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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Weight Management Formula
Brand Name
Weight Management Formula
Generic Name
Weight Management Formula
Active Ingredient
Alpha Lipoic AcidCategory
Calculi Dissolution Agent [EPC]
Variants
1
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 3 [hp_X]/59mL | LIQUID | ORAL | 63083-7534 |
Detailed information about Weight Management Formula
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Weight Management Formula, you must consult a qualified healthcare professional.
Alpha Lipoic Acid is a potent antioxidant and Calculi Dissolution Agent used primarily for diabetic neuropathy and metabolic support. It functions as a co-factor in energy metabolism and exhibits unique acidifying and calcium-chelating activities.
The dosage of Alpha Lipoic Acid can vary significantly based on the condition being treated and the patient's overall health status. For Diabetic Neuropathy, the standard clinical dose typically ranges from 600 mg to 1,800 mg per day. Healthcare providers often start patients at 600 mg once daily to assess tolerance. For general Antioxidant Support, lower doses of 100 mg to 300 mg daily are common. When used as a Calculi Dissolution Agent, the dosage is highly individualized and must be managed by a specialist, often involving divided doses to maintain consistent urinary pH levels. In clinical trials, doses up to 2,400 mg have been used, but higher doses significantly increase the risk of gastrointestinal distress and hypoglycemia (low blood sugar).
Alpha Lipoic Acid is generally not approved for use in pediatric populations unless specifically directed by a pediatric specialist for rare metabolic disorders. There is insufficient clinical data to establish a safe and effective dose for children under the age of 18. Parents should never administer ALA to children without direct medical supervision, as the risk of severe hypoglycemia is significantly higher in younger patients.
Patients with significant kidney disease (low GFR) may require dosage adjustments. While ALA is primarily metabolized by the liver, its metabolites are renally excreted. Clinical monitoring of renal function is advised for those on long-term, high-dose therapy.
Since the liver is the primary site for the beta-oxidation of Alpha Lipoic Acid, patients with hepatic cirrhosis or severe liver dysfunction should be monitored closely. Dose reductions may be necessary to prevent accumulation of the drug.
Geriatric patients often have a higher prevalence of reduced renal and hepatic clearance. Furthermore, the elderly are at an increased risk for falls if ALA causes unexpected hypoglycemia. Healthcare providers typically recommend starting at the lowest possible dose (e.g., 100-200 mg) and titrating upward slowly.
To ensure maximum efficacy, Alpha Lipoic Acid should be taken according to the following guidelines:
If you miss a dose of Alpha Lipoic Acid, take it as soon as you remember. However, if it is nearly time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up, as this increases the risk of toxicity and acute hypoglycemia.
Signs of an Alpha Lipoic Acid overdose may include severe nausea, vomiting, diarrhea, and profound hypoglycemia (symptoms include shakiness, sweating, confusion, and rapid heartbeat). In extreme cases, massive overdoses (above 6,000 mg) have been associated with multi-organ failure, seizures, and metabolic acidosis. If an overdose is suspected, contact emergency services or a poison control center immediately. Treatment is primarily supportive, focusing on glucose management and electrolyte balance.
> Important: Follow your healthcare provider's dosing instructions precisely. Do not adjust your dose or stop taking this medication without medical guidance, especially if you are using it for chronic condition management.
Alpha Lipoic Acid is generally well-tolerated, but some patients may experience mild to moderate side effects. The most frequently reported issues include:
> Warning: Stop taking Alpha Lipoic Acid and call your doctor immediately if you experience any of the following serious symptoms:
With prolonged use, Alpha Lipoic Acid is generally considered safe; however, long-term high-dose therapy requires monitoring of thiamine levels. Because ALA can interfere with thiamine (Vitamin B1) utilization, chronic users—especially those who consume alcohol regularly—may be at risk for B1 deficiency. Additionally, long-term effects on thyroid function have been suggested, as ALA may decrease the conversion of T4 to T3 (the active thyroid hormone).
No FDA black box warnings currently exist for Alpha Lipoic Acid. However, clinical guidelines emphasize the critical need for monitoring in diabetic patients due to the potent glucose-lowering effects that can mimic or enhance the action of insulin and oral hypoglycemic agents.
Report any unusual symptoms or persistent side effects to your healthcare provider to ensure your treatment plan remains safe and effective.
Alpha Lipoic Acid is a potent metabolic agent with significant systemic effects. It is not a simple vitamin and must be treated with the same caution as any pharmacological intervention. Patients should be aware that ALA can significantly alter blood glucose levels and may interact with hormonal pathways due to its Estrogen and Androgen Receptor Agonist properties.
There are currently no FDA black box warnings for Alpha Lipoic Acid. It is classified as a dietary supplement in the U.S. but is a regulated pharmaceutical in several European countries. Despite the lack of a black box warning, the risk of Insulin Autoimmune Syndrome is a recognized clinical concern that requires medical awareness.
Healthcare providers typically require the following monitoring for patients on therapeutic doses of Alpha Lipoic Acid:
Alpha Lipoic Acid may cause dizziness or blurred vision if it induces hypoglycemia. Patients should not drive or operate heavy machinery until they know how ALA affects them and are confident their blood sugar levels are stable.
Alcohol consumption should be strictly limited while taking Alpha Lipoic Acid. Alcohol increases the risk of thiamine deficiency, and the combination with ALA can exacerbate this, potentially leading to neurological damage. Furthermore, alcohol can interfere with blood sugar regulation, making the effects of ALA unpredictable.
While ALA does not typically require a tapering schedule, stopping it suddenly in a diabetic patient may lead to a rapid increase in blood sugar levels (hyperglycemia). Always consult your doctor before discontinuing the medication to ensure your other treatments are adjusted accordingly.
> Important: Discuss all your medical conditions, including diabetes, thyroid issues, and alcohol history, with your healthcare provider before starting Alpha Lipoic Acid.
There are few absolute contraindications for Alpha Lipoic Acid; however, it should NEVER be used in combination with:
Alpha Lipoic Acid can interfere with certain laboratory results:
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking. The chelating and metabolic properties of Alpha Lipoic Acid make it highly interactive.
Alpha Lipoic Acid must NEVER be used in the following circumstances:
Conditions requiring a careful risk-benefit analysis include:
Patients who are sensitive to other sulfur-containing compounds or dithiol-based chelating agents (such as Dimercaprol) may exhibit cross-sensitivity to Alpha Lipoic Acid. If you have a history of reacting to 'sulfa' drugs, discuss this with your doctor, although the chemical structure of ALA is distinct from sulfonamides.
> Important: Your healthcare provider will evaluate your complete medical history, including your genetic profile (specifically HLA status for Hirata disease risk), before prescribing Alpha Lipoic Acid.
Alpha Lipoic Acid is currently categorized as Pregnancy Category B/C (depending on the jurisdiction). While animal studies have not shown direct teratogenic (birth defect-causing) effects at standard doses, there are no well-controlled studies in pregnant women. Some research suggests ALA might be beneficial in managing gestational diabetes or preventing oxidative stress in pregnancy, but this is experimental. It should only be used during pregnancy if the potential benefit clearly outweighs the risk to the fetus. Use during the first trimester is generally discouraged.
It is not known whether Alpha Lipoic Acid is excreted in human breast milk. Because of its small molecular weight and lipophilic nature, it is likely to pass into milk. Due to the potential for serious adverse reactions in nursing infants—specifically the risk of hypoglycemia—a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Alpha Lipoic Acid is not approved for use in children. The pediatric population is exceptionally sensitive to the glucose-lowering effects of ALA. There have been reported cases of accidental ingestion in children leading to severe toxicity, including status epilepticus (prolonged seizures) and multi-organ failure. Keep all ALA products out of the reach of children.
Clinical studies have shown that elderly patients may have a higher sensitivity to the effects of Alpha Lipoic Acid. The risk of hypoglycemia is particularly concerning in this age group, as it can lead to falls, fractures, and cognitive impairment. Furthermore, the Anti-coagulant [EPC] effects of ALA may be more pronounced in the elderly, who are often already taking medications like aspirin or warfarin. Dose titration should be conservative.
In patients with mild to moderate renal impairment, no specific dose adjustment is usually required. However, in patients with end-stage renal disease (ESRD) or those on dialysis, the pharmacokinetics of ALA metabolites are significantly altered. While ALA is not effectively removed by hemodialysis due to protein binding, its metabolites may accumulate. Close monitoring of electrolytes and blood sugar is necessary.
Alpha Lipoic Acid undergoes extensive hepatic metabolism. In patients with Child-Pugh Class B or C hepatic impairment, the clearance of ALA is reduced. This can lead to higher systemic exposure and an increased risk of side effects. Healthcare providers may reduce the daily dose by 50% or more in these patients.
> Important: Special populations require individualized medical assessment. Never start Alpha Lipoic Acid if you fall into one of these categories without a thorough consultation with a specialist.
Alpha Lipoic Acid acts as a biological antioxidant and a metabolic co-factor. Specifically, it is a co-enzyme for the pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes, which are central to the citric acid cycle (Krebs cycle) and ATP production. Its unique pharmacological profile includes Acidifying Activity [MoA], which aids in the dissolution of calculi, and Calcium Chelating Activity [MoA], where it binds to divalent metal ions. Furthermore, its role as an Ammonium Ion Binding Activity [MoA] agent facilitates the urea cycle. Its ability to regenerate other antioxidants like Vitamin C and Vitamin E makes it a 'network antioxidant.'
The pharmacodynamic effects of ALA are dose-dependent. Its glucose-lowering effect is achieved by increasing the translocation of glucose transporter-4 (GLUT4) to the cell membranes, mimicking the action of insulin. The onset of its antioxidant effects can be seen within hours, but the therapeutic benefits for nerve conduction and neuropathy typically require 3 to 5 weeks of consistent dosing. Tolerance to ALA does not typically develop, but its effects on the thyroid and blood sugar require ongoing monitoring.
| Parameter | Value |
|---|---|
| Bioavailability | 20% - 38% (Reduced by food) |
| Protein Binding | 80% - 90% (Primarily Albumin) |
| Half-life | 30 - 60 Minutes |
| Tmax | 0.5 - 2.0 Hours |
| Metabolism | Hepatic (Beta-oxidation) |
| Excretion | Renal (80% - 90% as metabolites) |
Alpha Lipoic Acid is classified therapeutically as a Calculi Dissolution Agent [EPC] and a metabolic antioxidant. It is related to other thiol-containing compounds and vitamins, often grouped with the Vitamin B-complex analogs due to its co-enzyme functions.
Common questions about Weight Management Formula
Alpha Lipoic Acid is primarily used to treat symptoms of diabetic peripheral neuropathy, such as pain, burning, and tingling in the arms and legs. It is also clinically recognized as a Calculi Dissolution Agent, helping to manage certain types of mineral stones in the body. Beyond these uses, it is employed as a potent antioxidant to combat oxidative stress and support healthy glucose metabolism. Some healthcare providers also use it as a nitrogen-binding agent for specific metabolic conditions. Always use it under the guidance of a professional to ensure it matches your clinical needs.
The most common side effects of Alpha Lipoic Acid include gastrointestinal issues such as nausea, stomach upset, and vomiting. Some patients may also experience a mild skin rash, dizziness, or a metallic taste in the mouth. These effects are usually mild and often decrease if the dosage is adjusted by a doctor. However, because it can lower blood sugar, symptoms of hypoglycemia like shakiness and sweating are also common. If these symptoms become severe, you should contact your healthcare provider immediately.
It is strongly advised to avoid or strictly limit alcohol consumption while taking Alpha Lipoic Acid. Alcohol can interfere with the body's levels of thiamine (Vitamin B1), and ALA can further complicate thiamine utilization, potentially leading to serious neurological issues like Wernicke-Korsakoff syndrome. Additionally, alcohol can cause unpredictable fluctuations in blood sugar, which increases the risk of severe hypoglycemia when combined with ALA. For your safety, discuss your alcohol intake with your doctor before starting this treatment.
The safety of Alpha Lipoic Acid during pregnancy has not been fully established through large-scale human clinical trials. While animal studies have not shown significant harm, it is currently categorized as Pregnancy Category B/C. Most doctors recommend avoiding its use during pregnancy unless there is a clear medical necessity that outweighs the potential risks to the developing fetus. If you are pregnant or planning to become pregnant, you must consult your obstetrician before using ALA. It is also generally avoided during breastfeeding due to the risk of hypoglycemia in the infant.
The time it takes for Alpha Lipoic Acid to show results depends on the condition being treated. While its antioxidant effects begin shortly after ingestion, the symptomatic relief for diabetic neuropathy typically takes between 3 to 5 weeks of consistent use. For metabolic or calculi-related issues, the timeline may be longer and requires ongoing clinical monitoring. It is important to continue taking the medication as prescribed even if you do not feel an immediate difference. Do not stop the treatment early without consulting your healthcare provider.
You should not stop taking Alpha Lipoic Acid suddenly without first consulting your doctor, especially if you are using it to manage diabetic neuropathy or blood sugar. Sudden discontinuation can lead to a rapid spike in blood glucose levels, which may complicate your diabetes management. While ALA does not cause traditional withdrawal symptoms, your body needs time to adjust its metabolic processes. Your healthcare provider will help you safely transition off the medication if necessary. Always follow a medically supervised plan for discontinuation.
If you miss a dose of Alpha Lipoic Acid, you should take it as soon as you remember, provided it is not too close to your next scheduled dose. If your next dose is only a few hours away, skip the missed dose entirely and return to your regular schedule. Never take two doses at once to make up for a missed one, as this significantly increases the risk of side effects and dangerous hypoglycemia. Keeping a consistent schedule is key to the effectiveness of the treatment. If you frequently miss doses, consider using a pill reminder.
Alpha Lipoic Acid is generally not associated with weight gain; in fact, some clinical studies suggest it may assist with modest weight loss. By improving insulin sensitivity and supporting mitochondrial energy metabolism, ALA may help the body process glucose more efficiently. Some patients report a reduction in appetite while taking ALA, which can contribute to weight management. However, it should not be viewed as a primary weight loss drug. Any changes in weight while taking ALA should be discussed with your healthcare provider to ensure they are healthy and expected.
Alpha Lipoic Acid can interact with several types of medications, making it vital to disclose your full medication list to your doctor. It most notably interacts with insulin and oral diabetes drugs, potentially causing dangerously low blood sugar. It can also interfere with thyroid medications like levothyroxine and chemotherapy drugs like cisplatin. Because of its chelating properties, it should not be taken at the same time as mineral supplements like iron, magnesium, or calcium. Your pharmacist can help you create a dosing schedule that avoids these interactions.
Yes, Alpha Lipoic Acid is widely available as a generic product and is sold under many different brand names and as a dietary supplement. In countries where it is a prescription drug, generic versions are the standard for treating neuropathy. Because it is available over-the-counter in many regions, the quality can vary between manufacturers. It is recommended to choose a reputable brand that follows Good Manufacturing Practices (GMP) or to use the specific version prescribed by your healthcare provider to ensure you are receiving a consistent and effective dose.
Other drugs with the same active ingredient (Alpha Lipoic Acid)