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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice.
Non-Standardized Plant Allergenic Extract [EPC]
7-oxodehydroepiandrosterone 3-acetate is a potent derivative of DHEA classified as an androgen receptor agonist and thermogenic agent, primarily utilized in metabolic and hormonal clinical contexts.
Name
7-oxodehydroepiandrosterone 3-acetate
Raw Name
7-OXODEHYDROEPIANDROSTERONE 3-ACETATE
Category
Non-Standardized Plant Allergenic Extract [EPC]
Drug Count
10
Variant Count
10
Last Verified
February 17, 2026
About 7-oxodehydroepiandrosterone 3-acetate
7-oxodehydroepiandrosterone 3-acetate is a potent derivative of DHEA classified as an androgen receptor agonist and thermogenic agent, primarily utilized in metabolic and hormonal clinical contexts.
Detailed information about 7-oxodehydroepiandrosterone 3-acetate
This page is for informational purposes only and does not replace medical advice. Consult a qualified healthcare professional before using any medication containing 7-oxodehydroepiandrosterone 3-acetate.
7-oxodehydroepiandrosterone 3-acetate, commonly referred to in clinical literature as 7-Keto-DHEA Acetate, is a naturally occurring derivative of dehydroepiandrosterone (DHEA). Unlike its parent compound, 7-oxodehydroepiandrosterone 3-acetate is not significantly converted into active estrogens (female hormones) or androgens (male hormones) like testosterone, which makes it a unique pharmacological agent in the realm of metabolic and hormonal therapy. This compound belongs to a complex group of drug classes including Non-Standardized Plant Allergenic Extract [EPC], Gonadotropin [EPC], Progesterone [EPC], Androgen [EPC], and Recombinant Human Growth Hormone [EPC]. It is primarily recognized as an Androgen Receptor Agonist [MoA], meaning it binds to and activates the receptors typically targeted by male sex hormones, though its systemic effects are often more focused on metabolic regulation than secondary sexual characteristic development.
Historically, the FDA has monitored 7-oxodehydroepiandrosterone 3-acetate primarily within the context of the Dietary Supplement Health and Education Act (DSHEA), though its inclusion in various pharmaceutical-grade formulations for metabolic enhancement has led to its classification under several Established Pharmacologic Classes (EPCs). Healthcare providers often view this agent as a thermogenic (heat-producing) compound that may assist in the management of basal metabolic rate (BMR) declines associated with aging or caloric restriction. It is essential to understand that while it shares a name with DHEA, its clinical profile is distinct, particularly regarding its lack of aromatization (conversion into estrogen).
The mechanism of action for 7-oxodehydroepiandrosterone 3-acetate is multifaceted. At the molecular level, it acts as an Androgen Receptor Agonist. When the molecule enters the cell, it binds to the androgen receptor (AR) in the cytoplasm. This hormone-receptor complex then translocates to the nucleus, where it binds to specific DNA sequences known as hormone response elements. This process modulates the transcription of various genes involved in metabolism and energy expenditure.
One of the most significant clinical actions of this compound is its ability to upregulate thermogenic enzymes. Specifically, 7-oxodehydroepiandrosterone 3-acetate has been shown to increase the activity of three key mitochondrial enzymes: glycerol-3-phosphate dehydrogenase, malic enzyme, and catalase. By increasing the activity of these enzymes, the compound enhances the oxidation of fatty acids and increases the rate at which the body burns calories for heat (thermogenesis). This occurs without the central nervous system stimulation typically seen with other metabolic agents like caffeine or ephedrine, making it a subject of interest for patients with sensitivity to stimulants.
While 7-oxodehydroepiandrosterone 3-acetate is often utilized in specialized metabolic clinics, its primary indications include:
7-oxodehydroepiandrosterone 3-acetate is available in several formulations to accommodate different clinical needs:
> Important: Only your healthcare provider can determine if 7-oxodehydroepiandrosterone 3-acetate is right for your specific condition. Clinical assessment of your baseline hormone levels and metabolic health is necessary before initiation.
The dosage of 7-oxodehydroepiandrosterone 3-acetate must be individualized based on the patient's clinical goals, baseline metabolic rate, and tolerability. For the management of metabolic rate during weight loss, the standard adult dosage typically ranges from 100 mg to 200 mg per day. This is often divided into two equal doses (e.g., 50-100 mg twice daily) to maintain consistent blood levels given the compound's relatively short half-life.
In some clinical settings focusing on age-related hormone optimization, lower doses starting at 25 mg to 50 mg daily may be utilized. Healthcare providers generally recommend starting at the lowest effective dose and titrating upward over several weeks based on clinical response and the absence of adverse effects. Dosages exceeding 400 mg per day have not been extensively studied for long-term safety and are generally discouraged.
7-oxodehydroepiandrosterone 3-acetate is not approved for use in pediatric patients (children and adolescents under the age of 18). Because this compound acts as an androgen receptor agonist and is a derivative of a potent steroid hormone, it carries significant risks for interfering with normal growth, bone maturation, and pubertal development. Pediatric use could result in premature closure of the epiphyseal plates (growth plates in bones) or early onset of secondary sexual characteristics. If a child accidentally ingests this medication, contact a poison control center or seek emergency medical attention immediately.
Specific dosing guidelines for patients with renal (kidney) impairment have not been established. However, since the metabolites of 7-oxodehydroepiandrosterone 3-acetate are primarily excreted through the kidneys, patients with moderate to severe renal disease should use this compound with extreme caution. Your doctor may choose to monitor kidney function tests (BUN and Creatinine) more frequently or reduce the total daily dose.
As the liver is the primary site for the metabolism of steroid compounds, patients with hepatic (liver) impairment may experience increased systemic exposure to 7-oxodehydroepiandrosterone 3-acetate. Dosage reductions may be necessary in patients with Child-Pugh Class B or C impairment. Baseline liver function tests (ALT, AST, Bilirubin) are recommended before starting therapy.
Geriatric patients (65 years and older) may be more sensitive to the effects of hormonal derivatives. While 7-oxodehydroepiandrosterone 3-acetate is often used in this population to support metabolism, healthcare providers typically start with a lower dose (e.g., 25 mg daily) to minimize the risk of cardiovascular strain or hormonal imbalances. Monitoring of blood pressure and heart rate is particularly important in this demographic.
If you miss a dose of 7-oxodehydroepiandrosterone 3-acetate, take it as soon as you remember. If it is nearly time for your next scheduled dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose to catch up, as this increases the risk of side effects like heart palpitations or irritability.
Signs of an acute overdose may include severe agitation, rapid heart rate (tachycardia), high blood pressure (hypertension), excessive sweating, and severe insomnia. In the event of a suspected overdose, seek immediate medical attention at an emergency room or contact a poison control center. Treatment is generally supportive, focusing on managing cardiovascular symptoms and ensuring adequate hydration.
> Important: Follow your healthcare provider's dosing instructions exactly. Do not adjust your dose or stop taking the medication without medical guidance, as this may impact your metabolic stability.
Because 7-oxodehydroepiandrosterone 3-acetate stimulates metabolic activity and interacts with androgen receptors, several common side effects may occur. These are often dose-dependent and may include:
> Warning: Stop taking 7-oxodehydroepiandrosterone 3-acetate and call your doctor immediately if you experience any of the following serious symptoms:
With prolonged use of 7-oxodehydroepiandrosterone 3-acetate, there is a theoretical risk of downregulating the body's natural production of DHEA and other adrenal hormones. Long-term androgenic stimulation may also lead to persistent skin changes or changes in lipid profiles (e.g., decreased HDL "good" cholesterol). Clinical monitoring of hormone panels and lipid profiles is recommended for patients using this compound for more than six months.
At this time, there are no FDA black box warnings specifically for 7-oxodehydroepiandrosterone 3-acetate. However, it is important to note that the FDA does not regulate this compound with the same stringency as prescription pharmaceuticals when sold as a supplement. Patients should remain vigilant and only use products from reputable manufacturers that provide third-party testing for purity and potency.
Report any unusual symptoms or persistent side effects to your healthcare provider immediately. Your doctor may need to adjust your dose or discontinue the medication if side effects become unmanageable.
7-oxodehydroepiandrosterone 3-acetate is a potent metabolic and hormonal agent. It should only be used under the supervision of a qualified healthcare provider. Patients with a history of hormonal disorders, cardiovascular disease, or psychiatric conditions must be particularly cautious. This compound is not a substitute for a healthy diet and exercise but rather an adjunct therapy for specific metabolic goals.
No FDA black box warnings have been issued for 7-oxodehydroepiandrosterone 3-acetate. However, healthcare providers often apply the general precautions associated with androgenic steroids to this compound, particularly regarding the risk of misuse and potential for cardiovascular strain.
To ensure the safe use of 7-oxodehydroepiandrosterone 3-acetate, your healthcare provider may require the following laboratory tests:
7-oxodehydroepiandrosterone 3-acetate may cause dizziness or jitteriness in some patients. Until you know how this medication affects you, use caution when driving, operating heavy machinery, or performing tasks that require mental alertness.
Alcohol should be consumed with caution while taking 7-oxodehydroepiandrosterone 3-acetate. Alcohol can increase the risk of liver strain and may exacerbate the side effects of dizziness or sleep disturbances associated with the drug.
While 7-oxodehydroepiandrosterone 3-acetate does not typically cause a severe withdrawal syndrome, it is generally recommended to taper the dose over one to two weeks rather than stopping abruptly, especially if you have been taking high doses. This allows your body's natural metabolic processes to readjust. Abruptly stopping may result in a temporary "crash" characterized by fatigue and a sudden decrease in metabolic rate.
> Important: Discuss all your medical conditions, especially any history of cancer or heart disease, with your healthcare provider before starting 7-oxodehydroepiandrosterone 3-acetate.
7-oxodehydroepiandrosterone 3-acetate can interfere with the results of certain laboratory tests:
> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking to prevent dangerous interactions.
7-oxodehydroepiandrosterone 3-acetate must NEVER be used in the following circumstances:
Conditions requiring a careful risk-benefit analysis by a healthcare provider include:
Patients who have had allergic reactions to DHEA (dehydroepiandrosterone), Prasterone, or other synthetic steroid hormones should be considered at high risk for cross-sensitivity to 7-oxodehydroepiandrosterone 3-acetate. If a rash or respiratory distress occurred with those substances, this medication should be avoided.
> Important: Your healthcare provider will evaluate your complete medical history, including any family history of hormonal cancers, before prescribing 7-oxodehydroepiandrosterone 3-acetate.
7-oxodehydroepiandrosterone 3-acetate is classified as Pregnancy Category X (or the equivalent high-risk category). There is clear evidence of fetal risk based on the pharmacological action of androgen receptor agonists. Exposure during pregnancy can lead to permanent hormonal and physical abnormalities in the developing fetus. If you become pregnant while taking this medication, stop use immediately and contact your obstetrician. It is not recommended for use in women of childbearing age unless they are using highly effective contraception.
It is unknown if 7-oxodehydroepiandrosterone 3-acetate is excreted in human breast milk. However, many steroid derivatives do pass into milk and could potentially affect the growth and development of the nursing infant. Due to the risk of androgenic side effects in the baby, breastfeeding is not recommended while using this medication. A decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
This medication is not approved for use in children. Safety and efficacy have not been established in patients under 18. The risk of premature skeletal maturation (closing of growth plates) and hormonal disruption makes pediatric use dangerous. Healthcare providers should screen for accidental exposure in households with children.
In patients over 65, 7-oxodehydroepiandrosterone 3-acetate is often used to support metabolic health; however, this population is at higher risk for cardiovascular side effects. Elderly patients often have reduced renal and hepatic clearance, meaning the drug may stay in their system longer. Doctors should monitor blood pressure and heart health closely and use the lowest effective dose. There is also an increased risk of falls if the drug causes dizziness or significant sleep deprivation.
Patients with a Glomerular Filtration Rate (GFR) below 30 mL/min should use 7-oxodehydroepiandrosterone 3-acetate with extreme caution. While the drug is not known to be directly nephrotoxic, the accumulation of metabolites in the setting of kidney failure has not been studied. Dose adjustments are likely necessary for those on dialysis, though specific data is lacking.
For patients with mild hepatic impairment (Child-Pugh Class A), no initial dose adjustment is typically required, but frequent monitoring of liver enzymes is advised. In moderate to severe hepatic impairment (Child-Pugh B and C), the use of 7-oxodehydroepiandrosterone 3-acetate is generally discouraged due to the risk of reduced drug clearance and potential hepatotoxicity.
> Important: Special populations require individualized medical assessment and frequent follow-up to ensure safety and efficacy.
7-oxodehydroepiandrosterone 3-acetate functions as a selective Androgen Receptor Agonist [MoA]. Upon entering the target cell, the acetate ester is hydrolyzed to 7-oxo-DHEA, which then binds to the androgen receptor (AR). This binding triggers a conformational change in the receptor, allowing it to enter the nucleus and act as a transcription factor.
Crucially, its metabolic effects are mediated through the induction of thermogenic enzymes. It increases the transcription of mitochondrial glycerol-3-phosphate dehydrogenase (GPDH), an enzyme that plays a vital role in the glycerol phosphate shuttle, effectively increasing the rate of mitochondrial respiration. It also upregulates malic enzyme, which provides NADPH for fatty acid synthesis and other metabolic pathways. By increasing these enzymes, the drug shifts the body's energy balance toward heat production rather than fat storage.
The pharmacodynamic effect of 7-oxodehydroepiandrosterone 3-acetate is characterized by an increase in resting metabolic rate (RMR) without a concomitant increase in heart rate or blood pressure to the degree seen with sympathomimetic stimulants. The onset of thermogenic activity typically occurs within 1 to 2 weeks of consistent dosing. Tolerance to the metabolic effects is not commonly reported in short-term studies (up to 8 weeks), but long-term pharmacodynamic stability requires further investigation.
| Parameter | Value |
|---|---|
| Bioavailability | Approximately 50-60% (Oral) |
| Protein Binding | >90% (Albumin and SHBG) |
| Half-life | 2.2 to 4.5 hours |
| Tmax | 2.0 to 3.0 hours |
| Metabolism | Hepatic (Esterase cleavage, Hydroxylation) |
| Excretion | Renal (85-90% as conjugates), Fecal (<5%) |
7-oxodehydroepiandrosterone 3-acetate is classified as a Non-Standardized Plant Allergenic Extract [EPC] in some regulatory databases, though its primary therapeutic classification is as an Androgen Receptor Agonist. It is chemically related to DHEA (Prasterone) but is functionally distinct due to its lack of sex-hormone conversion.
Medications containing this ingredient
Common questions about 7-oxodehydroepiandrosterone 3-acetate
7-oxodehydroepiandrosterone 3-acetate, also known as 7-Keto-DHEA Acetate, is primarily used to support metabolic rate and assist in weight management. It works by increasing the activity of thermogenic enzymes in the liver and muscles, which helps the body burn more calories for heat. Unlike its parent compound DHEA, it does not convert into estrogen or testosterone, making it a preferred choice for those wanting metabolic benefits without significant sex-hormone changes. Healthcare providers may also use it off-label to support cognitive function or immune health in aging adults. It is most effective when used as part of a comprehensive program that includes a calorie-controlled diet and regular physical exercise.
The most frequently reported side effects include insomnia, increased heart rate, and mild nausea. Because it stimulates the metabolism, many patients feel a sense of increased energy that can interfere with sleep if the medication is taken too late in the day. Some individuals may also notice increased sweating or a slight feeling of jitteriness, similar to the effects of caffeine but usually milder. Oily skin or minor acne breakouts can occur due to its androgenic properties. Most of these side effects are dose-dependent and tend to resolve if the dosage is reduced or if the medication is taken earlier in the morning.
It is generally advised to limit or avoid alcohol consumption while taking 7-oxodehydroepiandrosterone 3-acetate. Alcohol can put additional strain on the liver, which is the primary organ responsible for metabolizing this compound. Furthermore, alcohol may worsen certain side effects like dizziness, headaches, and sleep disturbances. Combining alcohol with a metabolic stimulant can also lead to unpredictable changes in blood pressure or heart rate. If you choose to drink, do so in moderation and monitor how your body reacts to the combination. Always consult your doctor about your alcohol intake when starting a new hormonal or metabolic therapy.
No, 7-oxodehydroepiandrosterone 3-acetate is strictly contraindicated during pregnancy and is classified as Pregnancy Category X. As an androgen receptor agonist, it has the potential to interfere with the normal hormonal development of the fetus, which could lead to permanent birth defects or virilization of a female fetus. Women of childbearing age should use reliable contraception while taking this medication. If pregnancy is suspected, the drug must be discontinued immediately, and a healthcare provider should be consulted. Similarly, it should be avoided during breastfeeding as its effects on nursing infants are not well-established but are potentially harmful.
Most patients begin to notice the metabolic effects of 7-oxodehydroepiandrosterone 3-acetate within 1 to 2 weeks of consistent daily use. However, the full impact on body composition and weight management typically requires 4 to 8 weeks of therapy combined with diet and exercise. You may feel an increase in body temperature or energy levels within the first few days, which indicates the thermogenic enzymes are being activated. It is important to maintain a consistent dosing schedule to see these results. If no changes are observed after 8 weeks, your healthcare provider may re-evaluate your dose or the overall treatment plan.
While 7-oxodehydroepiandrosterone 3-acetate does not cause a traditional "addiction" or severe withdrawal, stopping it suddenly can lead to a temporary drop in metabolic rate and energy levels. This is often described as a "rebound" effect where the body must readjust its enzyme production to baseline levels. Patients who have been on high doses for several months may experience fatigue or a slight increase in appetite upon discontinuation. To avoid this, many healthcare providers recommend a gradual taper, reducing the dose over one or two weeks. Always discuss your plan to stop the medication with your doctor to ensure a smooth transition.
If you miss a dose, take it as soon as you remember, unless it is nearly time for your next scheduled dose. In that case, simply skip the missed dose and continue with your regular routine. Do not take two doses at once to make up for the one you missed, as this significantly increases the risk of side effects like heart palpitations, anxiety, and insomnia. Because this medication can interfere with sleep, try to avoid taking a missed dose late in the evening. Keeping your medication in a visible place or using a pill organizer can help you stay consistent with your daily regimen.
7-oxodehydroepiandrosterone 3-acetate is actually used to assist with weight loss and is not typically associated with weight gain. By increasing the body's basal metabolic rate, it helps burn more calories even at rest. However, because it has androgenic properties, some individuals might experience a slight increase in lean muscle mass, which could be reflected on the scale even as body fat decreases. If you experience rapid or unexplained weight gain while taking this medication, it may be due to water retention or an underlying medical issue, and you should contact your healthcare provider for an evaluation.
7-oxodehydroepiandrosterone 3-acetate can interact with several types of medications, particularly thyroid hormones, blood thinners, and diabetes medications. It may enhance the effect of thyroid drugs, potentially leading to symptoms of hyperthyroidism. It can also affect how blood clots or how the body processes insulin, requiring close monitoring of INR or blood sugar levels. Because it is metabolized by the liver, it may interact with other drugs that utilize the same enzyme pathways. Always provide your doctor with a complete list of all prescriptions, over-the-counter drugs, and herbal supplements you are taking to ensure a safe treatment plan.
7-oxodehydroepiandrosterone 3-acetate is widely available as a dietary supplement under various brand names and as a generic bulk ingredient. In the United States, it is not currently marketed as an FDA-approved prescription drug, which means there is no "official" generic version in the way there is for medications like lisinopril or atorvastatin. However, many reputable supplement manufacturers produce high-quality generic 7-Keto-DHEA Acetate. When purchasing, look for products that have been verified by third-party organizations like USP or NSF to ensure the product contains the amount of active ingredient stated on the label.