Loading...
Loading...
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Brand Name
Wheat Berry
Generic Name
Wheat Berry
Active Ingredient
WheatCategory
Non-Standardized Food Allergenic Extract [EPC]
Variants
8
Different strengths and dosage forms
| Strength | Form | Route | NDC |
|---|---|---|---|
| 100 [hp_C]/1 | PELLET | ORAL | 37662-3362 |
| 200 [hp_C]/1 | PELLET | ORAL | 37662-3363 |
| 10 [hp_M]/1 | PELLET | ORAL | 37662-3366 |
This page is for informational purposes only and does not replace medical advice. Before using any prescription or over-the-counter medication for Wheat Berry, you must consult a qualified healthcare professional.
| 500 [hp_C]/1 | PELLET | ORAL | 37662-3364 |
| 6 [hp_C]/1 | PELLET | ORAL | 37662-3359 |
| 12 [hp_C]/1 | PELLET | ORAL | 37662-3360 |
| 30 [hp_C]/1 | PELLET | ORAL | 37662-3361 |
| 1 [hp_M]/1 | PELLET | ORAL | 37662-3365 |
Detailed information about Wheat Berry
Wheat (Triticum aestivum) is utilized in clinical medicine primarily as a non-standardized food allergenic extract for diagnosis and immunotherapy, while specific extracts also function as estrogen receptor agonists and endocrine modulators.
Dosage for Wheat extracts is highly individualized and must be determined by a specialist (Allergist/Immunologist) based on the patient's sensitivity levels. There is no 'standard' dose for non-standardized extracts.
Wheat extracts are used in children, but extreme caution is required. Pediatric dosing follows the same escalation principles as adult dosing, but starting concentrations may be even more dilute depending on the child's history of reactive symptoms. Clinical studies suggest that children may be more prone to rapid systemic reactions; therefore, the 'starting dose' is often determined by the results of the skin prick test.
No specific dose adjustments are typically required for renal impairment when using allergenic extracts, as the protein load is minimal. However, patients with renal failure may have altered skin reactivity, potentially leading to false-negative diagnostic results.
There are no established guidelines for Wheat extract dosage in hepatic impairment. However, if using wheat-derived estrogenic compounds, hepatic clearance of lignan metabolites may be reduced.
Elderly patients may have reduced skin turgor and reactivity, which can affect the interpretation of diagnostic tests. Additionally, the risk of cardiovascular complications during a systemic reaction (anaphylaxis) is higher in this population, necessitating more conservative dosing.
Wheat allergenic extracts are never for self-administration at home. They must be administered in a clinical setting.
If a dose of Wheat immunotherapy is missed, do not double the next dose. If the interval since the last dose is too long (e.g., more than 7–10 days past the scheduled date), the healthcare provider may need to reduce the dose for safety before resuming the build-up.
An overdose of Wheat allergenic extract usually manifests as a severe systemic allergic reaction (anaphylaxis).
> Important: Follow your healthcare provider's dosing instructions. Do not adjust your dose without medical guidance.
Most patients receiving Wheat allergenic extracts will experience some form of local reaction. These are generally not dangerous but can be uncomfortable.
Wheat extracts are potent biological substances. They should only be used by physicians who are specifically trained in the diagnosis and treatment of allergic diseases. The primary safety concern is the unpredictability of systemic reactions. Even if a patient has tolerated previous doses well, the next dose could trigger a severe reaction due to factors like recent illness, exercise, or changes in other medications.
As noted previously, Wheat extracts contain a Black Box Warning regarding the risk of anaphylaxis. Healthcare providers must have 'crash carts' equipped with epinephrine, oxygen, and airway management tools readily available whenever Wheat extracts are administered.
Wheat extracts must NEVER be used in the following circumstances:
Wheat allergenic extracts are classified as Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. The primary concern is not the extract itself, but the potential for a systemic reaction (anaphylaxis) in the mother. Anaphylaxis causes a sudden drop in blood pressure, which can lead to placental hypoperfusion and fetal distress or death.
It is not known whether wheat proteins or their metabolites are excreted in human milk. However, since these are naturally occurring proteins, the risk to a nursing infant is considered minimal. The mother should be monitored for systemic reactions, as the medications used to treat such reactions (like high-dose antihistamines) may temporarily reduce milk supply.
Wheat (Triticum aestivum) allergenic extracts function through the IgE-mediated hypersensitivity pathway. The extract contains a complex mixture of proteins, including:
Upon administration, these proteins bind to specific IgE antibodies on the surface of mast cells and basophils. This cross-linking triggers the degranulation of these cells, releasing histamine, leukotrienes, and prostaglandins. In the context of the Estrogen Receptor Agonist MoA, wheat lignans bind to the ligand-binding domain (LBD) of ER-β with higher affinity than ER-α, inducing a conformational change that allows the receptor to act as a transcription factor for estrogen-responsive genes.
Common questions about Wheat Berry
In clinical medicine, Wheat is primarily used as an allergenic extract for the diagnosis and treatment of wheat allergies. Healthcare providers use it in skin prick tests to identify if a patient has an IgE-mediated sensitivity to wheat proteins. It can also be used in specialized immunotherapy protocols to help desensitize the immune system over time. Additionally, certain wheat-derived compounds are studied for their estrogenic properties and their ability to interact with the endocrine system. It is never used for self-treatment and must be administered by a specialist.
The most frequent side effects are localized to the site of the injection or skin test. Patients often experience redness, itching, and a raised bump known as a wheal, which usually appears within 15 to 20 minutes. Some people may also develop 'large local reactions' where the swelling spreads several inches across the arm and lasts for a day or two. While these are common and usually harmless, they must be monitored by a doctor. Systemic symptoms like hives or wheezing are less common but require immediate medical attention.
It is strongly recommended that you avoid alcohol on the days you receive a Wheat injection. Alcohol acts as a vasodilator, meaning it widens your blood vessels and increases blood flow to the skin. This can cause the wheat proteins in the injection to be absorbed into your bloodstream much faster than intended, significantly increasing your risk of a severe systemic allergic reaction or anaphylaxis. Always wait at least 24 hours after your injection before consuming alcohol. Discuss your lifestyle habits with your allergist to ensure the safest treatment plan.
Wheat extracts are generally not started during pregnancy because of the risk of anaphylaxis, which can be dangerous for both the mother and the developing baby. If a woman is already on a stable maintenance dose of Wheat immunotherapy and becomes pregnant, her doctor may choose to continue the treatment since the risk of a reaction is lower at that stage. However, the dose is typically not increased during pregnancy. There is no evidence that the extract itself causes birth defects, but the physiological stress of an allergic reaction is a major concern. Always inform your doctor if you are pregnant or planning to become pregnant.
Wheat immunotherapy is a long-term commitment and does not provide immediate relief. The 'build-up' phase, where doses are gradually increased, usually lasts 3 to 6 months. Most patients do not begin to see a significant reduction in their allergic sensitivity until they have been on a 'maintenance dose' for several months. A full course of treatment typically lasts 3 to 5 years to ensure long-lasting immune tolerance. Your doctor will perform periodic skin tests or blood tests to monitor your progress and determine when it is safe to stop.
While stopping Wheat immunotherapy suddenly will not cause physical withdrawal symptoms like a traditional drug might, it will halt the process of building immune tolerance. If you stop the injections before the recommended 3-to-5-year period, your allergy symptoms are likely to return over time. If you need to stop due to side effects or financial reasons, you should consult your allergist first. They can help you decide if a slower tapering process or a different form of treatment is appropriate for your situation.
If you miss a scheduled Wheat injection, contact your allergist's office immediately to reschedule. Do not attempt to make up for the missed dose by taking more later. If only a few days have passed, you may be able to receive your regular dose. However, if several weeks have passed, your immune system's sensitivity may have changed, and your doctor will likely need to reduce your next dose for safety before gradually building back up. Consistency is key to the success and safety of allergen immunotherapy.
There is no clinical evidence to suggest that Wheat allergenic extracts used in testing or immunotherapy cause weight gain. These extracts contain a very small amount of protein and have no caloric significance. However, if you are taking oral wheat germ supplements for their estrogenic properties, these are often rich in fats and calories, which could contribute to weight gain if not accounted for in your diet. Additionally, if you are prescribed oral corticosteroids to treat a severe reaction to wheat, those medications are well-known to cause temporary weight gain and fluid retention.
Wheat extracts can interact dangerously with certain medications, particularly those used for heart disease and high blood pressure. Beta-blockers are the most concerning, as they can prevent life-saving epinephrine from working if you have a severe allergic reaction. ACE inhibitors and certain antidepressants can also complicate the management of side effects. On the other hand, antihistamines can interfere with the accuracy of Wheat skin tests by masking the results. You must provide your healthcare provider with a complete list of all prescriptions, over-the-counter drugs, and herbal supplements you are using.
The concept of 'generic' vs 'brand name' is slightly different for allergenic extracts. Wheat extracts are biological products and are often referred to by their source name (e.g., 'Wheat Extract'). Different manufacturers, such as Greer Laboratories or HollisterStier, produce these extracts, and while they are similar, they are 'non-standardized,' meaning the potency can vary between brands. Therefore, they are not always interchangeable. Your allergist will typically stick with one manufacturer's product for the duration of your treatment to ensure the dosage remains consistent and safe.
> Warning: Stop taking Wheat and call your doctor immediately if you experience any of these.
With prolonged use of Wheat immunotherapy, the goal is to induce permanent changes in the immune system. However, long-term risks may include:
Wheat allergenic extracts carry a class-wide Black Box Warning for allergenic extracts:
Report any unusual symptoms to your healthcare provider.
While Wheat itself does not cause sedation, a systemic reaction or the administration of antihistamines to treat a local reaction can cause significant drowsiness. Use caution when driving after an appointment until you know how the treatment affects you.
Alcohol should be avoided on the day of a Wheat injection. Alcohol can increase blood flow to the skin and potentially speed up the absorption of the allergen, increasing the risk of a systemic reaction.
If Wheat immunotherapy is discontinued, the patient's sensitivity to wheat may eventually return to baseline levels. There is no 'withdrawal' syndrome, but the protective effect of the treatment will gradually fade. If you decide to stop, discuss a tapering or exit strategy with your allergist.
> Important: Discuss all your medical conditions with your healthcare provider before starting Wheat.
For each major interaction, the mechanism usually involves either the pharmacodynamic blocking of emergency rescue drugs (beta-blockers) or the immunological masking of symptoms (antihistamines). Management usually involves switching to alternative medications (e.g., replacing a beta-blocker with a calcium channel blocker) before starting Wheat therapy.
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking.
Conditions requiring a careful risk-benefit analysis include:
Patients allergic to Wheat may show cross-reactivity with other members of the Poaceae (grass) family, including:
> Important: Your healthcare provider will evaluate your complete medical history before prescribing Wheat.
Wheat extracts are used in children as young as 2 years old for diagnostic purposes. For immunotherapy, it is generally reserved for older children (5+ years) who can communicate symptoms of an impending reaction. Growth effects have not been observed with allergenic extracts. However, the emotional stress of frequent injections should be considered.
In patients over 65, Wheat extracts should be used with extreme caution.
In patients with chronic kidney disease (CKD), the skin may be less reactive (uremic pruritus or suppressed histamine response). While no dose adjustment is needed for the injection itself, the diagnostic accuracy of Wheat skin tests may be compromised.
No specific adjustments are required for allergenic extracts. For wheat-derived estrogenic supplements, patients with Child-Pugh Class B or C should use lower doses due to potentially reduced metabolism of phytoestrogenic compounds.
> Important: Special populations require individualized medical assessment.
| Parameter | Value |
|---|---|
| Bioavailability | High (Subcutaneous/Intradermal) |
| Protein Binding | 40-60% (Phytoestrogen components) |
| Half-life | 2-6 hours (Proteins); 12-24 hours (Metabolites) |
| Tmax | 30-60 minutes (Systemic absorption post-injection) |
| Metabolism | Proteolysis (Proteins); Hepatic Glucuronidation (Lignans) |
| Excretion | Renal (90%), Fecal (10%) |
Wheat is a Non-Standardized Food Allergenic Extract. It belongs to the broader class of Biological Response Modifiers and Allergenics. Related medications include extracts for Rye, Barley, and Oat.