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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Antimon. Crud., Bryonia, Calc.carb., Causticum, Dulcamara, Graphites, Lycopodium, Merc. Sulph. Rub., Nat. Carb., Nitricum Ac., Nux Vom., Rhus Toxicodendron, Sabina, Sepia, Silicea, Staphysag., Sulphur, Thuja Occ., Taraxacum
Brand Name
Warts
Generic Name
Antimon. Crud., Bryonia, Calc.carb., Causticum, Dulcamara, Graphites, Lycopodium, Merc. Sulph. Rub., Nat. Carb., Nitricum Ac., Nux Vom., Rhus Toxicodendron, Sabina, Sepia, Silicea, Staphysag., Sulphur, Thuja Occ., Taraxacum
Active Ingredient
Antimony TrisulfideCategory
Standardized Chemical Allergen [EPC]
Variants
4
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 15 [hp_X]/g | PELLET | ORAL | 55714-2577 |
| 15 [hp_X]/mL | LIQUID | ORAL | 55714-2576 |
| 15 [hp_X]/mL | LIQUID | ORAL | 55714-4849 |
References used for this content
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Warts, you must consult a qualified healthcare professional.
| 15 [hp_X]/g | PELLET | ORAL | 55714-4850 |
Detailed information about Warts
Antimony Trisulfide is a standardized chemical allergen used primarily in diagnostic patch testing to identify contact dermatitis. It belongs to the class of standardized chemical allergens and is monitored for its specific immunological and biochemical interactions.
In the context of diagnostic testing, the dosage of Antimony Trisulfide is standardized based on the surface area of the patch test.
Antimony Trisulfide is not routinely approved for pediatric use unless a specific occupational or environmental exposure is suspected in an older adolescent. Because children's skin is more permeable and their immune systems are still developing, healthcare providers exercise extreme caution. If used, the concentration may be adjusted, but there is no standardized pediatric dosing protocol established by the FDA for this specific chemical allergen.
Since diagnostic patch testing involves negligible systemic absorption, dosage adjustments for renal impairment are generally not required. However, in the rare event of systemic exposure, the clearance of antimony would be significantly reduced in patients with a GFR (Glomerular Filtration Rate) below 30 mL/min, increasing the risk of heavy metal accumulation.
No specific adjustments are required for topical diagnostic use. However, patients with severe hepatic disease should be monitored for any unusual systemic responses, as the liver is a primary site for the sequestration of heavy metals.
Elderly patients may have thinner skin (atrophy), which can lead to increased irritation or a higher rate of false-positive results. Healthcare providers may choose to use a smaller patch or a slightly lower concentration to avoid excessive irritation.
Antimony Trisulfide is administered exclusively by a healthcare professional.
In diagnostic testing, a 'missed dose' usually refers to a patch that has fallen off prematurely. If the patch is removed or falls off before the 48-hour mark, the test may be invalidated. Patients should contact their clinic immediately to determine if the patch needs to be reapplied or if the test needs to be rescheduled.
Systemic overdose from a diagnostic patch test is virtually impossible. However, 'overdose' in this context may present as an extreme localized skin reaction, known as a 'bullous' reaction (blistering).
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose or remove diagnostic patches without medical guidance.
Because Antimony Trisulfide is used to trigger a reaction in sensitive individuals, 'side effects' are often the intended diagnostic outcome.
Antimony Trisulfide is a heavy metal derivative and must be handled with care. Its use is strictly limited to diagnostic environments. Patients with a known history of severe metal toxicity or those with active, widespread dermatitis (known as 'Angry Back' or 'Excited Skin Syndrome') should postpone testing, as this can lead to false-positive results across all test sites.
No FDA black box warnings for Antimony Trisulfide.
Antimony Trisulfide must NEVER be used in the following circumstances:
Antimony Trisulfide is generally classified as Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Animal reproduction studies have shown that some antimony compounds can cross the placental barrier. While the amount used in a diagnostic patch test is extremely small and systemic absorption is negligible, the general clinical consensus is to avoid elective diagnostic patch testing during pregnancy. If testing is deemed absolutely necessary (e.g., for an acute, debilitating occupational dermatosis), a thorough risk-benefit analysis must be conducted by the obstetrician and dermatologist.
It is unknown whether antimony from a topical patch test is excreted in human milk. However, because systemic absorption is minimal, the risk to a nursing infant is considered very low. To ensure safety, the patch should never be applied to the breast or chest area where the infant might come into direct contact with the compound or the tape.
Antimony Trisulfide is not frequently used in young children. The immune system of a child is still maturing, and their skin is thinner and more absorbent than adult skin. Diagnostic testing in children is typically reserved for cases where a specific environmental or medical exposure is strongly suspected. There are no standardized 'normal' values for pediatric antimony patch tests, so results must be interpreted with extreme caution by a specialist.
Antimony Trisulfide acts as a Type IV Allergen. Its molecular mechanism involves acting as a hapten that binds to skin proteins, creating an antigenic complex. This complex triggers the activation of T-lymphocytes.
Furthermore, the provided data indicates that Antimony Trisulfide is associated with Acetylcholine Release Inhibitors [MoA] and Adrenergic alpha-Agonists [MoA]. In biochemical models, antimony ions can interfere with the calcium-dependent release of neurotransmitters. By blocking calcium channels or displacing calcium ions, antimony may inhibit the release of acetylcholine at the neuromuscular junction. Its adrenergic activity suggests it may mimic or enhance the effects of catecholamines at alpha and beta receptors, though these effects are typically only relevant in toxicology or high-dose experimental pharmacology rather than diagnostic use.
Common questions about Warts
Antimony Trisulfide is primarily used as a diagnostic tool in dermatology called a patch test. It helps healthcare providers determine if a patient has a specific allergy to antimony, which is a metal often found in industrial settings, electronics, and some textiles. When applied to the skin in a controlled, standardized amount, it can trigger a localized immune response in people who are sensitized. This information is crucial for patients who suffer from chronic skin rashes (dermatitis) and need to identify the environmental cause. It is not used as a medication to treat a disease, but rather as a way to map out a patient's immune system sensitivities.
The most common side effects are localized to the area where the diagnostic patch was applied. These include redness, intense itching, and sometimes small bumps or blisters, which are actually the signs of a positive allergic reaction. Some patients may also notice temporary skin discoloration or a mild 'sunburn' sensation at the site. These symptoms usually appear within 48 to 96 hours after application and can last for one to two weeks. While uncomfortable, these reactions are generally limited to the test site and do not affect the rest of the body.
There is no known direct chemical interaction between topical Antimony Trisulfide and alcohol consumption. However, alcohol is a vasodilator, meaning it widens blood vessels and can cause the skin to flush or become redder. This can make it difficult for your dermatologist to accurately read the results of your patch test, as they need to distinguish between an allergic reaction and simple skin flushing. For the most accurate diagnostic results, many healthcare providers recommend avoiding or limiting alcohol for the 48 to 96 hours that the test is being evaluated. Always follow the specific instructions provided by your testing clinic.
Antimony Trisulfide is generally avoided during pregnancy as a matter of precaution. While the amount of the chemical used in a patch test is very small and very little of it enters the bloodstream, there is a lack of comprehensive safety data regarding its effects on a developing fetus. Most dermatologists recommend delaying elective diagnostic testing until after delivery. If the skin condition is severe and requires immediate diagnosis to manage, your doctor will perform a careful risk-benefit analysis. It is essential to inform your healthcare provider if you are pregnant or planning to become pregnant before starting the test.
In a diagnostic context, Antimony Trisulfide works through a delayed-type hypersensitivity reaction, which takes time to develop. After the patch is applied to your back, it must remain in place for 48 hours to allow the chemical to interact with your immune cells. Even after the patch is removed, the reaction often continues to develop, which is why a second 'reading' is usually performed at 72 or 96 hours. Therefore, the entire process takes about three to four days to yield a final result. You will not see an immediate reaction like you might with a hay fever skin prick test.
Antimony Trisulfide is not a long-term medication, so the concept of 'stopping' it suddenly does not apply in the traditional sense. It is applied once as a diagnostic patch and then removed by your doctor after 48 hours. There are no withdrawal symptoms or physical dependencies associated with this compound. However, you should not remove the diagnostic patch yourself before the scheduled appointment unless instructed by your doctor due to a severe reaction. Removing the patch early can result in a false-negative test, meaning an allergy could be missed.
Since Antimony Trisulfide is administered by a healthcare professional during a scheduled office visit, missing a 'dose' usually means missing your appointment for patch application or removal. If your patch falls off at home, you should not try to tape it back on yourself. Instead, call your dermatologist's office immediately. They will determine if the test can be salvaged or if you need to start the process over. Timing is critical for the accuracy of these tests, so keeping your scheduled appointments for both application and the follow-up readings is essential.
No, Antimony Trisulfide does not cause weight gain. It is a chemical used in very small amounts for topical diagnostic testing and does not affect the body's metabolism or appetite. Weight gain is typically associated with systemic medications like oral steroids or certain psychiatric drugs, whereas Antimony Trisulfide is a heavy metal compound used locally on the skin. Even in cases of industrial exposure where higher amounts might be inhaled, weight gain is not a recognized symptom of antimony toxicity. Any changes in weight should be discussed with your doctor to find the actual cause.
Antimony Trisulfide can be used while taking most medications, but certain drugs that suppress the immune system can interfere with the test results. For example, if you are taking oral steroids like prednisone or using strong steroid creams on your back, the test may show a 'false negative' because your immune system's ability to react is being suppressed. It is vital to provide your doctor with a full list of all medications, including vitamins and herbal supplements, before the test. Most other medications for blood pressure, heart health, or diabetes do not interfere with the results of a patch test.
Antimony Trisulfide is a basic chemical compound rather than a branded pharmaceutical product. In the medical field, it is produced by specialized laboratory companies that create standardized allergenic extracts for diagnostic use. While there aren't 'brand name' vs. 'generic' versions in the way there are for pills like Tylenol, different companies may manufacture the patch test strips. Your doctor will select a standardized version that meets FDA requirements for purity and concentration to ensure the results are reliable and safe.
Other drugs with the same active ingredient (Antimony Trisulfide)
> Warning: Stop taking Antimony Trisulfide (remove the patch) and call your doctor immediately if you experience any of these.
Antimony Trisulfide diagnostic testing does not typically result in long-term side effects. However, there is a theoretical risk of active sensitization. This occurs when the test itself causes the patient to become allergic to antimony for the first time. If this happens, the patient may react to antimony in the future (e.g., when wearing certain jewelry or handling industrial materials).
No FDA black box warnings are currently issued for Antimony Trisulfide in its capacity as a standardized chemical allergen. However, healthcare providers must be aware of the general risks associated with allergenic extracts, including the potential for severe systemic allergic reactions in highly predisposed individuals.
Report any unusual symptoms to your healthcare provider. You may also report side effects to the FDA at 1-800-FDA-1088.
Antimony Trisulfide does not typically affect the ability to drive or operate machinery. However, if the patch is placed in a way that limits movement or if the patient experiences a rare systemic reaction, caution is advised.
There are no known direct interactions between topical Antimony Trisulfide and alcohol. However, alcohol can cause vasodilation (widening of blood vessels), which might increase skin redness and complicate the reading of the test results.
There is no 'withdrawal' or 'tapering' required for Antimony Trisulfide, as it is a one-time diagnostic application. Once the patch is removed and the site is cleaned, the substance is no longer active on the skin.
> Important: Discuss all your medical conditions with your healthcare provider before starting Antimony Trisulfide testing.
For each major interaction, the management strategy is usually timing. The healthcare provider will schedule the test for a time when the patient is not using interfering medications.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking before undergoing diagnostic testing.
Patients who are allergic to Antimony Trisulfide may also show cross-sensitivity to other group 15 elements, such as Arsenic or Bismuth. While not identical, the chemical similarity of these metals can sometimes lead to overlapping immune recognition. Additionally, patients sensitive to other heavy metals like Nickel or Cobalt are statistically more likely to have multiple metal sensitivities.
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Antimony Trisulfide diagnostic testing.
In patients over the age of 65, the skin's immune response (cell-mediated immunity) may be slightly diminished. This can lead to weaker positive reactions that are harder to interpret. Furthermore, elderly patients are more likely to have 'atrophic' skin, which is more prone to irritation from the adhesive tape used to secure the patches. Healthcare providers should monitor for skin tears or localized infection in this population.
For the purposes of a one-time diagnostic patch test, renal impairment does not require a dose adjustment. However, if a patient has end-stage renal disease (ESRD), their ability to clear any incidentally absorbed antimony is reduced. While the risk is minimal, the provider should be aware of the patient's renal status in case of an accidental systemic exposure.
No specific adjustments are needed for hepatic impairment in the context of diagnostic patch testing. The liver is involved in the processing of heavy metals, but the micro-doses used in dermatology do not place a significant burden on hepatic function.
> Important: Special populations require individualized medical assessment to ensure the safety and accuracy of diagnostic procedures.
| Parameter | Value |
|---|---|
| Bioavailability | < 1% (Topical) |
| Protein Binding | High (Albumin and Erythrocytes) |
| Half-life | 24 hours (Initial); 30-100 days (Terminal) |
| Tmax | 48-72 hours (for skin reaction) |
| Metabolism | Non-enzymatic (Redox) |
| Excretion | Renal (80%), Fecal (20%) |
Antimony Trisulfide is a member of the Standardized Chemical Allergen [EPC] class. It is related to other metal allergens such as Nickel Sulfate, Cobalt Chloride, and Potassium Dichromate. It is also categorized under Standardized Plant/Food/Fungal Allergenic Extracts in broader regulatory lists due to its inclusion in comprehensive diagnostic panels.