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The dosage of 7-oxodehydroepiandrosterone 3-acetate must be individualized based on the patient's clinical goals, baseline metabolic rate, and tolerability. For the management of metabolic rate during weight loss, the standard adult dosage typically ranges from 100 mg to 200 mg per day. This is often divided into two equal doses (e.g., 50-100 mg twice daily) to maintain consistent blood levels given the compound's relatively short half-life.

In some clinical settings focusing on age-related hormone optimization, lower doses starting at 25 mg to 50 mg daily may be utilized. Healthcare providers generally recommend starting at the lowest effective dose and titrating upward over several weeks based on clinical response and the absence of adverse effects. Dosages exceeding 400 mg per day have not been extensively studied for long-term safety and are generally discouraged.

7-oxodehydroepiandrosterone 3-acetate is not approved for use in pediatric patients (children and adolescents under the age of 18). Because this compound acts as an androgen receptor agonist and is a derivative of a potent steroid hormone, it carries significant risks for interfering with normal growth, bone maturation, and pubertal development. Pediatric use could result in premature closure of the epiphyseal plates (growth plates in bones) or early onset of secondary sexual characteristics. If a child accidentally ingests this medication, contact a poison control center or seek emergency medical attention immediately.

Renal Impairment

Specific dosing guidelines for patients with renal (kidney) impairment have not been established. However, since the metabolites of 7-oxodehydroepiandrosterone 3-acetate are primarily excreted through the kidneys, patients with moderate to severe renal disease should use this compound with extreme caution. Your doctor may choose to monitor kidney function tests (BUN and Creatinine) more frequently or reduce the total daily dose.

Hepatic Impairment

As the liver is the primary site for the metabolism of steroid compounds, patients with hepatic (liver) impairment may experience increased systemic exposure to 7-oxodehydroepiandrosterone 3-acetate. Dosage reductions may be necessary in patients with Child-Pugh Class B or C impairment. Baseline liver function tests (ALT, AST, Bilirubin) are recommended before starting therapy.

Elderly Patients

Geriatric patients (65 years and older) may be more sensitive to the effects of hormonal derivatives. While 7-oxodehydroepiandrosterone 3-acetate is often used in this population to support metabolism, healthcare providers typically start with a lower dose (e.g., 25 mg daily) to minimize the risk of cardiovascular strain or hormonal imbalances. Monitoring of blood pressure and heart rate is particularly important in this demographic.

• Administration: Take the capsule or tablet with a full glass of water. It can be taken with or without food, but taking it with a small meal containing some fat may improve absorption.
• Timing: For best results, doses are usually taken in the morning and early afternoon. Avoid taking this medication late in the evening, as its thermogenic (metabolic-stimulating) effects may interfere with sleep (insomnia).
• Consistency: Take the medication at the same time each day to maintain steady plasma concentrations.
• Storage: Store at room temperature (68°F to 77°F or 20°C to 25°C) away from moisture, heat, and direct sunlight. Keep the container tightly closed when not in use.

If you miss a dose of 7-oxodehydroepiandrosterone 3-acetate, take it as soon as you remember. If it is nearly time for your next scheduled dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose to catch up, as this increases the risk of side effects like heart palpitations or irritability.

Signs of an acute overdose may include severe agitation, rapid heart rate (tachycardia), high blood pressure (hypertension), excessive sweating, and severe insomnia. In the event of a suspected overdose, seek immediate medical attention at an emergency room or contact a poison control center. Treatment is generally supportive, focusing on managing cardiovascular symptoms and ensuring adequate hydration.

> Important: Follow your healthcare provider's dosing instructions exactly. Do not adjust your dose or stop taking the medication without medical guidance, as this may impact your metabolic stability.

Because 7-oxodehydroepiandrosterone 3-acetate stimulates metabolic activity and interacts with androgen receptors, several common side effects may occur. These are often dose-dependent and may include:

• Insomnia: Difficulty falling or staying asleep is the most frequently reported side effect, especially if the dose is taken late in the day. This typically feels like a "wired" sensation or restlessness.
• Increased Heart Rate: Patients may notice a slight increase in their resting pulse. While usually mild, it can feel like a fluttering in the chest.
• Mild Nausea: Some individuals experience stomach upset shortly after taking the medication, which can often be mitigated by taking the dose with food.
• Increased Perspiration: Due to the thermogenic nature of the drug, patients may feel warmer than usual and sweat more easily during physical activity.

• Irritability or Mood Swings: Some patients report feeling more "on edge" or easily frustrated, likely due to the androgenic activity of the compound.
• Oily Skin and Acne: Increased sebum production can lead to breakouts on the face, back, or chest.
• Headaches: Tension-type headaches may occur as the body adjusts to the metabolic changes.
• Dizziness: A feeling of lightheadedness, particularly when standing up quickly, has been reported in a small percentage of users.

• Hair Thinning: In genetically predisposed individuals, androgen receptor agonists may contribute to male or female pattern baldness (androgenetic alopecia).
• Changes in Menstrual Cycle: Women may experience spotting or changes in the timing of their periods due to the hormonal influence of the compound.
• Elevated Liver Enzymes: Rare cases of mild elevations in ALT or AST have been noted, requiring monitoring by a physician.
• Palpitations: Strong or irregular heartbeats that may require a reduction in dosage.

> Warning: Stop taking 7-oxodehydroepiandrosterone 3-acetate and call your doctor immediately if you experience any of the following serious symptoms:

• Chest Pain or Pressure: This could indicate cardiovascular strain or an underlying heart issue exacerbated by increased metabolic rate.
• Severe Hypertension: Symptoms include a pounding headache, blurred vision, or confusion.
• Signs of an Allergic Reaction: Hives, difficulty breathing, or swelling of the face, lips, tongue, or throat (anaphylaxis).
• Jaundice: Yellowing of the skin or the whites of the eyes, which may indicate liver toxicity.
• Shortness of Breath: Difficulty breathing even at rest or with minimal exertion.
• Prostate Changes: Men should report any difficulty urinating or increased frequency of urination, as androgenic compounds can affect prostate tissue.

With prolonged use of 7-oxodehydroepiandrosterone 3-acetate, there is a theoretical risk of downregulating the body's natural production of DHEA and other adrenal hormones. Long-term androgenic stimulation may also lead to persistent skin changes or changes in lipid profiles (e.g., decreased HDL "good" cholesterol). Clinical monitoring of hormone panels and lipid profiles is recommended for patients using this compound for more than six months.

At this time, there are no FDA black box warnings specifically for 7-oxodehydroepiandrosterone 3-acetate. However, it is important to note that the FDA does not regulate this compound with the same stringency as prescription pharmaceuticals when sold as a supplement. Patients should remain vigilant and only use products from reputable manufacturers that provide third-party testing for purity and potency.

Report any unusual symptoms or persistent side effects to your healthcare provider immediately. Your doctor may need to adjust your dose or discontinue the medication if side effects become unmanageable.

7-oxodehydroepiandrosterone 3-acetate is a potent metabolic and hormonal agent. It should only be used under the supervision of a qualified healthcare provider. Patients with a history of hormonal disorders, cardiovascular disease, or psychiatric conditions must be particularly cautious. This compound is not a substitute for a healthy diet and exercise but rather an adjunct therapy for specific metabolic goals.

No FDA black box warnings have been issued for 7-oxodehydroepiandrosterone 3-acetate. However, healthcare providers often apply the general precautions associated with androgenic steroids to this compound, particularly regarding the risk of misuse and potential for cardiovascular strain.

• Allergic Reactions / Anaphylaxis Risk: While rare, hypersensitivity to 7-oxodehydroepiandrosterone 3-acetate or any of the inactive ingredients (such as cellulose or gelatin in the capsule) can occur. Seek emergency care if you develop a rash, severe itching, or swelling.
• Hormone-Sensitive Conditions: Because this drug is an androgen receptor agonist, it should be avoided in patients with hormone-sensitive cancers, such as prostate, breast, or ovarian cancer. There is a risk that the compound could stimulate the growth of these malignant cells.
• Cardiovascular Health: This agent can increase heart rate and blood pressure. It should be used with extreme caution in patients with a history of arrhythmias, heart failure, or recent myocardial infarction (heart attack).
• Thyroid Function: 7-oxodehydroepiandrosterone 3-acetate may interact with thyroid hormone pathways. Patients with hyperthyroidism or hypothyroidism should have their thyroid levels (TSH, T3, T4) monitored closely.
• Psychiatric Effects: Androgenic compounds can sometimes exacerbate symptoms of anxiety, mania, or aggression. Patients with bipolar disorder or severe anxiety should use this agent only under close psychiatric supervision.

To ensure the safe use of 7-oxodehydroepiandrosterone 3-acetate, your healthcare provider may require the following laboratory tests:

• Liver Function Tests (LFTs): To check for potential hepatotoxicity.
• Lipid Panel: To monitor changes in cholesterol and triglyceride levels.
• Hormone Panel: Including DHEA-S, Testosterone (Free and Total), and Estradiol to ensure systemic hormonal balance is maintained.
• Blood Pressure and Heart Rate: Regular monitoring at each clinical visit.

7-oxodehydroepiandrosterone 3-acetate may cause dizziness or jitteriness in some patients. Until you know how this medication affects you, use caution when driving, operating heavy machinery, or performing tasks that require mental alertness.

Alcohol should be consumed with caution while taking 7-oxodehydroepiandrosterone 3-acetate. Alcohol can increase the risk of liver strain and may exacerbate the side effects of dizziness or sleep disturbances associated with the drug.

While 7-oxodehydroepiandrosterone 3-acetate does not typically cause a severe withdrawal syndrome, it is generally recommended to taper the dose over one to two weeks rather than stopping abruptly, especially if you have been taking high doses. This allows your body's natural metabolic processes to readjust. Abruptly stopping may result in a temporary "crash" characterized by fatigue and a sudden decrease in metabolic rate.

> Important: Discuss all your medical conditions, especially any history of cancer or heart disease, with your healthcare provider before starting 7-oxodehydroepiandrosterone 3-acetate.

• Anabolic Steroids: Using 7-oxodehydroepiandrosterone 3-acetate with other anabolic steroids or androgenic agents significantly increases the risk of severe hormonal imbalances, liver damage, and cardiovascular complications. This combination can lead to excessive androgenic effects like virilization in women and prostate enlargement in men.
• Aromatase Inhibitors (e.g., Anastrozole, Letrozole): While 7-Keto-DHEA does not aromatize, combining it with drugs that block estrogen production can lead to dangerously low estrogen levels, affecting bone density and cardiovascular health.

• Thyroid Medications (e.g., Levothyroxine): 7-oxodehydroepiandrosterone 3-acetate can enhance the effects of thyroid hormones. This may lead to symptoms of hyperthyroidism, such as rapid heart rate, tremors, and anxiety. Your doctor may need to adjust your thyroid medication dose.
• Anticoagulants and Antiplatelets (e.g., Warfarin, Clopidogrel): There is some evidence that steroid derivatives can influence blood clotting factors. Using these together may increase the risk of bruising or bleeding. Regular monitoring of the International Normalized Ratio (INR) is essential for patients on Warfarin.
• Insulin and Oral Antidiabetics: Because this compound affects metabolism and may improve insulin sensitivity, it could potentially lower blood glucose levels. Patients with diabetes should monitor their blood sugar closely to avoid hypoglycemia (low blood sugar).

• CYP3A4 Inducers/Inhibitors: Although the specific CYP pathways for 7-oxodehydroepiandrosterone 3-acetate are not fully mapped, most steroid hormones are metabolized by the CYP3A4 enzyme. Drugs like ketoconazole (inhibitor) or rifampin (inducer) may alter the blood levels of this compound.
• Corticosteroids: Long-term use of prednisone or other steroids may have additive effects on metabolism and immune function when combined with this agent.

• High-Fat Meals: As noted, dietary fat can increase the absorption of 7-oxodehydroepiandrosterone 3-acetate. While not a negative interaction, it is best to be consistent with your meal habits when taking the medication to ensure predictable blood levels.
• Caffeine and Stimulants: Combining this thermogenic agent with high amounts of caffeine, green tea extract, or other stimulants can lead to excessive heart rate, jitteriness, and severe insomnia.

• St. John's Wort: This herb is a potent inducer of liver enzymes and may reduce the effectiveness of 7-oxodehydroepiandrosterone 3-acetate by speeding up its clearance from the body.
• DHEA Supplements: Taking 7-Keto-DHEA Acetate alongside standard DHEA is generally redundant and increases the risk of side effects, as both compounds compete for similar metabolic pathways.
• Tribulus Terrestris / Fenugreek: These supplements, often used for hormonal support, may have additive androgenic effects.

7-oxodehydroepiandrosterone 3-acetate can interfere with the results of certain laboratory tests:

• Urine Steroid Profiles: It may cause false positives or abnormal readings in athletic drug testing screens for prohibited substances.
• Blood Hormone Tests: It may slightly alter the readings for DHEA-S and other adrenal markers.

> Important: Tell your doctor about ALL medications, supplements, and herbal products you are taking to prevent dangerous interactions.

7-oxodehydroepiandrosterone 3-acetate must NEVER be used in the following circumstances:

• Pregnancy and Breastfeeding: Due to its androgenic activity, this compound is strictly contraindicated. It can cause developmental harm to the fetus or infant, including the potential for virilization (development of male characteristics in a female fetus).
• Hormone-Sensitive Cancers: Patients with active or a history of prostate cancer, breast cancer, uterine cancer, or ovarian cancer must not use this drug. The androgen receptor agonist activity may promote the growth and spread of these tumors.
• Severe Hepatic Failure: Patients with end-stage liver disease cannot adequately metabolize this compound, leading to toxic accumulation.
• Hypersensitivity: Anyone with a known allergy to 7-oxodehydroepiandrosterone 3-acetate or related steroid derivatives should avoid its use.

Conditions requiring a careful risk-benefit analysis by a healthcare provider include:

• Benign Prostatic Hyperplasia (BPH): Men with an enlarged prostate may experience worsening of urinary symptoms (e.g., weak stream, frequent nighttime urination) due to androgenic stimulation.
• Active Heart Disease: Those with unstable angina, recent stroke, or severe arrhythmias should only use this compound if the metabolic benefits clearly outweigh the cardiovascular risks.
• Severe Anxiety or Mania: Patients with a history of psychiatric instability may find that the stimulating effects of the drug exacerbate their condition.
• Endometriosis or Uterine Fibroids: These conditions can be sensitive to fluctuations in the hormonal environment, and 7-oxodehydroepiandrosterone 3-acetate may cause symptom flare-ups.

Patients who have had allergic reactions to DHEA (dehydroepiandrosterone), Prasterone, or other synthetic steroid hormones should be considered at high risk for cross-sensitivity to 7-oxodehydroepiandrosterone 3-acetate. If a rash or respiratory distress occurred with those substances, this medication should be avoided.

> Important: Your healthcare provider will evaluate your complete medical history, including any family history of hormonal cancers, before prescribing 7-oxodehydroepiandrosterone 3-acetate.

7-oxodehydroepiandrosterone 3-acetate is classified as Pregnancy Category X (or the equivalent high-risk category). There is clear evidence of fetal risk based on the pharmacological action of androgen receptor agonists. Exposure during pregnancy can lead to permanent hormonal and physical abnormalities in the developing fetus. If you become pregnant while taking this medication, stop use immediately and contact your obstetrician. It is not recommended for use in women of childbearing age unless they are using highly effective contraception.

It is unknown if 7-oxodehydroepiandrosterone 3-acetate is excreted in human breast milk. However, many steroid derivatives do pass into milk and could potentially affect the growth and development of the nursing infant. Due to the risk of androgenic side effects in the baby, breastfeeding is not recommended while using this medication. A decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

This medication is not approved for use in children. Safety and efficacy have not been established in patients under 18. The risk of premature skeletal maturation (closing of growth plates) and hormonal disruption makes pediatric use dangerous. Healthcare providers should screen for accidental exposure in households with children.

In patients over 65, 7-oxodehydroepiandrosterone 3-acetate is often used to support metabolic health; however, this population is at higher risk for cardiovascular side effects. Elderly patients often have reduced renal and hepatic clearance, meaning the drug may stay in their system longer. Doctors should monitor blood pressure and heart health closely and use the lowest effective dose. There is also an increased risk of falls if the drug causes dizziness or significant sleep deprivation.

Patients with a Glomerular Filtration Rate (GFR) below 30 mL/min should use 7-oxodehydroepiandrosterone 3-acetate with extreme caution. While the drug is not known to be directly nephrotoxic, the accumulation of metabolites in the setting of kidney failure has not been studied. Dose adjustments are likely necessary for those on dialysis, though specific data is lacking.

For patients with mild hepatic impairment (Child-Pugh Class A), no initial dose adjustment is typically required, but frequent monitoring of liver enzymes is advised. In moderate to severe hepatic impairment (Child-Pugh B and C), the use of 7-oxodehydroepiandrosterone 3-acetate is generally discouraged due to the risk of reduced drug clearance and potential hepatotoxicity.

> Important: Special populations require individualized medical assessment and frequent follow-up to ensure safety and efficacy.

7-oxodehydroepiandrosterone 3-acetate functions as a selective Androgen Receptor Agonist [MoA]. Upon entering the target cell, the acetate ester is hydrolyzed to 7-oxo-DHEA, which then binds to the androgen receptor (AR). This binding triggers a conformational change in the receptor, allowing it to enter the nucleus and act as a transcription factor.

Crucially, its metabolic effects are mediated through the induction of thermogenic enzymes. It increases the transcription of mitochondrial glycerol-3-phosphate dehydrogenase (GPDH), an enzyme that plays a vital role in the glycerol phosphate shuttle, effectively increasing the rate of mitochondrial respiration. It also upregulates malic enzyme, which provides NADPH for fatty acid synthesis and other metabolic pathways. By increasing these enzymes, the drug shifts the body's energy balance toward heat production rather than fat storage.

The pharmacodynamic effect of 7-oxodehydroepiandrosterone 3-acetate is characterized by an increase in resting metabolic rate (RMR) without a concomitant increase in heart rate or blood pressure to the degree seen with sympathomimetic stimulants. The onset of thermogenic activity typically occurs within 1 to 2 weeks of consistent dosing. Tolerance to the metabolic effects is not commonly reported in short-term studies (up to 8 weeks), but long-term pharmacodynamic stability requires further investigation.

| Parameter | Value |

|---|---|

| Bioavailability | Approximately 50-60% (Oral) |

| Protein Binding | >90% (Albumin and SHBG) |

| Half-life | 2.2 to 4.5 hours |

| Tmax | 2.0 to 3.0 hours |

| Metabolism | Hepatic (Esterase cleavage, Hydroxylation) |

| Excretion | Renal (85-90% as conjugates), Fecal (<5%) |

• Molecular Formula: C21H28O4
• Molecular Weight: 344.4 g/mol
• Solubility: Lipophilic; poorly soluble in water, soluble in ethanol and organic solvents.
• Structure: A polycyclic steroid nucleus with a ketone group at the 7-position and an acetate ester at the 3-position. This modification at the 7-position prevents the molecule from being converted into testosterone or estradiol via the standard steroidogenic pathways.

7-oxodehydroepiandrosterone 3-acetate is classified as a Non-Standardized Plant Allergenic Extract [EPC] in some regulatory databases, though its primary therapeutic classification is as an Androgen Receptor Agonist. It is chemically related to DHEA (Prasterone) but is functionally distinct due to its lack of sex-hormone conversion.