for children unless under the direct supervision of a pediatrician or pediatric hematologist. The high concentration of Vitamin A poses a risk of toxicity in smaller bodies.
No specific adjustments are required for diagnostic testing. For oral supplementation, patients with chronic kidney disease (CKD) should monitor their phosphorus and protein intake, as liver is high in both.
Use with caution in patients with pre-existing liver disease. While it provides nutrients, the liver's role in processing fat-soluble vitamins means that patients with cirrhosis may be at higher risk for Vitamin A toxicity.
Elderly patients often have reduced gastric acid (hypochlorhydria), which may impair the absorption of Vitamin B12 from liver extracts. However, the heme iron remains well-absorbed.
This must be performed in a clinical setting equipped to handle anaphylaxis. The skin is cleaned with alcohol, the extract is applied, and a sterile lancet is used to prick the epidermis.
If you miss a dose of a pork liver supplement, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up.
An overdose of Pork Liver extract primarily manifests as acute Vitamin A or Iron toxicity.
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance.
When ingested as a supplement, Pork Liver is generally well-tolerated, but common side effects may include:
> Warning: Stop taking Pork Liver and call your doctor immediately if you experience any of these.
Prolonged use of Pork Liver supplements (months to years) requires monitoring for:
There are currently no FDA Black Box Warnings specifically for Pork Liver allergenic extracts. However, all allergenic extracts carry a general warning regarding the risk of severe systemic reactions, including anaphylaxis, and must only be administered by trained healthcare professionals.
Report any unusual symptoms to your healthcare provider.
Pork Liver is a potent biological agent. Patients must be aware that 'natural' does not mean 'risk-free.' The high concentration of preformed vitamins and minerals means that Pork Liver can behave more like a drug than a food when taken in extract form.
No FDA black box warnings for Pork Liver. However, diagnostic extracts must include a warning that they are intended for use by physicians experienced in the diagnosis and treatment of allergies and that emergency equipment must be available.
If you are taking Pork Liver supplements long-term, your doctor may require the following tests:
Pork Liver does not typically cause sedation or cognitive impairment. However, if a systemic allergic reaction occurs during testing, patients should not drive until cleared by a medical professional.
Alcohol should be consumed with caution. Both alcohol and Pork Liver (via Vitamin A) are processed by the liver. Concurrent heavy alcohol use can increase the risk of liver toxicity from the Vitamin A found in the extract.
There is no known withdrawal syndrome associated with Pork Liver. However, if taking it for anemia, stopping the supplement abruptly may cause a return of fatigue and other deficiency symptoms. Always discuss tapering or stopping with your provider.
> Important: Discuss all your medical conditions with your healthcare provider before starting Pork Liver.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Pork Liver.
Pregnancy Category: Not Formally Assigned (Handle with Caution).
Pork Liver is a 'double-edged sword' in pregnancy. It is an excellent source of folate and iron, which are vital for fetal development. However, it contains preformed Vitamin A (retinol). According to the Teratology Society, intake of preformed Vitamin A exceeding 10,000 IU per day has been linked to cranial neural crest defects in infants. Pregnant women should limit Pork Liver intake to once a week or use it only under strict medical supervision.
Nutrients from Pork Liver pass into breast milk. While this can improve the nutritional profile of the milk (especially B12), excessive Vitamin A intake by the mother can lead to high levels in the infant. Normal dietary amounts are considered safe, but concentrated extracts should be used cautiously.
In children, Pork Liver is primarily used for allergy testing. As a supplement, it is rarely used due to the risk of iron and Vitamin A toxicity. A child's liver is smaller and less able to handle the massive 'vitamin load' found in concentrated porcine extracts.
Elderly patients may benefit from the high B12 content of Pork Liver, as age-related gastric atrophy often reduces B12 absorption from other foods. However, the risk of gout and the potential for Vitamin A to decrease bone density (increasing fracture risk) must be weighed carefully.
Patients with end-stage renal disease (ESRD) often have issues with phosphorus clearance. Pork Liver is high in phosphorus and should be limited in the renal diet to prevent secondary hyperparathyroidism.
In patients with cirrhosis or hepatitis, the liver's ability to store and process Vitamin A is compromised. Using Pork Liver extracts in these patients can lead to 'portal hypertension' or worsened liver injury due to the accumulation of retinol in the remaining healthy stellate cells.
> Important: Special populations require individualized medical assessment.
Pork Liver functions as a biological matrix. As an allergenic extract, it contains porcine serum albumin and other proteins that act as antigens. As a therapeutic agent, its primary molecular action is via the provision of Heme Iron, which bypasses the standard iron-regulated hepcidin pathway more effectively than inorganic iron. It also acts as an Androgen Receptor Agonist [MoA] through the various steroid precursors naturally synthesized in the porcine liver.
The onset of action for allergy testing is rapid (15-20 minutes). For nutritional purposes, the rise in serum B12 can be seen within 24-48 hours, while the improvement in hemoglobin levels typically takes 2-4 weeks of consistent use. There is no known 'tolerance' development to the nutrients, but the body has a finite capacity to store the fat-soluble vitamins contained within.
| Parameter | Value |
|---|---|
| Bioavailability | 15-35% (Iron), >60% (B12 with IF) |
| Protein Binding | 90% (Retinol-binding protein) |
| Half-life | 50-200 days (Vitamin A in liver) |
| Tmax | 3-6 hours (Post-ingestion) |
| Metabolism | Hepatic (Retinol esterification) |
| Excretion | Renal (B-vitamins), Biliary (Vitamin A) |
Pork Liver is not a single molecule but a complex biological extract. It consists of approximately 70% water, 20% protein, and 5% lipids. Its primary active chemical constituents include Cyanocobalamin, Retinyl Palmitate, and Ferritin. It is soluble in aqueous diagnostic buffers but remains a suspension in its desiccated form.
Pork Liver is classified as a Non-Standardized Food Allergenic Extract [EPC]. It is related to other glandular extracts and mammalian allergenic products like Beef Extract and Cat Dander Extract.
Common questions about Vital Age Defiance
Pork Liver is primarily used in two clinical areas: diagnostic allergy testing and nutritional therapy. In allergy clinics, it is used as a non-standardized extract to identify patients with pork allergies or Pork-Cat Syndrome. Nutritionally, it is used as a highly bioavailable source of heme iron and Vitamin B12 for patients with specific types of anemia. Some healthcare providers also use it in glandular therapy to support liver health, although this is considered an alternative medical use. It is one of the most nutrient-dense substances available, providing essential amino acids and fat-soluble vitamins.
The most common side effects associated with Pork Liver supplements include gastrointestinal issues such as nausea, stomach upset, and a metallic taste in the mouth. Many patients will notice that their stools become very dark or black; this is a normal and harmless result of the high iron content in the liver. If used as a skin test, the most common side effect is a localized itchy bump (wheal) at the site of the test. Some people may also experience mild headaches or a slight change in body odor due to the high concentration of vitamins and proteins.
It is generally advised to limit alcohol consumption while taking concentrated Pork Liver extracts. Both alcohol and the high levels of Vitamin A found in Pork Liver are processed by your own liver. Combining them can place undue stress on the organ and increase the risk of hepatotoxicity (liver damage). Furthermore, alcohol can interfere with the absorption of some B-vitamins found in the extract. If you have a history of liver disease, you should avoid this combination entirely and consult your doctor.
Pork Liver should be used with extreme caution during pregnancy, particularly in the first trimester. While it provides essential iron and folate, it is also the highest food source of preformed Vitamin A (retinol). Excessive intake of preformed Vitamin A (over 10,000 IU per day) has been scientifically linked to serious birth defects. Most doctors recommend limiting liver consumption to no more than once a week for pregnant women. Always check with your obstetrician before taking any desiccated liver supplements while pregnant.
The 'onset time' for Pork Liver depends on what you are using it for. For allergy testing, the results are visible within 15 to 20 minutes. If you are taking it to treat an iron or B12 deficiency, you may begin to feel an increase in energy levels within a few days to a week. however, it typically takes 4 to 6 weeks of consistent use to see a significant increase in red blood cell counts or hemoglobin levels on a blood test. Your doctor will likely monitor your blood work periodically to track your progress.
Yes, you can generally stop taking Pork Liver supplements suddenly without experiencing withdrawal symptoms, as it is a biological nutrient source rather than a habit-forming drug. However, if you were taking it to manage a chronic deficiency like pernicious anemia, your symptoms of fatigue and weakness may return shortly after you stop. It is always best to discuss your plans to discontinue any supplement with your healthcare provider to ensure your nutritional needs are being met through other means.
If you miss a dose of your Pork Liver supplement, take it as soon as you remember. However, if it is almost time for your next scheduled dose, you should skip the missed dose and simply take the next one at the regular time. Do not take two doses at once to make up for the one you missed. Since Pork Liver contains fat-soluble vitamins that stay in your system for a long time, a single missed dose will not significantly impact your overall treatment or nutritional status.
Pork Liver itself is not typically associated with significant weight gain when taken in standard supplemental doses, as the capsules are low in calories. However, because it is very effective at resolving anemia and improving metabolic function through its B-vitamin and iron content, some patients may experience an increase in appetite as their health improves. If you notice unexpected or rapid weight gain, you should discuss this with your doctor, as it may be related to other underlying health factors or changes in your diet.
Pork Liver can interact with several medications, so it is vital to disclose its use to your doctor. It should not be taken with retinoid medications (like those for acne) because of the risk of Vitamin A toxicity. It may also interact with certain antibiotics (tetracyclines) and blood thinners like Warfarin. Additionally, because it contains small amounts of natural hormones and minerals, it can interfere with thyroid medications or other mineral supplements. Always space out your medications and supplements as directed by a pharmacist.
Pork Liver is a biological substance and is not 'patented' in the same way as synthetic drugs, so it is available from many different manufacturers under various brand names and as generic desiccated liver powder. For allergy testing, the extracts are produced by specialized biological laboratories. While the 'active ingredient' is the same, the concentration and purity can vary between brands. It is recommended to choose a reputable, pharmaceutical-grade source to ensure the product is free from contaminants and accurately labeled.
Other drugs with the same active ingredient (Pork Liver)